Pharmaceutical Excipients: Impact on Efficiency, Stability, and Solubility in Formulation
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 111
Special Issue Editors
Interests: drug solubility; cyclodextrin-based delivery systems; drug analysis and quality control; drug stability; drug–drug interactions; drug-excipient interactions
Special Issues, Collections and Topics in MDPI journals
Interests: drug stability and stabilization techniques; instrumental analysis of active pharmaceutical ingredients; heterogenous degradation of drugs; solid-state kinetics; supramolecular systems with increased biopharmaceutical profile
Special Issues, Collections and Topics in MDPI journals
Interests: stability of drugs and compounds with potential biological activity; instrumental analysis of drugs as pure APIs and in pharmaceutical dosage forms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pharmaceutical excipients are substances, other than the active pharmaceutical ingredient (API), of invaluable importance for the final dosage forms. They facilitate the manufacture, stability, patient compliance, and administration of pharmaceutical formulations and also possess various functional roles that include modulating the solubility and bioavailability of APIs, delivering APIs, maintaining the osmolarity and pH of the liquid formulations, and preventing aggregation and dissociation. Nowadays, pharmaceutical excipients have gained the attention of researchers due to the growth of novel drug delivery systems that led to an increase in the number of the excipients, the development of new co-processed excipient mixtures, and also because of their potential to alter the pharmacokinetic profile of drugs. The quality, efficiency, safety, and stability of the finished pharmaceutical formulations highly depend on the choice of excipients, their concentration, and their interaction with APIs and with each other.
This Special Issue aims to collect research dedicated to all aspects of the excipients in pharmaceutical and cosmetic formulations. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: drug–excipient compatibility studies; the effect of excipients on metabolic enzymes; the solubility of natural and synthetic active substances; drug release; and issues related to drug stability.
We look forward to receiving your contributions.
Prof. Dr. Laura Sbârcea
Prof. Dr. Adriana Violeta Ledeți
Dr. Denisa Laura Ivan
Guest Editors
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Keywords
- excipient
- drug-excipient interaction
- drug solubility
- cyclodextrins
- solid-state kinetics
- drug delivery systems
- drug release
- bioavailability
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