Electrospun Fibers, Tissue Engineering, and Drug Delivery: Strategies and Potential Solutions for a Complex Issue

Dear Colleagues,

Electrospinning, a well-known versatile technique which can be utilised to fabricate nanofibers effective in mimicking the extracellular matrix, promotes cellular adhesion, proliferation, and differentiation. Furthermore, perhaps the second most important properties of these fibres are their huge surface-to-volume ratio and their potential for drug delivery and controlled drug release. However, tissue integration of medical implants is a challenging and complex issue due to several factors: from achieving biocompatibility to tuning biodegradability and finally functionalizing an implant, the task is far from simple.

Achieving a stable interface between the implant and the surrounding tissue requires promoting cellular adhesion and growth, while preventing the formation of a fibrous capsule that isolates the implant is quite a challenge.

Another layer of complexity starts when one considers infection, chronic inflammation, and implant rejection.

The current Special Issue explores how electrospun fibres can be engineered to incorporate various bioactive molecules, facilitating localized and sustained drug delivery to promote wound healing or inhibit wound infection. This Special Issue aims to provide a platform for the publication of innovative approaches, including alternative electrospinning setups, pre- and post-processing techniques, and drug incorporation strategies, as well as any other innovative approaches focusing on the tissue integration of advanced systems. In addition, this Special Issue also aims to focus on the use of multiple natural or synthetic polymers, inorganic components, and composites emphasizing synergistic effects.

Best regards,

Dr. Adrienn Kazsoki
Dr. Constantinos Voniatis
Guest Editors

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