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Advances in Polymer-Based Drug-Delivery Systems

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 1780

Special Issue Editors


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Guest Editor
Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University, 28040 Madrid, Spain
Interests: drug controlled release; smart release; mucoadhesive vaginal systems; cyclodextrins; natural polymers
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
Interests: film technology; HIV/ADS prevention; mucoadhesion; topical pre-exposure prophylaxis; vaginal drug delivery
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
Interests: drug controlled release; HIV; microbicides; mucoadhesiveness; natural polymers; vaginal route
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Drug-delivery systems are continuously evolving. Advances in drug discovery imply the development of systems that allow their adequate release. In addition, the need to establish dosing regimens that increase the efficacy of current treatments, or that facilitate the day-to-day life of patients, is driving the research in this field.

In this sense, the use of polymers, whatever their nature (of natural origin, semi-synthetic derivatives or products synthesized according to requirements) offers a great opportunity to develop drug-delivery systems with unique characteristics. The versatility offered by polymers, depending on the unique characteristics of each one of them, allows us to tailor drug-delivery systems to therapeutic requirements. Thus, it is possible to design sustained release systems, biodegradable systems, mucoadhesive systems or stimuli-sensitive release systems, among others. In addition, the properties offered by these polymers can be altered by chemical or enzymatic modifications, which change the number of branches or the presence of surface charges in these polymers, thus making it possible to modify their solubility, adhesiveness, viscosity or any other characteristic that is crucial for their use in systems for the delivery of active ingredients.

In this Special Issue, we propose the compilation of the most recent research articles in which polymers are used to develop formulations for drug delivery by any possible route of administration (oral, ocular, parenteral, etc.). Studies in which modifications are made to these polymers are also welcome if they can be useful in a later application for the subject of this issue. Similarly, bibliographic reviews in which the topic of study is updated, comparing the most recent scientific advances in the field, will be considered.

Dr. Maria-Dolores Veiga
Dr. Fernando Notario-Pérez
Dr. Roberto Ruiz-Caro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioadhesion
  • controlled release
  • drug-delivery system
  • pharmaceutical technology
  • polymers
  • structural characterization
  • structural modification

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Published Papers (1 paper)

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Research

24 pages, 4740 KiB  
Article
Development and Evaluation of Oromucosal Spray Formulation Containing Plant-Derived Compounds for the Treatment of Infectious and Inflammatory Diseases of the Oral Cavity
by Yuliia Maslii, Nataliia Herbina, Lina Dene, Liudas Ivanauskas and Jurga Bernatoniene
Polymers 2024, 16(18), 2649; https://doi.org/10.3390/polym16182649 - 19 Sep 2024
Viewed by 1394
Abstract
According to data in the literature, natural products and essential oils are often used in dental practice. To develop a new oromucosal spray for the treatment of infectious and inflammatory diseases of the oral cavity, clove CO2 extract and essential oils of [...] Read more.
According to data in the literature, natural products and essential oils are often used in dental practice. To develop a new oromucosal spray for the treatment of infectious and inflammatory diseases of the oral cavity, clove CO2 extract and essential oils of lavender and grapefruit were used as active pharmaceutical ingredients. Clove extract was obtained by the method of subcritical extraction from various raw materials, the choice of which was based on the yield of the CO2 extract and the study of its phytochemical and microbiological properties. Based on the results of microscopic and diffraction analyses, the rational time of ultrasonic exposure for the emulsion of active pharmaceutical ingredients was established. Mucoadhesive polymers were used as stabilizers of the two-phase system and prolongators. This article discusses the impact of the type and concentration of mucoadhesive polymers on the stability of the emulsion system; the viscous, textural, adhesive, and film characteristics of oromucosal spray; and the parameters determining sprayability. Full article
(This article belongs to the Special Issue Advances in Polymer-Based Drug-Delivery Systems)
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