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Polymers
Special Issues
Hydrogel Materials for Drug Delivery and Tissue Engineering
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Hydrogel Materials for Drug Delivery and Tissue Engineering

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 5 January 2025 | Viewed by 11409

Special Issue Editors

Dr. Aneta Ostróżka-Cieślik

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jedności 10, 41-200 Sosnowiec, Poland
Interests: drug form technology; new drug carriers; preformulation and formulation studies; manufacturing process of liquid; semisolid and solid dosage forms
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sławomir Wilczyński

E-Mail Website
Guest Editor
Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland
Interests: pharmacy; topical drug delivery; image analysis and processing; thermography; hyperspectral imaging; biomedical engineering; bioengineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research into hydrogels and the possibility of using them for pharmaceutical and biomedical applications is one of science's most intensively developing areas. Modern hydrogel materials are structured to resemble the natural environment of cells and tissues and they are thus used in the design of effective drug carriers, surgical fillers, and cell culture media. This Special Issue will be devoted to the analysis of the physicochemical, biopharmaceutical, and mechanical properties of hydrogels with potential applications in drug delivery, tissue engineering, and regenerative medicine. Current research directions in the areas of pharmaceutical technology, polymer materials engineering, and biomedical engineering will be discussed. Our aim is to collect original papers, review papers on the development of hydrogels and hydrogel systems that can carry an active substance or can replace damaged tissues or organs. Basic, pre-clinical, and clinical research on the development of new or the development of existing hydrogel-based drugs and therapies is welcome. 

Dr. Aneta Ostróżka-Cieślik
Prof. Dr. Sławomir Wilczyński
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • hydrogels
  • drug release
  • tissue engineering
  • polymer networks

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Published Papers (5 papers)

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Research

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14 pages, 12968 KiB  
Article
Melatonin and Bacterial Cellulose Regulate the Expression of Inflammatory Cytokines, VEGF, PCNA, and Collagen in Cutaneous Wound Healing in Diabetic Rats
by Jaiurte Gomes Martins da Silva, Ismaela Maria Ferreira de Melo, Érique Ricardo Alves, Glícia Maria de Oliveira, Anderson Arnaldo da Silva, Isabela Macário Ferro Cavalcanti, Diego Neves Araujo, Flávia Cristina Morone Pinto, José Lamartine de Andrade Aguiar, Valéria Wanderley Teixeira and Álvaro Aguiar Coelho Teixeira
Polymers 2024, 16(18), 2611; https://doi.org/10.3390/polym16182611 - 15 Sep 2024
Viewed by 912
Abstract
The poor healing of diabetic wounds is characterized by prolonged inflammation and decreased collagen deposition. Diabetic patients exhibit changes in the plasma concentrations of pro-inflammatory cytokines, and the role of specific dressings may have an impact on healing. This study aims to evaluate [...] Read more.
The poor healing of diabetic wounds is characterized by prolonged inflammation and decreased collagen deposition. Diabetic patients exhibit changes in the plasma concentrations of pro-inflammatory cytokines, and the role of specific dressings may have an impact on healing. This study aims to evaluate the effects of a combined treatment comprising a bacterial cellulose dressing and melatonin application on the regulation and expression of inflammatory cytokines, VEGF, PCNA, and collagen in the healing of cutaneous wounds of diabetic rats. Pro-inflammatory cytokines, including IL-6, TNF-α, and VEGF, along with PCNA and type I and III collagen, were evaluated after 14 days. Immunohistochemistry showed decreased levels of IL-6, TNF-α, and VEGF, along with an increased expression of PCNA and type I collagen, in the groups treated exclusively with melatonin and bacterial cellulose associated with melatonin compared to the control and the commercial healing agent. It was concluded that treating the skin lesions of diabetic animals supplemented with melatonin using a bacterial cellulose-based dressing has positive effects in regulating the expression of inflammatory cytokines, vascular endothelial growth factor, and collagen, showing that this association could be a viable therapy approach in wound healing. Full article
(This article belongs to the Special Issue Hydrogel Materials for Drug Delivery and Tissue Engineering)
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11 pages, 3042 KiB  
Article
Deciphering the Effect of Hyaluronic Acid/Collagen Hydrogel for Pain Relief and Tissue Hydration in a Rat Model of Intervertebral Disc Degeneration
by Rusydi Mohd Razak, Nur Arina Amira Harizal, Mohammad Ali Zuhdi Azman, Najwa Syakirah Mohd Redzuan, Raed H. Ogaili, Ahmad Hafiz Kamarrudin, Muhammad Fakhrullah Mohamad Azmi, Nur Aqilah Kamaruddin, Aminatul Saadiah Abdul Jamil, Sabarul Afian Mokhtar and Isma Liza Mohd Isa
Polymers 2024, 16(18), 2574; https://doi.org/10.3390/polym16182574 - 11 Sep 2024
Viewed by 1559
Abstract
Intervertebral disc (IVD) degeneration is one of the primary causes of low back pain, causing disability; hence, there is no regenerative nature of the current treatments. Hyaluronic acid (HA) was reported to facilitate tissue repair and alleviate pain. Herein, we determined the therapeutic [...] Read more.
Intervertebral disc (IVD) degeneration is one of the primary causes of low back pain, causing disability; hence, there is no regenerative nature of the current treatments. Hyaluronic acid (HA) was reported to facilitate tissue repair and alleviate pain. Herein, we determined the therapeutic effect of HA and type II collagen (COLII) hydrogel for tissue repair targeting pain in IVD degeneration. We implanted HA/COLII hydrogel following surgically induced disc injury at coccygeal levels in the rat tail model of pain. We assessed the efficacy of the HA/COLII hydrogel in reducing pain behaviour by using the von Frey assessment, protein expression of growth-associated protein (GAP) 43 for sensory nerve innervation, and disc hydration by magnetic resonance imaging (MRI). We observed the anti-nociceptive effect of the HA/COLII hydrogel in alleviating mechanical allodynia in rats. There was an inhibition of sensory hyperinnervation indicated by the GAP43 protein in the treatment group. We revealed an increase in T1ρ mapping of MRI, indicating that the hydrogel restored disc hydration in vivo. Our findings suggest the HA/COLII hydrogel alleviates pain behaviour, inhibits hyperinnervation and promotes disc hydration for tissue repair, implying that it is a potential candidate for the treatment of degenerative disc-associated low back pain. Full article
(This article belongs to the Special Issue Hydrogel Materials for Drug Delivery and Tissue Engineering)
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17 pages, 7930 KiB  
Article
Evaluation of a Peptide Hydrogel as a Chondro-Instructive Three-Dimensional Microenvironment
by Rodrigo Nogoceke, Raphaella Josino, Anny Waloski Robert and Marco Augusto Stimamiglio
Polymers 2023, 15(24), 4630; https://doi.org/10.3390/polym15244630 - 6 Dec 2023
Cited by 1 | Viewed by 1230
Abstract
Articular cartilage injuries are inherently irreversible, even with the advancement in current therapeutic options. Alternative approaches, such as the use of mesenchymal stem/stromal cells (MSCs) and tissue engineering techniques, have gained prominence. MSCs represent an ideal source of cells due to their low [...] Read more.
Articular cartilage injuries are inherently irreversible, even with the advancement in current therapeutic options. Alternative approaches, such as the use of mesenchymal stem/stromal cells (MSCs) and tissue engineering techniques, have gained prominence. MSCs represent an ideal source of cells due to their low immunogenicity, paracrine activity, and ability to differentiate. Among biomaterials, self-assembling peptide hydrogels (SAPH) are interesting given their characteristics such as good biocompatibility and tunable properties. Herein we associate human adipose-derived stem cells (hASCs) with a commercial SAPH, Puramatrix™, to evaluate how this three-dimensional microenvironment affects cell behavior and its ability to undergo chondrogenic differentiation. We demonstrate that the Puramatrix™ hydrogel comprises a highly porous matrix permissible for hASC adhesion and in vitro expansion. The morphology and cell growth dynamics of hASCs were affected when cultured on the hydrogel but had minimal alteration in their immunophenotype. Interestingly, hASCs spontaneously formed cell aggregates throughout culturing. Analysis of glycosaminoglycan production and gene expression revealed a noteworthy and donor-dependent trend suggesting that Puramatrix™ hydrogel may have a natural capacity to support the chondrogenic differentiation of hASCs. Altogether, the results provide a more comprehensive understanding of the potential applications and limitations of the Puramatrix™ hydrogel in developing functional cartilage tissue constructs. Full article
(This article belongs to the Special Issue Hydrogel Materials for Drug Delivery and Tissue Engineering)
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16 pages, 2906 KiB  
Article
Hydrogel Formulations for Topical Insulin Application: Preparation, Characterization and In Vitro Permeation across the Strat-M® Membrane
by Aneta Ostróżka-Cieślik, Sławomir Wilczyński and Barbara Dolińska
Polymers 2023, 15(17), 3639; https://doi.org/10.3390/polym15173639 - 4 Sep 2023
Cited by 4 | Viewed by 2254
Abstract
Insulin has shown efficacy in the treatment of hard-to-heal wounds, which is mainly due to its role in regulating oxidative stress and inflammatory reactions. The aim of this study was to develop an insulin–hydrogel carrier based on Sepineo™ P 600 and Sepineo™ PHD [...] Read more.
Insulin has shown efficacy in the treatment of hard-to-heal wounds, which is mainly due to its role in regulating oxidative stress and inflammatory reactions. The aim of this study was to develop an insulin–hydrogel carrier based on Sepineo™ P 600 and Sepineo™ PHD 100 for application to lesional skin. Preformulation studies of the developed formulations were performed in terms of analysis of the pharmaceutical availability of insulin from the hydrogels through the Strat-M® membrane, and rheological and texture measurements. Insulin is released in a prolonged manner; after a time of 6.5 h, 4.01 IU/cm2 (53.36%) and 3.69 IU/cm2 (47.4%) of the hormone were released from the hydrogel based on Sepineo™ P 600 and Sepineo™ PHD 100, respectively. Rheological analysis showed that the hydrogels tested belong to non-Newtonian, shear-thinning systems with yield stress. The insulin–hydrogel based on Sepineo™ P 600 and Sepineo™ PHD 100 shows optimal application properties. The results obtained provide a basis for further preclinical and clinical studies. Full article
(This article belongs to the Special Issue Hydrogel Materials for Drug Delivery and Tissue Engineering)
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Review

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22 pages, 1286 KiB  
Review
Application of the Quality by Design Concept (QbD) in the Development of Hydrogel-Based Drug Delivery Systems
by S. Farid Mohseni-Motlagh, Roshanak Dolatabadi, Majid Baniassadi and Mostafa Baghani
Polymers 2023, 15(22), 4407; https://doi.org/10.3390/polym15224407 - 14 Nov 2023
Cited by 4 | Viewed by 4243
Abstract
Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such as biocompatibility, high diversity, and the possibility of administration from different routes. Despite these advantages, there are challenges, such as controlling the drug release rate and their mechanical properties during [...] Read more.
Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such as biocompatibility, high diversity, and the possibility of administration from different routes. Despite these advantages, there are challenges, such as controlling the drug release rate and their mechanical properties during the manufacturing of these systems. For this reason, there is a need for the production and development of such drug delivery systems with a scientific strategy. For this reason, the quality by design (QbD) approach is used for the development of drug delivery systems. This approach, by identifying the most effective factors in the manufacturing of pharmaceutical products and controlling them, results in a product with the desired quality with the least number of errors. In this review article, an attempt is made to discuss the application and method of applying this approach in the development of hydrogel-based drug delivery systems. So that for the development and production of these systems, according to the type of drug delivery system, what target characteristics should be considered (QTPP) and what factors, such as material properties (CMA) or process parameters (CPP), should be taken into account to reach the critical quality attributes of the product (CQA). Full article
(This article belongs to the Special Issue Hydrogel Materials for Drug Delivery and Tissue Engineering)
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