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Polymers
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Preparation of Hydrogel and Analysis of Its Suggestion in Controlled...
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Preparation of Hydrogel and Analysis of Its Suggestion in Controlled Drug Release

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 8932

Special Issue Editors

Dr. Aneta Ostróżka-Cieślik

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jedności 10, 41-200 Sosnowiec, Poland
Interests: drug form technology; new drug carriers; preformulation and formulation studies; manufacturing process of liquid; semisolid and solid dosage forms
Special Issues, Collections and Topics in MDPI journals
Dr. Małgorzata Maciążek-Jurczyk

E-Mail Website
Guest Editor
Department of Physical Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland
Interests: protein-ligand interactions; protein modification
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Research conducted in recent years indicates that hydrogels have a great potential for use as innovative controlled release drug delivery systems. Therefore this special issue will be devoted to pre-formulation, formulation, preclinical and clinical analyses of hydrogels. Current works on designing the composition and production technology of new hydrogel preparations and development studies of the existing ones will be discussed. The results of their effectiveness in the context of preclinical and clinical studies will be presented. Apart from standard (pharmacopoeial) research methods, we encourage the presentation of research results based on modern techniques and analytical methods. Our aim is to collect papers on the latest achievements in the use of hydrogels as carriers of therapeutic substances. This will allow readers to become acquainted with the current state of knowledge in this subject and the perspectives of the development of this drug form. We invite you to write a research articles, review articles as well as short communications.

Dr. Aneta Ostróżka-Cieślik
Dr. Małgorzata Maciążek-Jurczyk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel
  • preparation and optimization
  • drug delivery
  • physicochemical properties
  • in vitro and in vivo drug release
  • preformulation and formulation study
  • preclinical and clinical trials
  • spectroscopic study

Published Papers (3 papers)

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Research

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19 pages, 4798 KiB  
Article
Combined Strategy of Wound Healing Using Thermo-Sensitive PNIPAAm Hydrogel and CS/PVA Membranes: Development and In-Vivo Evaluation
by Yan Chu, Shuo Chai, Fei Li, Cuiyan Han, Xiaoyu Sui and Tingting Liu
Polymers 2022, 14(12), 2454; https://doi.org/10.3390/polym14122454 - 16 Jun 2022
Cited by 7 | Viewed by 1894
Abstract
Past studies have shown that the hot spring effect can promote wound healing. Mild thermal stimulation and metal ions can promote angiogenesis. In this study, the hot spring effect was simulated by thermosensitive PNIPAAm hydrogel loaded with copper sulfide nanoparticles. Heat stimulation could [...] Read more.
Past studies have shown that the hot spring effect can promote wound healing. Mild thermal stimulation and metal ions can promote angiogenesis. In this study, the hot spring effect was simulated by thermosensitive PNIPAAm hydrogel loaded with copper sulfide nanoparticles. Heat stimulation could be generated through near-infrared irradiation, and copper ions solution could be pulsed. On the other hand, the CS/PVA nanofiber membrane was attached to the bottom of the hydrogel to simulate the extracellular matrix structure, thus improving the wound healing ability. The CS/PVA nanofiber membrane was prepared by electrospinning, and the appropriate prescription and process parameters were determined. The nanofiber membrane has uniform pore size, good water absorption and permeability. The poor mechanical properties of PNIPAAm hydrogel were improved by adding inorganic clay. The temperature of the hydrogel loaded with CuS nanoparticles reached 40 °C under near-infrared light irradiation for 20 min, and the release rate of Cu2+ reached 26.89%. The wound-healing rate of the rats in the combined application group reached 79.17% at 13 days, demonstrating superior results over the other control groups. Histological analyses show improved inflammatory response at the healed wound area. These results indicate that this combined application approach represents a promising wound treatment strategy. Full article
(This article belongs to the Special Issue Preparation of Hydrogel and Analysis of Its Suggestion in Controlled Drug Release)
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Review

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27 pages, 3840 KiB  
Review
Hydrogel: A Potential Material for Bone Tissue Engineering Repairing the Segmental Mandibular Defect
by D S Abdullah Al Maruf, Yohaann Ali Ghosh, Hai Xin, Kai Cheng, Payal Mukherjee, Jeremy Micah Crook, Gordon George Wallace, Travis Jacob Klein and Jonathan Robert Clark
Polymers 2022, 14(19), 4186; https://doi.org/10.3390/polym14194186 - 5 Oct 2022
Cited by 14 | Viewed by 3769
Abstract
Free flap surgery is currently the only successful method used by surgeons to reconstruct critical-sized defects of the jaw, and is commonly used in patients who have had bony lesions excised due to oral cancer, trauma, infection or necrosis. However, donor site morbidity [...] Read more.
Free flap surgery is currently the only successful method used by surgeons to reconstruct critical-sized defects of the jaw, and is commonly used in patients who have had bony lesions excised due to oral cancer, trauma, infection or necrosis. However, donor site morbidity remains a significant flaw of this strategy. Various biomaterials have been under investigation in search of a suitable alternative for segmental mandibular defect reconstruction. Hydrogels are group of biomaterials that have shown their potential in various tissue engineering applications, including bone regeneration, both through in vitro and in vivo pre-clinical animal trials. This review discusses different types of hydrogels, their fabrication techniques, 3D printing, their potential for bone regeneration, outcomes, and the limitations of various hydrogels in preclinical models for bone tissue engineering. This review also proposes a modified technique utilizing the potential of hydrogels combined with scaffolds and cells for efficient reconstruction of mandibular segmental defects. Full article
(This article belongs to the Special Issue Preparation of Hydrogel and Analysis of Its Suggestion in Controlled Drug Release)
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22 pages, 1839 KiB  
Review
The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs
by Aneta Ostróżka-Cieślik
Polymers 2022, 14(16), 3307; https://doi.org/10.3390/polym14163307 - 14 Aug 2022
Cited by 6 | Viewed by 2452
Abstract
Hormones have attracted considerable interest in recent years due to their potential use in treatment of many diseases. Their ability to have a multidirectional effect leads to searching for new and increasingly effective drugs and therapies. Limitations in formulating drug forms containing hormones [...] Read more.
Hormones have attracted considerable interest in recent years due to their potential use in treatment of many diseases. Their ability to have a multidirectional effect leads to searching for new and increasingly effective drugs and therapies. Limitations in formulating drug forms containing hormones are mainly due to their low enzymatic stability, short half-life and limited bioavailability. One of the solutions may be to develop a hydrogel as a potential hormone carrier, for epidermal and transdermal application. This review discusses the main research directions in developing this drug formulation. The factors determining the action of hormones as drugs are presented. An analysis of hydrogel substrates and permeation enhancers that have the potential to enhance the efficacy of hormones applied to the skin is reviewed. Full article
(This article belongs to the Special Issue Preparation of Hydrogel and Analysis of Its Suggestion in Controlled Drug Release)
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