Advances in Natural Biodegradable Polymers

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Circular and Green Polymer Science".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 557

Special Issue Editors


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Guest Editor
School of Food Science and Engineering, South China University of Technology, Guangzhou, China
Interests: biopolymers; polysaccharides; biodegradable; polymer composites; hydrogels

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Guest Editor
School of Light Industry and Food Engineering, Guangxi University, Nanning, China
Interests: polymer chemistry; food preservation; food science; microbiology

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Guest Editor
School of Food Science and Engineering, South China University of Technology, Guangzhou, China
Interests: biopolymers; polysaccharides; biodegradable; polymer composites; hydrogel

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Guest Editor
State Key Laboratory of Bio-fibers, Eco-textiles Institute of Biochemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China
Interests: biodegradable polymers; copolymers and nanocomposites; biochemical engineering; biopolymers; colloids and interfaces; enzyme immobilization; biorefinery; enzymatic polymerization
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Special Issue Information

Dear Colleagues,

Increasing environmental concerns and the increasing need for sustainable materials have driven significant interest in natural biodegradable polymers. These polymers, derived from renewable resources, offer an eco-friendly alternative to traditional synthetic polymers. They find applications across various fields, including packaging, agriculture, biomedical engineering, and more. This Special Issue aims to highlight recent advancements in the synthesis, characterization, and application of natural biodegradable polymers, promoting innovative research that addresses both performance and environmental sustainability.

We welcome original research articles, reviews, and communications on topics including, but not limited to, the following:

  • Synthesis and processing of natural biodegradable polymers;
  • Characterization of mechanical, thermal, and biodegradation properties;
  • Applications in packaging, agriculture, antibacterial, and biomedical fields;
  • Development of bio-based composites;
  • Advances in green and sustainable polymer technologies;
  • Chitosan, cellulose, pectin and Starch for sustainable packaging and other fields.

We look forward to your valuable contributions to this Special Issue, which will advance the knowledge and application of natural biodegradable polymers in various industries.

Dr. Qingfei Duan
Dr. Fengsong Liu
Dr. Zuman Dou
Prof. Dr. Chunzhao Liu
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural biodegradable polymers
  • chitosan
  • cellulose
  • pectin
  • sustainability
  • renewable resources
  • eco-friendly materials
  • bio-composites
  • green technology
  • biocompatibility
  • biodegradability

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Published Papers (1 paper)

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Research

21 pages, 58464 KiB  
Article
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition
by Xin Li, Chuanyu Tang, Hanjie Ye and Chihua Fang
Polymers 2024, 16(17), 2418; https://doi.org/10.3390/polym16172418 - 26 Aug 2024
Viewed by 439
Abstract
Lenvatinib resistance (LenR) presents a significant challenge in hepatocellular carcinoma (HCC) treatment, leading to high cancer-related mortality rates globally. Unlike traditional chemotherapy resistance mechanisms, LenR in HCC is primarily driven by increased cancer cell stemness. Disulfiram, (DSF), functioning as a Cu ionophore, can [...] Read more.
Lenvatinib resistance (LenR) presents a significant challenge in hepatocellular carcinoma (HCC) treatment, leading to high cancer-related mortality rates globally. Unlike traditional chemotherapy resistance mechanisms, LenR in HCC is primarily driven by increased cancer cell stemness. Disulfiram, (DSF), functioning as a Cu ionophore, can coordinate with Cu2+ to overcome LenR in HCC by inhibiting cancer cell stemness and cuproptosis. However, DSF faces challenges due to its poor water solubility, while copper ions present issues related to systemic toxicity during widespread use. To address this, DSF and CuO nanoparticles (NPs) were co-encapsulated to form an oil-in-water Pickering emulsion (DSF@CuO), effectively elevating DSF and copper ion concentrations within the tumor microenvironment (TME). DSF@CuO was then combined with sodium alginate (SA) to form a DSF@CuO-SA solution, which gelatinizes in situ with Ca2+ in the TME to form a DSF@CuO Gel, enhancing Pickering emulsion stability and sustaining DSF and copper ion release. A DSF@CuO Gel exhibits enhanced stability and therapeutic efficacy compared to conventional administration methods. It effectively induces mitochondrial dysfunction and cuproptosis in LenR HCC cells by downregulating DLAT, LIAS, and CDKN2A, while upregulating FDX1. Furthermore, it suppresses cancer stemness pathways through activation of the JNK/p38 MAPK pathway and inhibition of the NF-κB and NOTCH signaling pathways. These findings suggest that DSF@CuO Gels are a promising therapeutic strategy for treating LenR HCC. In vivo and in vitro LenR HCC models demonstrated significant therapeutic efficacy. In conclusion, this novel approach underscores DSF@CuO Gel’s potential to overcome LenR in HCC, offering a novel approach to address this clinical challenge. Full article
(This article belongs to the Special Issue Advances in Natural Biodegradable Polymers)
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