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Polymers
Special Issues
Polymers: Application in Cancer Nanotheranostics, Especially Drug Delivery
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Polymers: Application in Cancer Nanotheranostics, Especially Drug Delivery

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 2473

Special Issue Editors

Dr. Marzieh Salimi

E-Mail Website
Guest Editor
School of Physics and Astronomy, University of Exeter, Exeter EX4 4QL, UK
Interests: nanoparticles; breast cancer; nanocarriers; radiobiology; photothermal therapy; particle therapy; magnetic hyperthermia; radiation safety; non-ionizing radiation
Dr. Shreyas Kuddannaya

E-Mail Website
Guest Editor
Cellular Imaging Section-Institute for Cell Engineering, Department of Radiology, Johns Hopkins University-School of Medicine, Baltimore, MD 21205, USA
Interests: stem cell therapy; cell transplantation; in vivo imaging; neuro-regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a great pleasure to present this Special Issue, "Polymers: Application in cancer nanotheranostics, especially drug delivery", which will allow polymer researchers to submit research papers and reviews on this topic.

Nanotheranostic platforms using different nanoparticles to perform diagnostics and treatment have become a potential approach for future cancer management. The coating of nanoparticles with polymers seems essential to serve nanoparticles’ biocompatibility and drug-loading properties. We also aim to show the critical role of polymers in drug delivery systems as a cancer therapeutic strategy. Other therapeutic approaches can include magnetic hyperthermia, radiation therapy, and photothermal therapy using polymeric nanoparticles. 

This Special Issue of Polymers is dedicated to the applications of polymers in cancer nanotheranostics, especially drug delivery. We invite researchers to submit papers aiming at the development of nanoparticles using polymers in cancer diagnostics, such as Raman spectroscopy, magnetic resonance imaging, computed tomography, magnetic particle imaging, and therapeutics. The submission of subdiscipline-specific reviews is also welcome.

We look forward to receiving your contributions.

Dr. Marzieh Salimi
Dr. Shreyas Kuddannaya
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymers
  • nanoparticles
  • cancer
  • therapeutics
  • diagnostics
  • drug delivery
  • theranostics

Published Papers (1 paper)

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Research

12 pages, 3226 KiB  
Article
Assessment of Oxaliplatin-Loaded Iodine Nanoparticles for Chemoradiotherapy of Human Colorectal Cancer (HT-29) Cells
by Naser Rasouli, Daryoush Shahbazi-Gahrouei, Simin Hematti, Behzad Baradaran, Roya Salehi, Jaleh Varshosaz and Abbas Jafarizad
Polymers 2022, 14(19), 4131; https://doi.org/10.3390/polym14194131 - 2 Oct 2022
Cited by 6 | Viewed by 1869
Abstract
Colorectal cancer is highly prevalent worldwide and has significant morbidity and mortality in humans. High-atomic-number nanoparticles such as iodine can act as X-rays absorbers to increase the local dose. The synthesis and fabrication of oxaliplatin-loaded iodine nanoparticles, their characterization, cell toxicity, radiosensitivity, cell [...] Read more.
Colorectal cancer is highly prevalent worldwide and has significant morbidity and mortality in humans. High-atomic-number nanoparticles such as iodine can act as X-rays absorbers to increase the local dose. The synthesis and fabrication of oxaliplatin-loaded iodine nanoparticles, their characterization, cell toxicity, radiosensitivity, cell apoptosis, and cell cycle assay in human colorectal cancer (HT-29) cells are investigated. Results show that the synthesis of a new iodine nanoparticle, polymerized triiodobenzene coated with chitosan and combined with oxaliplatin as a chemotherapeutic drug, performed well in vitro in an intracellular radiosensitizer as chemoradiotherapy agent in HT-29 cell lines. Findings also show that the INPs alone have no impact on cell cycle development and apoptosis. In contrast, oxaliplatin-loaded INPs along with 2 and 6 MV radiation doses produced more apoptosis. The interaction of INPs with mega-voltage photon energies is the cause of a major radiosensitization enhancement in comparison to radiation alone. Furthermore, results show that INPs may work as radiosensitization nanoprobe agents in the treatment of HT-29 cells due to their effect on increasing radiation dose absorption. Overall, iodine nanoparticles may be used in the treatment of colorectal cancers in clinical studies. Full article
(This article belongs to the Special Issue Polymers: Application in Cancer Nanotheranostics, Especially Drug Delivery)
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