Polymers for Diagnostics and Therapy
A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Chemistry".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 15677
Special Issue Editors
Interests: biomaterials; fluid dynamics
Special Issues, Collections and Topics in MDPI journals
Interests: valve surgery; coronary surgery; aortic surgery; cardiac biomechanics; tissue biomodelling; tissue engineering; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The use of bioresorbable vascular stents (BVSs) in clinical practice has been proposed as a solution to drug-eluting stents (DESs) to avoid the complication of intra-stent restenosis, which represents the failure of the PCI procedure. A bioresorbable vascular stent can consist of the combination of PLGA or poly (lactic-co-glycolic) or poly-D, L-lactide (PDLLA) with everolimus. Another BVS is comprised of a magnesium-based scaffold which resorbs within one year of implantation and has been approved for use in several countries around the world. The main point in favor of the BVS was the fact that once the material was reabsorbed the coronary artery would be completely free of a footprint, which has proved to be a problem when a possible second surgical time would be useful. Although data from several ABSORB trials statistically showed good performance compared to the market-leading Xience everolimus-eluting metallic stent, there was signal in the data for slightly poorer outcomes, negating any long-term benefits the stent might offer. Experts involved in the trials said ABSORB saw a very low usage rate, with estimates in the U.S. showing usage of less than 5%.
It is evident that given the rapid development and use of BVSs, it is becoming increasingly important to understand the relationship among the structure of vascular atheromatous plaque, processing, and properties of biomedical polymers so as to widen their medical applications and improve the characteristics of the materials already used.
This Special Issue “Polymers for Diagnostics and Therapy” highlights the importance of polymers used in the biomedical field. The topics of interest concern the polymers (biodegradable or not) used for this purpose and related aspects, such as replacement materials for heart valves and arteries, ultrahigh-molecular-weight polyethylene (UHMWPE) in joint replacement, tissue engineering scaffolds, drug delivery systems, sutures, etc.
Dr. Domenico Larobina
Dr. Francesco Nappi
Guest Editors
Manuscript Submission Information
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