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Polymers
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Stimuli-Responsive Polymer Materials for Biomedical Applications
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Stimuli-Responsive Polymer Materials for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 5205

Special Issue Editors

Prof. Dr. Chao Yin

E-Mail Website
Guest Editor
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, China
Interests: design and synthesis of multifunctional nanomaterials; organic semiconducting polymers/oligomers for biomedical applications; organic/inorganic hybrid nano-materials; biological imaging; biosensor
Prof. Dr. Chen Xie

E-Mail Website
Guest Editor
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, China
Interests: optical imaging and cancer therapy; organic conjugated materials for tumor imaging and treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stimuli-responsive polymers, or so-called “smart polymers”, are macromolecules that are sensitive to certain triggers from the external environment, including temperature, light, electrical or magnetic fields, and chemicals. These polymer materials, such as photoactive polymers, naturally active polymers, biologically endogenous macromolecules, and biomimetic materials, etc., have been widely explored for biomedical applications, especially for bio-sensing and disease diagnosis, owing to their activatable behavior toward biologically relevant stimuli. The aim of this Special Issue is to introduce the cutting-edge research progress on stimuli-responsive polymer materials and their biomedical applications, which involves the advanced material chemistry, efficient analytical methods, innovative imaging, and therapeutic techniques, and the development of high-efficiency biosensors for preclinical and clinical theranostics.

This Special Issue will publish original research articles and review papers which will present current high-impact research topics or directions, as well as future perspectives in stimuli-responsive polymer materials for biomedical applications. The desired topics of this Special Issue include but are not limited to chemistry, materials, biomedicine, and devices, such as: (i) design and fabrication of activatable polymers; (ii) advanced diagnostic and therapeutic approaches toward life-threatening diseases; (iii) advanced bio-sensing systems for disease screening; and (iv) clinical translation technologies for such “smart polymers”.

Prof. Dr. Chao Yin
Prof. Dr. Chen Xie
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stimuli-responsive polymer
  • nanoparticle
  • hydrogel
  • photoacoustic imaging
  • fluorescence imaging
  • phototherapy
  • surgery
  • chemotherapy
  • bio-sensing
  • theranostic system

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Published Papers (2 papers)

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Research

10 pages, 1653 KiB  
Article
Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide
by Moonhyun Choi, Arman Moini Jazani, Jung Kwon Oh and Seung Man Noh
Polymers 2022, 14(11), 2240; https://doi.org/10.3390/polym14112240 - 31 May 2022
Cited by 5 | Viewed by 2219
Abstract
Nitric oxide (NO) plays a critical role as an important signaling molecule for a variety of biological functions, particularly inhibiting cell proliferation or killing target pathogens. To deliver active radical NO gaseous molecule whose half-life is a few seconds in a stable state, [...] Read more.
Nitric oxide (NO) plays a critical role as an important signaling molecule for a variety of biological functions, particularly inhibiting cell proliferation or killing target pathogens. To deliver active radical NO gaseous molecule whose half-life is a few seconds in a stable state, the design and development of effective exogenous NO supply nanocarriers are essential. Additionally, the delivery of desired drugs with NO can produce synergistic effects. Herein, we report a new approach that allows for the fabrication of dual ultrasound (US)/glutathione (GSH)-responsive perfluorocarbon (PFC) nanodroplets for the controlled release of model drug and passive release of safely incorporated NO. The approach centers on the synthesis of a disulfide-labeled amphiphilic block copolymer and its use as a GSH-degradable macromolecular emulsifier for oil-in-water emulsification process of PFC. The fabricated PFC nanodroplets are colloidally stable and enable the encapsulation of both NO and model drugs. Encapsulated drug molecules are synergistically released when ultrasound and GSH are presented, while NO molecules are passively but rapidly released. Our preliminary results demonstrate that the approach is versatile and can be extended to not only GSH-responsive but also other stimuli-responsive block copolymers, thereby allowing for the fabrication of broad choices of stimuli-responsive (smart) PFC-nanodroplets in aqueous solution for dual delivery of drug and NO therapeutics. Full article
(This article belongs to the Special Issue Stimuli-Responsive Polymer Materials for Biomedical Applications)
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14 pages, 4787 KiB  
Article
In Situ-Forming Cellulose/Albumin-Based Injectable Hydrogels for Localized Antitumor Therapy
by Ying Chen, Xiaomin Wang, Yudong Huang, Peipei Kuang, Yushu Wang, Yong Liu, Weihan Yin, Jiahui Zan, Yupeng Liu, Chao Yin and Quli Fan
Polymers 2021, 13(23), 4221; https://doi.org/10.3390/polym13234221 - 1 Dec 2021
Cited by 7 | Viewed by 2425
Abstract
Injectable hydrogels, which are formed in situ by changing the external stimuli, have the unique characteristics of easy handling and minimal invasiveness, thus providing the advantage of bypass surgical operation and improving patient compliance. Using external temperature stimuli to realize the sol-to-gel transition [...] Read more.
Injectable hydrogels, which are formed in situ by changing the external stimuli, have the unique characteristics of easy handling and minimal invasiveness, thus providing the advantage of bypass surgical operation and improving patient compliance. Using external temperature stimuli to realize the sol-to-gel transition when preparing injectable hydrogel is essential since the temperature is stable in vivo and controllable during ex vivo, although the hydrogels obtained possibly have low mechanical strength and stability. In this work, we designed an in situ fast-forming injectable cellulose/albumin-based hydrogel (HPC-g-AA/BSA hydrogels) that responded to body temperature and which was a well-stabilized hydrogen-bonding network, effectively solving the problem of poor mechanical properties. The application of localized delivery of chemotherapeutic drugs of HPC-g-AA/BSA hydrogels was evaluated. In vitro and in vivo results show that HPC-g-AA/BSA hydrogels exhibited higher antitumor efficacy of reducing tumor size and seem ideal for localized antitumor therapy. Full article
(This article belongs to the Special Issue Stimuli-Responsive Polymer Materials for Biomedical Applications)
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