Polymer Applications in Regenerative Medicine

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 3520

Special Issue Editor


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Guest Editor
Department of Chemistry, University College London, London WC1H 0AJ, UK
Interests: electrochemistry and materials science
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Special Issue Information

Dear Colleagues,

Applications and detections of polymers play important roles in the development of clinical medicine, bioengineering, bio-fabrication, tissue engineering and regenerative medicine, which impact the novel biomaterials synthesis, cell gene expression, signal pathways transition, etc.

In recent years, polymers have exhibited promising structures and functions as bioactive scaffolds for tissue regeneration, and their bioactive nature allows cells or tissue cultured on them to be stimulated by related signal pathways. Therefore, polymeric composites based on small molecules, natural or synthetic polymers, and biocompatible biodegradable polymers were quickly developed. On the other hand, novel detection techniques for polymers is also an important field, which decides the biomaterial representation and disease discovery and evaluation.

The major objective of this Special Issue is to recruit polymer-related research used in tissue engineering and regenerative medicine, including nanofibers, hydrogels, scaffolds, etc., produced by various methods such as 3D bioprinting, electrospinning, freeze drying, coating, etc.. Furthermore, recent progress of these biomaterials in skin tissue engineering, vessel tissue engineering, urethra tissue engineering, organoid, and wound healing applications will be considered. Novel detection techniques for natural and synthetic polymers from basic research and clinical application are needed.

Dr. Wenyao Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polymers
  • Electrospinning
  • 3D bioprinting
  • Hydrogel
  • Component analysis
  • Basic research
  • Clinical application
  • Tissue engineering
  • Biomaterial

Published Papers (1 paper)

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Research

20 pages, 5482 KiB  
Article
Effect of Gamma Irradiation on Enhanced Biological Activities of Exopolysaccharide from Halomonas desertis G11: Biochemical and Genomic Insights
by Habib Chouchane, Sahar Boutiti, Awatef Ouertani, Wafa Hassen, Sihem Guesmi, Mohamed Neifar, Haikel Jelassi, Haïtham Sghaier, Ahmed Salah Eddine Masmoudi and Ameur Cherif
Polymers 2021, 13(21), 3798; https://doi.org/10.3390/polym13213798 - 2 Nov 2021
Cited by 7 | Viewed by 1991
Abstract
In this work, a native exopolysaccharide (nEPS) produced by Halomonas desertis G11 isolated from a Tunisian extreme environment was modified by gamma irradiation. Characterization as well as the antioxidant and antitumor activities of nEPS and its gamma-irradiated derivatives (iEPSs) were comparatively evaluated. In [...] Read more.
In this work, a native exopolysaccharide (nEPS) produced by Halomonas desertis G11 isolated from a Tunisian extreme environment was modified by gamma irradiation. Characterization as well as the antioxidant and antitumor activities of nEPS and its gamma-irradiated derivatives (iEPSs) were comparatively evaluated. In vitro and in vivo antioxidant potentials were determined by using different methods and through different antioxidant enzymes. The antitumor activity was checked against a human colon cancer cell line. Analyses of the complete genome sequence were carried out to identify genes implicated in the production of nEPS. Thus, the genomic biosynthesis pathway and the export mechanism of nEPS were proposed. Analyses of irradiation data showed that iEPSs acquired new functional groups, lower molecular weights, and gained significantly (p < 0.05) higher antioxidant and antitumor abilities compared with nEPS. These findings provide a basis for using iEPSs as novel pharmaceutical agents for human therapies. Full article
(This article belongs to the Special Issue Polymer Applications in Regenerative Medicine)
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