Polymeric Nanoparticles for Bioapplications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 3325

Special Issue Editors


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Guest Editor
Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan
Interests: nanomaterials; biosensors; photonics; soft matters

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Guest Editor
Graduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University, Taipei, Taiwan
Interests: biomaterials; drug delivery; tissue engineering
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Special Issue Information

Dear Colleagues,

In recent years, nanotechnologies have led to tremendous achievements and breakthroughs in the field of diagnostics, therapeutics, biotechnologies, bioengineering, imaging, and optics applications. The recent development of nanosized systems through the tailoring of macromolecules is a current topic of interest. The extraordinary characteristics of nanoparticles are of considerable significance and differ from bulk materials in high surface-area-to-volume ratio, particle size, and so on. There is a vast demand for tailor-made functional nanoparticular materials such as organic, inorganic, or hybrid nanoparticles. The materials used in various fields of applications such as medicine, biotechnologies, pharmaceuticals, catalysis, and analysis are overwhelming. This Special Issue will center on the development of polymeric nanoparticles for bioengineering medical-based applications.

Dr. Yu-Cheng Hsiao
Dr. Er-Yuan Chuang
Guest Editors

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Keywords

  • Nanoparticles
  • Biomedical
  • Polymeric materials
  • Nanomaterials
  • Bioapplications

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Published Papers (1 paper)

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Research

11 pages, 2964 KiB  
Article
Hemoglobin-Conjugated Gold Nanoclusters for Qualitative Analysis of Haptoglobin Phenotypes
by Shih-Hua Tan, Sibidou Yougbaré, Hsueh-Liang Chu, Tsung-Rong Kuo and Tsai-Mu Cheng
Polymers 2020, 12(10), 2242; https://doi.org/10.3390/polym12102242 - 29 Sep 2020
Cited by 3 | Viewed by 2945
Abstract
Designing a facile and rapid detection method for haptoglobin (Hp) phenotypes in human blood plasma is urgently needed to meet clinic requirements in hemolysis theranostics. In this work, a novel approach to qualitatively analyze Hp phenotypes was developed using a fluorescent probe of [...] Read more.
Designing a facile and rapid detection method for haptoglobin (Hp) phenotypes in human blood plasma is urgently needed to meet clinic requirements in hemolysis theranostics. In this work, a novel approach to qualitatively analyze Hp phenotypes was developed using a fluorescent probe of gold nanoclusters (AuNCs). Hemoglobin-conjugated (Hb)-AuNCs were successfully synthesized with blue-green fluorescence and high biocompatibility via one-pot synthesis. The fluorescence of Hb-AuNCs comes from the ligand-metal charge transfer between surface ligands of Hb and the gold cores with high oxidation states. The biocompatibility assays including cell viability and fluorescence imaging, demonstrated high biocompatibility of Hb-AuNCs. For the qualitative analysis, three Hp phenotypes in plasma, Hp 1-1, Hp 2-1, and Hp 2-2, were successfully discriminated according to changes in the fluorescence intensity and peak position of the maximum intensity of Hb-AuNCs. Our work provides a practical method with facile and rapid properties for the qualitative analysis of three Hp phenotypes in human blood plasma. Full article
(This article belongs to the Special Issue Polymeric Nanoparticles for Bioapplications)
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