Developmental Neurotoxicity Induced by Chemical Mixtures

Dear Colleagues,

In the field of neurotoxicology, it is common to study the effects of suspected toxicants on neural development/functioning in isolation. This is typically done to gain better insight into the precise mechanism of action of individual compounds. However, this method of singular exposure is typically not consistent with our actual experience, as our external environments often expose us to combinations of different toxicants. Additionally, research has shown that the effects of many of these toxicants in isolation can be different from effects of combined exposures. Even when individual compounds cause maladaptive outcomes, toxicant mixtures can result in additive effects, unpredictable synergistic effects, or even null findings. As critical or sensitive periods of development are associated with greater susceptibility, in this Special Issue, we are especially interested in the neural and behavioral effects of chemical mixtures during the prenatal, peri/neonatal, or adolescent periods. We encourage studies using either human or animal models and those that include male and female subjects. Your contribution is appreciated and will add to the existing body of clinically relevant literature in the field of neurotoxicology.

Dr. Jari Willing
Guest Editor

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• toxicant mixtures
• neurodevelopment
• synergistic effects
• additive effects
• prenatal
• perinatal
• adolescence
• neurotoxicology