Endocrine-Disrupting Chemicals and Reproductive Toxicology

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 597

Special Issue Editor


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Guest Editor
Department of Physiology and Toxicology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
Interests: pesticides; endocrine disruptors; environmental toxicology; reproductive disorders; myometrial contractions

Special Issue Information

Dear Colleagues,

Chemical products are indispensable in modern everyday life.  They are a varied and broad group with many different benefits. However, after bioaccumulation in living organisms, they can act as endocrine disruptors and can pose risks to domestic animal or human reproduction.

This Special Issue aims to contribute to novel research on the cellular and molecular mechanisms of endocrine-disrupting chemicals and how they impact reproduction. We encourage the study of currently used chemicals and their metabolites, as well as protection products that are commonly recognized as persistent environmental contaminants and have been banned previously. This can improve their risk assessment, but also potentially aid in finding substances with beneficial effects on reproduction.

Papers may include, but are not limited to, the following topics: the molecular or epigenetic mechanisms behind the toxicity of chemicals; disorders related to the receptivity and further signal transmission of reproductive hormones; in vitro studies; and/or predictive or computational reproductive toxicology approaches.

Authors are invited and welcome to submit original research papers, reviews, short communications, and case reports. 

Dr. Michał Hubert Wróbel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive toxicology
  • endocrine disruptors
  • environmental pollutions
  • parabens
  • pesticides
  • plastic
  • phthalates
  • metals
  • polychlorinated biphenyls
  • polybrominated compounds

Published Papers (1 paper)

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Research

18 pages, 2503 KiB  
Article
Reproductive and Developmental Effects of Sex-Specific Chronic Exposure to Dietary Arsenic in Zebrafish (Danio rerio)
by Mahesh Rachamalla, Arash Salahinejad, Vladimir Kodzhahinchev and Som Niyogi
Toxics 2024, 12(4), 302; https://doi.org/10.3390/toxics12040302 - 19 Apr 2024
Viewed by 471
Abstract
The present study investigated the reproductive and developmental effects of sex-specific chronic exposure to dietary arsenic in zebrafish. Adult zebrafish (Danio rerio) were exposed to environmentally realistic doses of arsenic via diet [0 (control; no added arsenic), 30 (low), 60 (medium), [...] Read more.
The present study investigated the reproductive and developmental effects of sex-specific chronic exposure to dietary arsenic in zebrafish. Adult zebrafish (Danio rerio) were exposed to environmentally realistic doses of arsenic via diet [0 (control; no added arsenic), 30 (low), 60 (medium), and 100 (high) μg/g dry weight, as arsenite] for 90 days. Following exposure, arsenic-exposed females from each dietary treatment were mated with control males, and similarly, arsenic-exposed males from each dietary treatment were mated with control females. In females, arsenic exposure resulted in a dose-dependent decrease in reproductive performance (fecundity, fertilization success, and hatching success). Moreover, a dose-dependent increase in developmental toxicity (larval deformities and larval mortality) was observed with maternal exposure to arsenic. In contrast, in males, arsenic exposure also induced similar reproductive and developmental toxicity; however, the adverse effects were mainly evident only in the medium and high dietary arsenic treatment groups. We also examined the sex-specific effects of dietary arsenic exposure on the expression of genes that regulate the hypothalamus–pituitary–gonadal–liver (HPG-L) axis in fish. The gene expression results indicated the downregulation of HPG-L axis genes in females irrespective of the arsenic treatment dose; however, the reduced expression of HPG-L axis genes in males was recorded only in the medium and high arsenic treatment groups. These observations suggest that chronic arsenic exposure in either females or males causes reproductive and developmental toxicity in zebrafish. However, these toxic effects are markedly higher in females than in males. Our results also suggest that arsenic can act as an endocrine disruptor and mediate reproductive and developmental toxicity by disrupting the HPG-L axis in zebrafish. Full article
(This article belongs to the Special Issue Endocrine-Disrupting Chemicals and Reproductive Toxicology)
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