The Neuroexposome: Integrating Exposures with Physiology to Understand Brain Health and Disease

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 12

Special Issue Editors


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Guest Editor
Comparative Biosciences, University of Illinois Urbana Champaign, Urbana, IL 61802, USA
Interests: sex differences; behavior; neurotoxicology; phthalates; mixtures; pesticides; cognition; anxiety section; exposome analysis and risk assessment

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Guest Editor
School of Health Sciences, Purdue University, 550 Stadium Mall Dr., HAMP-1163D, West Lafayette, IN 47907, USA
Interests: environmental and molecular toxicology; developmental origin of health and disease; genome and epigenome alterations; molecular cytogenetics; neurotoxicology; toxicogenomics; zebrafish model system
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Special Issue Information

Dear Colleagues,

The brain can be exquisitely sensitive to environmental exposures, particularly during periods of development. However, exposures occurring across the lifespan, from conception to old age, can impact the nervous system, resulting in neuroanatomical changes, compromised neural functions, and the development of disease. Exposures such as air pollution, chemicals, plasticizers, and heavy metals can lead to the occurrence of neurodevelopmental disorders, neurodegenerative diseases, and neuropsychiatric conditions. Furthermore, there is potential for environmental exposures to have a significant impact on brain health in individuals that are already susceptible to disease, such as those with a genetic predisposition and those experiencing psychosocial stressors. The “neuroexposome” can be described as the neurophysiological outcomes which occur as a result of the sum of the internal and external exposures experienced by an individual. Research in this area will provide important insights into how our environment shapes the onset and progression of brain disease and provide potential avenues for intervention. Thus, the goal of this Special Issue is to examine the relationships between environmental exposures and endogenous factors which lead to brain dysfunction and disease states, including neurodevelopmental conditions such as autism, neurodegenerative diseases including Parkinson’s or Alzheimer’s disease, or neuropsychiatric conditions. We invite original research articles or reviews in this area.

Dr. Megan Mahoney
Dr. Jennifer L. Freeman
Guest Editors

Manuscript Submission Information

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Keywords

  • exposome
  • exposomics
  • neuroexposome
  • neurodegeneration
  • neurotoxicology
  • neurodevelopment
  • developmental origins of health and disease (DOHAD)

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This special issue is now open for submission.
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