Mechanisms and Biomarkers for Drug and Chemical Toxicity: Recent In Vitro and In Vivo Studies
A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Novel Methods in Toxicology Research".
Deadline for manuscript submissions: closed (25 May 2023) | Viewed by 3029
Special Issue Editors
Interests: hepatotoxicity; biomarker; microRNAs; hepatocytes; toxicology; microphysiological systems
Special Issue Information
Dear Colleagues,
The knowledge in drug and chemical toxicity is rapidly growing. New in vitro and in vivo models are being developed or refined to facilitate the study of drug and chemical toxicity. Some examples include induced pluripotential stem cell-derived cardiomyocytes and hepatocytes, microphysiological systems, and humanized mice. Advanced analytic approaches, such as next-generation sequencing, are being incorporated in toxicity studies. As result, novel mechanisms and biomarkers are emerging to better understand or predict drug and chemical toxicity. This Special Issue aims to put together a collection of articles focusing on the underlying mechanisms and potential biomarkers of drug and chemical toxicity identified with recently developed in vitro and in vivo models or analytic methods. Translational studies using human-relevant doses or which provide insights into species differences are particularly welcome. Priority will also be given to studies on drugs or chemicals that have very recently been introduced to the market, regardless of the methodologies used. Additional topics include the characterization of novel models or biomarkers. Both research and review articles will be considered.
Dr. Qiang Shi
Dr. Li Pang
Guest Editors
Manuscript Submission Information
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Keywords
- toxicity
- biomarkers
- mechanisms
- safety assessment
- hepatotoxicity
- cardiotoxicity
- microphysiological systems
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