Pregnancy and Lactation Period Exposure to Environmental Toxicants and the Effects on Maternal and Child Health

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".

Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 1264

Special Issue Editors


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Guest Editor
School of Public Health, Lanzhou University, Lanzhou 730000, China
Interests: environment exposure; perinatal period; maternal and child health; environmental toxicology; mitochondrial homeostasis
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Centre for Molecular Bioscience, University of Ulster, Coleraine BT52 1SA, UK
Interests: pathology; toxic substances on the fetus and the infant
School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Interests: environmental exposure; maternal and child health; fetal and infant neurodevelopment; environmental epidemiology; heavy metals; sleep hygiene

Special Issue Information

Dear Colleagues,

The Special Issue “Pregnancy and Lactation Period Exposure to Environmental Toxicants and the Effects on Maternal and Child Health” presents a comprehensive collection of cutting-edge research examining the long-term health consequences of maternal exposure to environmental contaminants during critical prenatal development windows. This issue explores how diverse pollutants, including heavy metals (lead, mercury), persistent organic pollutants (PCBs, DDT), endocrine disruptors (phthalates, bisphenol A), and emerging contaminants (microplastics, PFAS), influence fetal development and shape childhood health trajectories. By integrating biomonitoring data, epidemiological evidence, and mechanistic insights, this platform bridges the gap between pregnancy and lactation period environmental exposure assessment and maternal and child health outcomes.

A key focus is the identification of vulnerable windows through biomarker discovery, alongside investigations of molecular pathways such as placental transport mechanisms, fetal hypoxia, metabolic reprogramming, epigenetic modifications, oxidative stress, and immune dysregulation. The issue particularly welcomes contributions that employ advanced methodologies, including multi-omics approaches, network toxicology, computational modeling, and innovative risk assessment frameworks, to inform policy development for reducing pregnancy and lactation period exposure risks. Emphasis is placed on translating scientific findings into actionable strategies for safeguarding maternal and child health, with the overarching goal of advancing interdisciplinary approaches to address this critical global public health challenge.

Prof. Dr. Lin Zhang
Dr. C. Vyvyan Howard
Dr. Ju Wang
Guest Editors

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Keywords

  • pregnancy and lactation period exposure
  • environmental toxicants
  • maternal and child health
  • biomarkers
  • molecular mechanism
  • advanced methodologies
  • multi-omics techniques
  • network toxicology
  • computational modeling
  • risk assessment

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Published Papers (1 paper)

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Research

17 pages, 4675 KB  
Article
Maternal Exposure to 2,4-Di-tert-butylphenol During Pregnancy in a Mouse Model Leads to Abnormal Development of the Urinary System in Offspring
by Yuanyan Jiang, Ningli Ye, Minghui Yu, Haixin Ju, Chunyan Wang, Hengmin Wang, Jiaojiao Liu, Qian Shen and Hong Xu
Toxics 2025, 13(11), 991; https://doi.org/10.3390/toxics13110991 - 18 Nov 2025
Viewed by 836
Abstract
The occurrence of congenital anomalies of the kidney and urinary tract (CAKUT) is influenced by intrauterine environmental factors, and maternal exposure to endocrine-disrupting chemicals (EDCs) during pregnancy may affect the kidney development of offspring. 2,4-Di-tert-butylphenol (2,4-DTBP) is a high-production volume chemical classified as [...] Read more.
The occurrence of congenital anomalies of the kidney and urinary tract (CAKUT) is influenced by intrauterine environmental factors, and maternal exposure to endocrine-disrupting chemicals (EDCs) during pregnancy may affect the kidney development of offspring. 2,4-Di-tert-butylphenol (2,4-DTBP) is a high-production volume chemical classified as an EDC, which has been detected in humans and has been found to increase mortality and malformation rates in zebrafish embryos. Its effects on mammalian development are still unknown. In this study, a maternal mouse model exposed to 2,4-DTBP throughout pregnancy was established by gavage. The overall conditions of the maternal mice and their offspring were observed, and the concentrations of 2,4-DTBP in maternal serum and offspring tissues were measured using liquid chromatography–tandem mass spectrometry. Exposure to 2,4-DTBP of 75 µg/g·day during pregnancy markedly reduced the early pregnancy rate in mice to 41.75% (95% CI: 33.53–49.97%; n = 139), compared to 82.29% (95% CI: 74.18–90.39%; n = 85) in the controls (p < 0.0001), with a relative risk (RR) of 0.51 (95% CI: 0.41–0.63). 2,4-DTBP could accumulate in maternal mice and be transferred to embryos and internal organs of the offspring, and is associated with the elevated risk of CAKUT in the offspring, primarily manifesting as hydronephrosis/ureteral dilation. The CAKUT rate of DTBP-75 group is 33.59% (95% CI: 17.62–49.56%; N = 9, n = 56), compared to 11.85% (95% CI: 2.43–21.28%; N = 9, n = 67) in the controls (p = 0.02), RR = 2.53 (95% CI: 1.18–5.42). These findings enhance the understanding of the health risks posed by 2,4-DTBP and provide a theoretical basis for environmental monitoring in public health. Full article
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