Live-Attenuated Bacterial Vaccines for the Prevention of Multiresistant Infections
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Attenuated/Inactivated/Live and Vectored Vaccines".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 4794
Special Issue Editors
Interests: antimicrobial resistance; animal models; bacterial pathogenesis; live bacterial vaccines; immune responses; mobile genetic elements; nosocomial pathogens; non-typhoidal Salmonella; plasmids; resistance genes; vaccine development
Interests: nosocomial pathogens; bacterial vaccines; antimicrobial resistance; host-pathogen interactions; immune response
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bacterial infections remain a major cause of mortality, with antimicrobial resistance being a contributing factor. At present, we are observing the continuous emergence of human infections caused by multidrug-resistant (MDR) bacteria. As a consequence, existing antibiotics have become less effective. Along with the increasing complexity in the development of new compounds, the effective treatment of bacterial infections is being seriously compromised. In order to address the impact of antimicrobial resistance, a multi-pronged approach will be needed, with priority given to accelerating the research and development of preventive vaccines. Whole-cell vaccines that comprise weakened versions of a bacterial pathogen are a promising strategy considering that they are able to elicit strong, effective and durable immune responses.
This Special Issue aims to provide advances in vaccines against both Gram-positive and Gram-negative pathogens, with the focus on those bacteria in which antimicrobial resistance/MDR is becoming increasingly common. Research topics may include (i) novel strategies for attenuating bacteria and/or the rational construction of live-attenuated strains, (ii) routes for safer administration and toxicity evaluation, (iii) vaccination-induced immune responses, and (iv) vaccine efficacy in relevant murine models of infection. Research papers, short communications, and reviews related to these topics are welcome for this Special Issue.
Dr. Patricia García
Dr. Miriam Moscoso
Guest Editors
Manuscript Submission Information
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Keywords
- antimicrobial resistance
- animal models
- bacterial attenuation strategies
- immune responses
- infectious diseases
- live bacterial vaccines
- protective efficacy
- vaccine development
- vaccine safety
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