African Swine Fever Virus (ASFV): Immunity and Vaccine Development
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 12446
Special Issue Editor
Special Issue Information
Dear Colleagues,
African swine fever virus (ASFV) is a causative agent of highly contagious and acute viral hemorrhagic disease; African swine fever (ASF) in domestic swine and wild boars is associated with significantly high mortality. ASFV is the only member of the family Asfaviridae, genus Asfivirus. It is a large, enveloped, and double-stranded DNA (dsDNA) virus that contains a linear DNA genome of 170 to 190 kb with more than 150 open reading frames (ORFs). Unfortunately, since its first description in Kenya in 1921, no commercial vaccines or approved anti-ASFV drugs are currently available. Therefore, the virus is spreading in Africa, Europe, and Asia, especially in China, with devastating social–economic consequences for the development of the swine industry and domestic food security. The unavailability of an applicable ASF vaccine is partly due to the complex nature of the virus, which encodes several proteins associated with immune evasion. Moreover, the incomplete understanding of immune protection determinants of ASFV hampers rational vaccine design. However, scientists work tirelessly to develop promising ASF vaccines, especially live attenuated and DNA vaccines.
This Special Issue of Vaccines aims to contribute to the current knowledge regarding immune evasion mechanisms used by the virus to establish an infection and approaches to vaccine development that are likely to benefit hosts upon subsequent natural infection. Original research articles, review articles, as well as short communications are invited.
Dr. Kiramage Chathuranga
Guest Editor
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Keywords
- African Swine Fever virus
- ASFV
- immune evasion
- vaccines
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