Nanoparticle Formulated Vaccines: Opportunities and Challenges

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1662

Special Issue Editors


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Guest Editor
Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA
Interests: immunology; mitochondria research

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Guest Editor
Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Interests: immunology; hematology

Special Issue Information

Dear Colleagues,

Post-COVID-19, there has been an explosion of interest in nanoparticulate-based vaccine technologies for immunization. The multidisciplinary nature of the development process for nanoparticulate systems for vaccines is challenging due to their intrinsic complexity. We are glad to announce this Special Issue, "Nanoparticle Formulated Vaccines: Opportunities and Challenges", of the journal Vaccines. This Special Issue covers recent advances in the design of efficient nanoparticulate vaccines against emergent infectious pathogens. This Special Issue will encompass vaccine preparation along with the merits and demerits of various nanoparticulate vaccine formulations in the field of vaccine technology. We hope this Special Issue will be able to address key areas of future research as well as highlighting current emerging technologies in the preclinical and clinical development of safe and effective vaccines. We will collect articles from top researchers describing new approaches or new cutting-edge developments in the field of nanoparticulate formulations of vaccines against infectious diseases. We welcome the submission of manuscripts for this issue.

Dr. Edmund Carvalho
Dr. Amrita Sarkar
Guest Editors

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Keywords

  • nanotherapy
  • vaccine development
  • immunology

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Published Papers (1 paper)

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Research

14 pages, 2037 KiB  
Article
Intranasal Vaccination with Recombinant TLR2-Active Outer Membrane Vesicles Containing Sequential M2e Epitopes Protects against Lethal Influenza a Challenge
by Nisha Kannan, Annette Choi, Mariela A. Rivera De Jesus, Peter Male Wei, Julie Marie Sahler, Stephanie Marie Curley, Avery August, Matthew P. DeLisa, Gary R. Whittaker and David Putnam
Vaccines 2024, 12(7), 724; https://doi.org/10.3390/vaccines12070724 - 29 Jun 2024
Viewed by 1328
Abstract
Influenza is a highly contagious respiratory disease, resulting in an estimated 3 to 5 million cases of severe illness annually. While most influenza vaccines are administered parenterally via injection, one shortcoming is that they do not generate a strong immune response at the [...] Read more.
Influenza is a highly contagious respiratory disease, resulting in an estimated 3 to 5 million cases of severe illness annually. While most influenza vaccines are administered parenterally via injection, one shortcoming is that they do not generate a strong immune response at the site of infection, which can become important in a pandemic. Intranasal vaccines can generate both local and systemic protective immune responses, can reduce costs, and enhance ease of administration. Previous studies showed that parenterally administered outer membrane vesicles (OMVs) that carry sequences of the M2e protein (OMV-M2e) protect against influenza A/PR8 challenge in mice and ferrets. In the current study, we measured the effectiveness of the intranasal route of the OMV-M2e vaccine against the influenza A/PR8 strain in mice. We observed high anti-M2e IgG and IgA titers post-challenge in mice vaccinated intranasally with OMV-M2e. In addition, we observed a Th1/Tc1 bias in the vaccinated mice, and an increased Th17/Tc17 response, both of which correlated with survival to A/PR8 challenge and significantly lower lung viral titers. We conclude that the intranasal-route administration of the OMV-M2e vaccine is a promising approach toward generating protection against influenza A as it leads to an increased proinflammatory immune response correlating with survival to viral challenge. Full article
(This article belongs to the Special Issue Nanoparticle Formulated Vaccines: Opportunities and Challenges)
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