Evaluation of Vaccine Efficacy, Safety and Immunogenicity against Influenza, RSV and COVID-19

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Efficacy and Safety".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 714

Special Issue Editor


E-Mail Website
Guest Editor
Janssen Prevention Center, 2333 CN Leiden, The Netherlands
Interests: COVID; vaccine; influenza; RSV
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Prophylactic vaccines against influenza and COVID-19 have been given to billions of individuals repeatedly and are effective for the prevention of severe disease. While the safety and efficacy of current influenza vaccines are established based on decades of use, new vaccine concepts to achieve higher efficacy, protection against infection and preferentially more universal protection have a yet-to-be-defined immunogenicity, safety and efficacy profile. Some of these new vaccine concepts have been used for the rapidly developed and licensed COVID-19 vaccines. These have shown to be safe, with a high efficacy against severe disease; however, safety concerns about rare cases of myocarditis, Guillain–Barré syndrome (GBS) and vaccine-induced immune thrombotic thrombocytopenia (VITT) became apparent shortly after vaccination, requiring further research to understand their etiology and long-term consequences. Recently, after decades of RSV, disease-targeting vaccines have been approved and are either based on more traditional subunits or mRNA technology. Understandings of long-term efficacy, immunogenicity and safety are limited and will add to our understanding of effective vaccines against viral respiratory infections.

In this Special Issue, we will collect original research on the immunogenicity, efficacy and safety evaluations of vaccines against influenza, RSV and SARS-CoV-2, preclinical and clinical research with candidate or licensed vaccines and long-term follow-up studies.

Dr. Roland Zahn
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • influenza
  • respiratory syncytial virus (RSV)
  • COVID-19
  • SARS-CoV-2
  • vaccines
  • immunogenicity
  • efficacy
  • safety
  • universal vaccine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 1956 KiB  
Article
Impact of Anti-SARS-CoV-2 Vaccination on Disease Severity and Clinical Outcomes of Individuals Hospitalized for COVID-19 Throughout Successive Pandemic Waves: Data from an Italian Reference Hospital
by Annalisa Mondi, Ilaria Mastrorosa, Assunta Navarra, Claudia Cimaglia, Carmela Pinnetti, Valentina Mazzotta, Alessandro Agresta, Angela Corpolongo, Alberto Zolezzi, Samir Al Moghazi, Laura Loiacono, Maria Grazia Bocci, Giulia Matusali, Alberto D’Annunzio, Paola Gallì, Fabrizio Maggi, Francesco Vairo, Enrico Girardi and Andrea Antinori
Vaccines 2024, 12(9), 1018; https://doi.org/10.3390/vaccines12091018 - 6 Sep 2024
Viewed by 541
Abstract
This is a retrospective observational study including all COVID-19 patients admitted at our Institute throughout three successive pandemic waves, from January 2021 to June 2023. The main in-hospital outcomes (clinical progression [CP], defined as admission to Intensive Care Unit [ICU]/death, and death within [...] Read more.
This is a retrospective observational study including all COVID-19 patients admitted at our Institute throughout three successive pandemic waves, from January 2021 to June 2023. The main in-hospital outcomes (clinical progression [CP], defined as admission to Intensive Care Unit [ICU]/death, and death within 28 days) were compared among participants unvaccinated (NV), fully vaccinated (FV), with one (FV&B1) and two (FV&B2) booster doses. Vaccinated participants were stratified into recently and waned FV/FV&B1/FV&B2, depending on the time elapsed from last dose (≤ and >120 days, respectively). There were 4488 participants: 2224 NV, 674 FV, 1207 FV&B1, and 383 FV&B2. Within 28 days, there were 604 ICU admissions, 396 deaths, and 737 CP. After adjusting for the main confounders, the risk of both in-hospital outcomes was reduced in vaccinated individuals, especially in those who received the booster dose (approximately by 36% for FV and >50% for FV&B1 and FV&B2 compared to NV). Similarly, after restricting the analysis to vaccinated participants only, we observed a risk reduction of approximately 40% for FV&B1 and 50% for FV&B2, compared to FV, regardless of the distance since the last dose. Our data confirm the vaccine’s effectiveness in preventing severe COVID-19 and support the efforts to increase the uptake of booster doses, mainly among older and frailer individuals, still at a greater risk of clinical progression. Full article
Show Figures

Figure 1

Back to TopTop