New Developments in Polio Vaccine
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Infectious Diseases".
Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 1414
Special Issue Editor
Interests: human poliovirus 1; oral poliomyelitis vaccine; poliomyelitis; enterovirus; heterologous immunity; immunity
Special Issue Information
Dear Colleagues,
The discovery of two vaccines against poliomyelitis—first the inactivated poliovirus vaccine (IPV) created by Jonas Salk, and soon after the live oral poliovirus vaccine (OPV) by Albert Sabin—was an enormous medical breakthrough of the mid-20th century. Their creation and use established a paradigm for other vaccines. Their evolution over the more than 60 years since their introduction is a perfect illustration of the need to continuously update medical products to match the changing epidemiological, economical, and societal landscape. OPV was so successful that in 1988, the World Health Assembly resolved to completely eradicate poliomyelitis by the year 2000. Even though the deadline was not met and polio eradication remains a moving target 35 years later, the Global Polio Eradication Initiative achieved tremendous progress. It also became clear that the current versions of IPV and OPV are not optimal for a post-eradication world. IPV is made from highly virulent virus strains and does not prevent virus transmission. OPV causes rare but serious adverse events and can trigger new outbreaks caused by a vaccine-derived virus. Therefore, finishing the eradication campaign and making its success irreversible requires the development and introduction of a new generation of polio vaccines. This Special Issue is devoted to these ongoing efforts.
Dr. Konstantin Chumakov
Guest Editor
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Keywords
- polio vaccines
- poliomyelitis
- inactivated poliovirus vaccine (IPV)
- live oral poliovirus vaccine (OPV)
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