Novel Adjuvants and Delivery Systems for Vaccines

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Adjuvants".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1014

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Sciences, Larkin University, Miami, FL 33169, USA
Interests: vaccines; drug development; adjuvants; nanoparticle; quorum sensing; antibiotics; pre-clinical research

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Guest Editor
Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, USA
Interests: vaccine delivery; microneedle based vaccine delivery; vaccine delivery using oral dissolving films
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Special Issue Information

Dear Colleagues,

Novel adjuvants and delivery systems for vaccines improve the quality of vaccine production by enhancing the immune response to a vaccine. Adjuvants can strengthen the immune system's response to the vaccine. Adjuvants have been traditionally used to increase the magnitude of the antibody response to a vaccine based on antibody titer or the ability to prevent infection and can guide the type of adaptive response to produce the most effective form of immunity. It is important to consider the construction of vaccine adjuvant delivery systems for both adjuvant activity and antigen delivery. In this Special Issue, we will explore prospective novel adjuvant approaches to modify innate and adaptive immune responses to ease the development of enhanced prophylactic or therapeutic vaccines. We welcome contributions to vaccine adjuvant advances, immune enhancement mechanisms, rational design, immunostimulatory molecules, emulsions, liposomes, virosomes, and polymers with functional molecules.

Dr. Christiane Chbib
Dr. Mohammad N. Uddin
Guest Editors

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Keywords

  • vaccines
  • drug development
  • adjuvants
  • nanoparticle

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Published Papers (1 paper)

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Review

20 pages, 849 KiB  
Review
Exploring the Biological Activities of Ionic Liquids and Their Potential to Develop Novel Vaccine Adjuvants
by Snehitha Akkineni, Mutasem Rawas-Qalaji, Samir A. Kouzi, Christiane Chbib and Mohammad N. Uddin
Vaccines 2025, 13(4), 365; https://doi.org/10.3390/vaccines13040365 - 28 Mar 2025
Viewed by 462
Abstract
Ionic liquids (ILs) are salts with poorly coordinated ions, allowing them to exist in a liquid phase below 100 °C or at room temperature. Therefore, they are best described as room temperature ionic liquids (RTILs). In ionic liquids, the presence of a delocalized [...] Read more.
Ionic liquids (ILs) are salts with poorly coordinated ions, allowing them to exist in a liquid phase below 100 °C or at room temperature. Therefore, they are best described as room temperature ionic liquids (RTILs). In ionic liquids, the presence of a delocalized charge in at least one ion, coupled with an organic component, inhibits the establishment of a stable solid crystal lattice. Due to their flexible properties and several distinctive characteristics, such as high ionic conductivity, high solvation power, thermal stability, low volatility, and recyclability, ILs have been extensively used in chemical industries. In addition to their various other applications, they also hold potential for drug formulation development. Ionic liquids can be used as solubility enhancers, permeability enhancers, stabilizers, targeted delivery inducers, stealth property providers, or bioavailability enhancers. Moreover, ILs hold significant potential in vaccine formulation. Many new vaccines are in the pipeline with different types of antigens; however, the existence of only a limited number of adjuvants hinder their potential use. Thus, developing new, highly effective, low-cost adjuvant preparations is a central interest among formulation scientists. With their unique properties and biological functions, ILs can be highly promising candidates for new types of vaccines. Full article
(This article belongs to the Special Issue Novel Adjuvants and Delivery Systems for Vaccines)
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