Respiratory Syncytial Virus (RSV) Vaccine

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Tropical and other Infectious Diseases".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1831

Special Issue Editor


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Guest Editor
Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD 20993, USA
Interests: vaccines; therapeutics; antibodies; virus; animal models
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Special Issue Information

Dear Colleagues,

Respiratory syncytial virus (RSV) remains a significant cause of respiratory infections, particularly in infants and the elderly. Despite decades of research, vaccine development has faced significant challenges. Recent advances in vaccine technology, including viral vectors, subunit vaccines with prefusion protein designs, and mRNA-based platforms, offer promising avenues for effective and safe RSV vaccination. This Special Issue aims to highlight current understanding and explore innovative strategies to develop RSV vaccines that ensure high protection rates and long-lasting efficacy across all age groups.

Dr. Surender Khurana
Guest Editor

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Keywords

  • respiratory syncytial virus (RSV)
  • RSV vaccine development
  • viral vector vaccines
  • subunit vaccines
  • prefusion protein design
  • mRNA vaccines
  • vaccine efficacy
  • immunization strategies

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Published Papers (1 paper)

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Review

36 pages, 3364 KiB  
Review
Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options
by Matteo Riccò, Bahaa Abu-Raya, Giancarlo Icardi, Vana Spoulou, David Greenberg, Oana Falup Pecurariu, Ivan Fan-Ngai Hung, Albert Osterhaus, Vittorio Sambri and Susanna Esposito
Vaccines 2024, 12(12), 1317; https://doi.org/10.3390/vaccines12121317 - 25 Nov 2024
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Abstract
Background/Objectives: Respiratory syncytial virus (RSV) is a leading cause of respiratory infections, particularly affecting young infants, older adults, and individuals with comorbidities. Methods: This document, developed as a consensus by an international group of experts affiliated with the World Association of Infectious [...] Read more.
Background/Objectives: Respiratory syncytial virus (RSV) is a leading cause of respiratory infections, particularly affecting young infants, older adults, and individuals with comorbidities. Methods: This document, developed as a consensus by an international group of experts affiliated with the World Association of Infectious Diseases and Immunological Disorders (WAidid), focuses on recent advancements in RSV prevention, highlighting the introduction of monoclonal antibodies (mAbs) and vaccines. Results: Historically, RSV treatment options were limited to supportive care and the monoclonal antibody palivizumab, which required multiple doses. Recent innovations have led to the development of long-acting mAbs, such as nirsevimab, which provide season-long protection with a single dose. Nirsevimab has shown high efficacy in preventing severe RSV-related lower respiratory tract infections (LRTIs) in infants, reducing hospitalizations and ICU admissions. Additionally, new vaccines, such as RSVpreF and RSVpreF3, target older adults and have demonstrated significant efficacy in preventing LRTIs in clinical trials. Maternal vaccination strategies also show promise in providing passive immunity to newborns, protecting them during the most vulnerable early months of life. This document further discusses the global burden of RSV, its economic impact, and the challenges of implementing these preventative strategies in different healthcare settings. Conclusions: The evidence supports the integration of both passive (mAbs) and active (vaccines) immunization approaches as effective tools to mitigate the public health impact of RSV. The combined use of these interventions could substantially reduce RSV-related morbidity and mortality across various age groups and populations, emphasizing the importance of widespread immunization efforts. Full article
(This article belongs to the Special Issue Respiratory Syncytial Virus (RSV) Vaccine)
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