Current Therapy in Theriogenology

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Reproduction and Obstetrics".

Deadline for manuscript submissions: 5 December 2024 | Viewed by 1510

Special Issue Editors


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Guest Editor
Research and Development Station for Cattle Breeding Dancu, 707252 Iaşi, Romania
Interests: dairy cow reproduction; economics of dairy cow reproduction; in vitro fertilization in dairy cows; bovine embryos; reproductive ultrasound in dairy cows; platelet rich-plasma in animal reproductive medicine; bovine mastitis

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Guest Editor
Department of Animal Reproduction, Veterinary Research Institute, National Research Centre, Tahrir St., Dokki 12622, Cairo, Egypt
Interests: animal reproduction; reproductive biotechnology; artificial insemination; molecular genetics; regenerative medicine

Special Issue Information

Dear Colleagues,

Current therapies in theriogenology are diverse, addressing a variety of issues such as breeding and conservation to address infertility and subfertility in animals. In farm animals, limitations on antibiotic use and the development of antimicrobial resistance require innovative therapies to alleviate the adverse effects of reproductive disorders. Regenerative medicine has also gained ground in veterinary medicine in recent years. The innovative therapies developed in veterinary reproductive medicine serve as a strong model for human reproductive medicine. Stem cell therapies and autologous platelet-rich plasma therapy are two of the therapies gaining more ground in veterinary reproductive medicine. The hidden aspect of infertility in animals is immunoinfertility, which occurs due to the blockage of receptor sites by antibodies formed against hormones, sperm, and ovum. Immunoinfertility in animals can be treated by giving females sexual rest and using various reproductive technologies such as artificial insemination, in vitro fertilization,  and embryo transfer. In dairy cows, current estrus and ovulation synchronization methods still need improvement. Future improvements require new reproductive strategies to minimize additional interventions and maintain acceptance by veterinarians. Thus, new therapies in animal reproductive medicine are currently a challenge to improving animal reproduction. This Special Issue aims to address the new challenges related to therapies and treatments in animal reproductive medicine.

Dr. Silviu-Ionuț Borș
Prof. Dr. Ahmed S. Abdoon
Guest Editors

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Keywords

  • animal reproduction
  • management
  • biotechnologies
  • therapy

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Published Papers (1 paper)

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Research

13 pages, 2597 KiB  
Article
Ameliorative Effect of Lycopene on Follicular Reserve Depletion, Oxidative Damage, Apoptosis Rate, and Hormonal Profile during Repeated Superovulations in Mice
by Shimaa I. Rakha, Ahmed I. Ateya, Fatmah A. Safhi and Ahmed M. Abdellatif
Vet. Sci. 2024, 11(9), 414; https://doi.org/10.3390/vetsci11090414 - 6 Sep 2024
Viewed by 763
Abstract
Superovulation is a crucial step in assisted reproductive technology that involves the administration of gonadotrophins. Repeated superovulations result in severe ovarian damage. The present study investigated the effect of in vivo administration of lycopene on ovarian damage induced by four successive cycles of [...] Read more.
Superovulation is a crucial step in assisted reproductive technology that involves the administration of gonadotrophins. Repeated superovulations result in severe ovarian damage. The present study investigated the effect of in vivo administration of lycopene on ovarian damage induced by four successive cycles of superovulation. Superovulated mice were simultaneously administered intraperitoneally with saline (R4) or 5 mg/kg lycopene (R4-Lyc). The evaluated parameters were the count of different types of follicles, expression of ovarian antioxidant- and apoptosis-related genes, and serum concentrations of estradiol, progesterone, and inhibin-B. Increased numbers of healthy follicles and a decreased count of atretic follicles were observed in mice of the R4-Lyc group compared to those of the R4 group. Moreover, significantly higher mRNA levels of Sod3, Cat, and Nrf2 and lower mRNA levels of Keap1, Tnf, Nfkb, and Casp3, together with decreased H2O2 concentrations and increased total antioxidant capacity, were detected in the ovaries of lycopene-treated mice. Regarding serum reproductive hormones, elevated concentrations of estradiol, progesterone, and inhibin-B were evident in lycopene-administered mice. The present study reports a significant role of lycopene in alleviating the ovarian damage induced by multiple hormonal superstimulations, which could help to improve the outcomes of in vitro embryo production. Full article
(This article belongs to the Special Issue Current Therapy in Theriogenology)
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