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Veterinary Sciences
Special Issues
Antimicrobial Compounds as Potential Veterinary Drugs and Their Effectiveness Assessment
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Antimicrobial Compounds as Potential Veterinary Drugs and Their Effectiveness Assessment

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Physiology, Pharmacology, and Toxicology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1899

Special Issue Editors

Prof. Dr. Fei Xu

E-Mail Website
Guest Editor
National Feed Drug Reference Laboratories, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Interests: dairy mastitis; bacterial infection; antimicrobial compounds; safety and efficacy evaluation
Dr. Xiaoye Liu

E-Mail Website
Guest Editor
Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, No. 7 Beinong Road, Changping, Beijing 102206, China
Interests: resistant bacteria; host-acting antimicrobial compounds; cytosolic bacteria, antibiotic tolerance; host-bacteria interaction

Special Issue Information

Dear Colleagues,

The management of bacterial diseases originating from animals primarily relies on comprehensive etiological investigations and the judicious application of effective antimicrobial agents. The widespread epidemic of drug-resistant bacteria originating from animals poses a significant threat to animal health and impedes the advancement of antimicrobial pharmaceuticals. Currently, the livestock and poultry industry is currently at a pivotal juncture regarding policy responses aimed at reducing and replacing antibiotics. Research into alternative therapeutic options—such as bacteriophages, immunomodulators, or novel compounds derived from natural sources—has gained momentum in recent years as scientists seek innovative solutions to this pressing issue. In recent years, some substances with antimicrobial properties have been selected and reported, but their complex mechanisms of action and multi-target pathways are still relatively unclear, and their antimicrobial effects have lacked systematic assessment. Therefore, the purpose of this Special Issue is to share different options for managing animal infectious diseases effectively while highlighting potential antimicrobial compounds that could serve as alternatives or adjuncts in combating resistant bacteria.

Topics of this special tissue interest include:

  • The discovery and development of antimicrobial compounds;
  • Novel antibacterial targets in animal infectious diseases;
  • Pathogenic and drug resistance mechanisms of animal-derived drug-resistant bacteria;
  • Natural products combating resistant bacteria;
  • Efficacy assessment of potential antimicrobial compounds.

Prof. Dr. Fei Xu
Dr. Xiaoye Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial compounds
  • MDR bacteria
  • antibacterial targets
  • multi-target therapeutic strategies
  • plant-derived products

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Published Papers (2 papers)

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Research

21 pages, 18953 KiB  
Article
Cinnamaldehyde Alleviates Salmonellosis in Chicks by Regulating Gut Health
by Lizi Yin, Luxin Li, Xue Lv, Fengsheng Sun, Yuyun Dai, Yingzi Guo, Shihao Peng, Chenyu Ye, Xiaoxia Liang, Changliang He, Gang Shu and Ping Ouyang
Vet. Sci. 2025, 12(3), 237; https://doi.org/10.3390/vetsci12030237 - 3 Mar 2025
Viewed by 668
Abstract
Due to the high mortality rate in chicks caused by pullorum disease (PD) and the drawbacks of antibiotic resistance, the poultry industry is increasingly interested in using natural herbal antimicrobial agents as alternatives, with cinnamaldehyde (CA) being a focus due to its multitarget [...] Read more.
Due to the high mortality rate in chicks caused by pullorum disease (PD) and the drawbacks of antibiotic resistance, the poultry industry is increasingly interested in using natural herbal antimicrobial agents as alternatives, with cinnamaldehyde (CA) being a focus due to its multitarget and synergistic effects. This study aimed to evaluate the effects of oral administration of CA on restoring intestinal physical integrity, intestinal microbial barrier, and intestinal metabolism in a laboratory model of Salmonella pullorum (S. pullorum) infection in chicks. Thirty-six chicks were divided into six groups. The S.P and CA groups were infected with 5 × 108 CFU/mL, 0.5 mL S. pullorum, while the CON group received an equal-volume saline injection. The CA group was treated with 100 mg/kg CA, and the others received phosphate buffer saline (PBS). Samples were collected 24 h after the last treatment. Intestinal physical integrity was assessed by H&E staining, and ELISA was used to measure inflammatory factors. In situ hybridization (ISH) and RT-qPCR were used to measure the expression of tight-junction protein mRNA. The microbiota was analyzed by 16S rRNA gene sequencing of the ileal contents, and metabolite analysis was performed on the intestinal contents. After CA treatment, the expression of IL-1β and TNF-α was reduced, and IL-10 was increased (p < 0.05). H&E staining showed that the intestinal structure was partially restored after treatment. ISH results showed that the fluorescence intensity indicating gene expression status was low in the S.P group and high in the CA group, indicating reduced intestinal permeability. RT-qPCR showed that CA up-regulated the mRNA expression of tight-junction proteins (claudin-1, occludin-1, and zo-1, p < 0.05). The 16S rRNA gene sequence analysis showed that Salmonella was significantly enriched in the S.P group (LDA score > 2.0, p < 0.05), while specific genera were significantly more abundant in the treated groups. Untargeted sequencing of intestinal contents showed that key metabolites (butyrate, alanine, glutamate, cholesterol, and propionate) in the CA group were significantly changed compared with the S.P group (p < 0.05). CA treatment was the most effective method for reducing PD intestinal colonization and maintaining better intestinal homeostasis, possibly by regulating intestinal microbiota and metabolic functions. Full article
(This article belongs to the Special Issue Antimicrobial Compounds as Potential Veterinary Drugs and Their Effectiveness Assessment)
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19 pages, 13618 KiB  
Article
Network Pharmacology and Molecular Docking: Exploring the Mechanism of Peppermint in Mastitis Prevention and Treatment in Dairy Cows
by Xinyu Wang, Jiaxin Lai, Fei Xu and Mingchun Liu
Vet. Sci. 2025, 12(2), 129; https://doi.org/10.3390/vetsci12020129 - 5 Feb 2025
Cited by 1 | Viewed by 949
Abstract
In order to elucidate the active ingredients, potential targets, and mechanisms of action of peppermint in treating bovine mastitis, this study utilized network pharmacology analysis and molecular docking to conduct an exploratory, prospective investigation. Using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, [...] Read more.
In order to elucidate the active ingredients, potential targets, and mechanisms of action of peppermint in treating bovine mastitis, this study utilized network pharmacology analysis and molecular docking to conduct an exploratory, prospective investigation. Using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, all compounds and targets of peppermint were retrieved. After removing duplicates, a total of 133 compounds and 272 targets were obtained. Targets were then standardized to gene names using the UniProt database to construct a drug–component-target network. A total of 183 disease targets related to bovine mastitis were retrieved from the GeneCards database. We obtained 28 cross targets of peppermint targets and bovine mastitis targets, and constructed a protein–protein interaction (PPI) network using the STRING database. A visual network was built using Cytoscape 3.10.0 software, and seven core targets were analyzed and obtained. GO and KEGG pathway enrichment analysis was performed using the Metascape database. Molecular docking was conducted using AutoDockTools–1.5.6 software on some small–molecule compounds and the seven targets to evaluate the stability of binding between peppermint and core targets. Apigenin, luteolin, and ursolic acid are the three main components in peppermint. Core targets (TNF, IL–6, STAT–3, IL–1β, FGF–2, IFNG, and ESR–1) were selected based on the PPI network. The enrichment analysis suggested that the major signaling pathways in network pharmacology may include AGEs–RAGE, IL–17, NF–κB, TLRs, HIF–1, TGF–β, PI3K–Akt, and MAPK. The molecular docking results showed that one of the main components of mint, ursolic acid, exhibited good binding activity with all core targets of bovine mastitis. Other constituents also produced favorable binding with some core targets. This study elucidates the mechanisms of mint in treating bovine mastitis, providing data to support the potential development of new therapies for bovine mastitis using mint and its constituents. Full article
(This article belongs to the Special Issue Antimicrobial Compounds as Potential Veterinary Drugs and Their Effectiveness Assessment)
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