Emerging Controversies and Advances in Neurovirology

Dear Colleagues,

Neurovirology is rapidly evolving, driven by novel discoveries and complex new challenges. Persistent viral infections are increasingly recognized for their potential roles in chronic neurological disorders, yet causal relationships and mechanisms remain active areas of debate. Recent events, such as the neurological sequelae of SARS-CoV-2 infection, have further highlighted the intricate interplay between viral pathogens and the nervous system, sparking urgent questions about viral invasion, immune responses, and long-term outcomes.

Innovative therapeutic strategies, including the use of oncolytic viruses for brain tumors, and novel research models such as neural organoids, are pushing the boundaries of the field, while simultaneously raising important ethical, safety, and regulatory concerns. In parallel, expanding knowledge about viral latency, neuroimmune interactions, and zoonotic threats underscores the need for interdisciplinary approaches and new frameworks for understanding virus–host dynamics within the central nervous system.

This Special Issue seeks to showcase cutting-edge research, comprehensive reviews, and thought-provoking perspectives that explore both established and emerging themes in neurovirology. Contributions addressing basic mechanisms, clinical implications, novel methodologies, therapeutic innovations, or ethical considerations are all welcome. By gathering a broad spectrum of insights, we aim to foster dialogue, inspire innovation, and highlight the pivotal role of viruses in shaping nervous system health and disease.

Dr. Karolina Akinosoglou
Guest Editor

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