Viral Genetic Variability and Its Role in Assessing Infectious Diseases

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".

Deadline for manuscript submissions: 6 May 2026 | Viewed by 958

Special Issue Editors

Special Issue Information

Dear Colleagues,

This Special Issue, 'Viral Genetic Variability and Its Role in Assessing Infectious Diseases', will explore the critical role of viral genetic diversity in the emergence, evolution, and spread of infectious diseases. This Special Issue will highlight the mechanisms driving viral mutations, recombination, and host adaptation, as well as their implications for host immune evasion and virus pathogenicity and transmission dynamics. By integrating cutting-edge genomic technologies, such as next-generation sequencing and bioinformatics, this Special Issue will provide insights into the genetic basis behind viral outbreaks and inform strategies for surveillance and prevention. We welcome contributions from geneticists, virologists, epidemiologists, and computational biologists, to advance our understanding of viral diversity and its impact on global health.

Dr. Fabio Scarpa
Guest Editor

Dr. Francesco Branda
Guest Editor Assistant

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Keywords

  • viral genetic diversity
  • infectious diseases
  • viral evolution
  • host adaptation
  • next-generation sequencing
  • pathogenicity
  • immune evasion
  • viral surveillance
  • bioinformatics
  • genetic variability
  • phylogeny
  • phylodynamics

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Published Papers (1 paper)

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Research

16 pages, 2598 KB  
Article
Genetic Diversity and Molecular Analysis of Human Parainfluenza Virus Type 3 in Saint Petersburg (Russia) in 2017–2023: Emergence of a New Phylogenetic Cluster
by Oula Mansour, Artem V. Fadeev, Alexander A. Perederiy, Marina I. Zadirienko, Daria M. Danilenko, Dmitry A. Lioznov and Andrey B. Komissarov
Viruses 2025, 17(9), 1197; https://doi.org/10.3390/v17091197 - 30 Aug 2025
Viewed by 669
Abstract
Human parainfluenza viruses 3 (hPIV3) are important pathogens, responsible for acute respiratory tract diseases, especially in young children. Information on hPIV3 circulation and their diversity pattern in Russia is limited. The aim of this study was to perform a molecular and genetic characterization [...] Read more.
Human parainfluenza viruses 3 (hPIV3) are important pathogens, responsible for acute respiratory tract diseases, especially in young children. Information on hPIV3 circulation and their diversity pattern in Russia is limited. The aim of this study was to perform a molecular and genetic characterization of hPIV3 circulating in Saint Petersburg, Russia. From October 2017 to September 2023, 14,704 swabs were screened using real-time reverse transcription-PCR. A phylogenetic analysis of the complete hemagglutinin–neuraminidase (HN) gene was performed. Out of 1334 positive hPIV cases, hPIV3 was the most common subtype. Phylogenetic analysis of the studied and previously published HN sequences revealed four distinct genetic clusters, A, B, C, and D, with Cluster D being first delineated in this study. In addition, two newly subdivided genetic lineages, C5a and C5b, were documented. Phylogenetic analysis revealed that the analyzed Russian strains grouped into Cluster C and D; further subclusters C5a, C5b, C3b, C3e, and C3a. While three strains were classified within cluster D, the majority of isolates fell within subcluster C3a, followed by C5b. Taken together, these findings demonstrate the co-circulation of hPIV3 strains during the study period. This is the first study that describes the genetic and molecular aspects of hPIV3 circulating in Russia. Moreover, our results provide an up-to-date hPIV3 phylogenetic analysis. Full article
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