Animal Papillomaviruses Research

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1817

Special Issue Editor


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Guest Editor
College of Medicine, Penn State College of Medicine, Hershey, PA, USA
Interests: rabbits; virion; cottontail rabbit papillomavirus; epitopes; antibodies; papillomavirus infections; human papillomavirus 16; capsid; human papillomavirus 11; monoclonal antibodies; papilloma viruses

Special Issue Information

Dear Colleagues,

Recently, animal papillomaviruses have become a topic of great interest, especially in academic and business circles. Understanding these viruses is important for improving animal health and finding new avenues for treatment. It is worth noting that animal papillomaviruses are different from human papillomaviruses and have the potential to cause a range of clinical manifestations in animals. These can include the emergence of warts and other skin lesions that are not harmful, as well as more serious conditions such as cancer. The pathogenesis of these viruses needs to be studied further to develop effective treatment strategies.

Studies have shown that there are many different animal papillomaviruses that can affect a wide variety of animals. These viruses have been found in birds, reptiles, amphibians, fish and mammals, and the search continues in other species and genera. They are typically spread through direct contact with infected animals or through contaminated surfaces. It is important to note that some species of animals are more susceptible to these viruses than others. For example, certain breeds of dogs are more prone to developing papillomavirus-associated cancers than others.

Studies of animal papillomavirus have establish many unique “firsts” in the papillomavirus research arena, including the following: (i) the first mammalian oncogenic virus described and experimental evidence of species restriction (Shope papilloma virus); (ii) the first papillomavirus genetically sequenced (bovine papillomavirus); (iii) the first identification of viral oncogenes and transforming genes such as E5, E6 and E7 (bovine papillomavirus); (iv) clear evidence of natural recombination between two virus types (dolphin papillomavirus); (v) the first naturally occurring hybrid papillomavirus/polyomavirus (bandicoot papillomavirus); and (vi) the initial validation of virus-like particle (VLP) papillomavirus vaccines (rabbit, canine and bovine papillomaviruses).

In conclusion, animal papillomaviruses are an important area of study that require further research. A better understanding of these viruses will lead to improved animal health and welfare, and may also have implications for human health. It is important to continue studying these viruses to ensure that they do not pose a threat to animal populations or human health.

This Special Issue is dedicated to the identification of novel or previously known papillomaviruses linked to diverse lesions in all species of animals. We cordially welcome submissions of both original research and review manuscripts that encompass all aspects related to papillomavirus infection, diagnosis and co-infection, as well as those that delve into the mechanistic interactions between co-infecting pathogens.

Prof. Dr. Neil Christensen
Guest Editor

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Published Papers (2 papers)

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12 pages, 3164 KiB  
Article
Canis Familiaris Papillomavirus Type 26: A Novel Papillomavirus of Dogs and the First Canine Papillomavirus within the Omegapapillomavirus Genus
by John S. Munday, Sarah D. Bond, Susan Piripi, Susannah J. Soulsby and Matthew A. Knox
Viruses 2024, 16(4), 595; https://doi.org/10.3390/v16040595 - 12 Apr 2024
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Abstract
Domestic dogs are currently recognized as being infected by 25 different canine papillomavirus (CPV) types classified into three genera. A short sequence from a novel CPV type was amplified, along with CPV1, from a papilloma (wart) from the mouth of a dog. The [...] Read more.
Domestic dogs are currently recognized as being infected by 25 different canine papillomavirus (CPV) types classified into three genera. A short sequence from a novel CPV type was amplified, along with CPV1, from a papilloma (wart) from the mouth of a dog. The entire 7499 bp genome was amplified, and CPV26 contained putative coding regions that were predicted to produce four early proteins and two late ones. The ORF L1 showed less than 62% similarity for all previously sequenced CPV types but over 69% similarity to multiple Omegapapillomavirus types from a variety of Caniform species including the giant panda, Weddel seal, and polar bear. Phylogenetic analysis confirmed CPV26 clusters within the Omegapapillomavirus genus. Specific primers were used to investigate the presence of CPV26 DNA within a series of 37 canine proliferative lesions. CPV26 DNA was amplified from one lesion, a cutaneous papilloma that also contained CPV6. This is the first time a PV type within the Omegapapillomavirus genus has been detected in a non-domestic species and this provides evidence that the omegapapillomaviruses infected a common ancestor of, and then co-evolved with, the Caniform species. Whether CPV26 causes disease is uncertain, but the absence of an E7 protein may suggest low pathogenicity. Full article
(This article belongs to the Special Issue Animal Papillomaviruses Research)
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13 pages, 2989 KiB  
Brief Report
Interspecies Papillomavirus Type Infection and a Novel Papillomavirus Type in Red Ruffed Lemurs (Varecia rubra)
by Elise N. Paietta, Simona Kraberger, Melanie Regney, Joy M. Custer, Erin Ehmke, Anne D. Yoder and Arvind Varsani
Viruses 2024, 16(1), 37; https://doi.org/10.3390/v16010037 - 25 Dec 2023
Cited by 1 | Viewed by 982
Abstract
The Papillomaviridae are a family of vertebrate-infecting viruses of oncogenic potential generally thought to be host species- and tissue-specific. Despite their phylogenetic relatedness to humans, there is a scarcity of data on papillomaviruses (PVs) in speciose non-human primate lineages, particularly the lemuriform primates. [...] Read more.
The Papillomaviridae are a family of vertebrate-infecting viruses of oncogenic potential generally thought to be host species- and tissue-specific. Despite their phylogenetic relatedness to humans, there is a scarcity of data on papillomaviruses (PVs) in speciose non-human primate lineages, particularly the lemuriform primates. Varecia variegata (black-and-white ruffed lemurs) and Varecia rubra (red ruffed lemurs), two closely related species comprising the Varecia genus, are critically endangered with large global captive populations. Varecia variegata papillomavirus (VavPV) types −1 and −2, the first PVs in lemurs with a fully identified genome, were previously characterized from captive V. variegata saliva. To build upon this discovery, saliva samples were collected from captive V. rubra with the following aims: (1) to identify PVs shared between V. variegata and V. rubra and (2) to characterize novel PVs in V. rubra to better understand PV diversity in the lemuriform primates. Three complete PV genomes were determined from V. rubra samples. Two of these PV genomes share 98% L1 nucleotide identity with VavPV2, denoting interspecies infection of V. rubra by VavPV2. This work represents the first reported case of interspecies PV infection amongst the strepsirrhine primates. The third PV genome shares <68% L1 nucleotide identity with that of all PVs. Thus, it represents a new PV species and has been named Varecia rubra papillomavirus 1 (VarPV1). VavPV1, VavPV2, and VarPV1 form a new clade within the Papillomaviridae family, likely representing a novel genus. Future work diversifying sample collection (i.e., lemur host species from multiple genera, sample type, geographic location, and wild populations) is likely to uncover a world of diverse lemur PVs. Full article
(This article belongs to the Special Issue Animal Papillomaviruses Research)
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