Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options

Dear Colleagues,

Antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are the mainstay of treatment and prevention measures for HIV/AIDS pandemic control. The expanded global access to ART has resulted in an exponential rise in acquired and transmitted HIV drug resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs), threatening the clinical benefits of ART in long-term HIV management. Recent ART and PrEP options have shifted to integrase strand transfer (INSTI)-based regimens that show higher potency and genetic barriers to resistance. The simplification to two-drug regimens and long-acting injectable formulations may result in a newly emergent resistance. This Special Issue welcomes articles that describe the potency, durability and pharmacokinetics of newer ART and PrEP options for virological suppression and as barriers to resistance.

Characterization of the genotypic, phenotypic, and phylogenetic features of emergent resistance species may provide a more nuanced understanding of the virologic potency and pharmacofragility of streamlined and long-acting regimens.

Prof. Dr. Bluma G. Brenner
Guest Editor

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