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Viruses
Special Issues
Protein and Nucleic Acid Modifications in Response to Virus Infection
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Protein and Nucleic Acid Modifications in Response to Virus Infection

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 5945

Special Issue Editor

Dr. Matloob Husain

E-Mail Website
Guest Editor
Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand
Interests: molecular virology; influenza virus; viral pathogenesis; virus–host interactions; innate antiviral response; post-translational protein modifications; protein trafficking; acetylation; HDACs; HATs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Viruses utilise and exploit the host cell machinery to multiply. The inter- and intra-molecular interactions which play a critical role in virus–host interactions are known to be influenced by the complexity of the host proteome and transcriptome. Nevertheless, the layers of such complexity continue to unravel with the invention and application of new technologies. One of the phenomena which impacts this complexity is the reversible and irreversible modifications of both host and viral proteins as well as nucleic acids during infection. A plethora of such modifications, e.g., phosphorylation, glycosylation, acylation, methylation, and acetylation, etc., is known; many of them are dynamic and occur or change in response to virus infection. Many of these modifications have been known for some time, whereas many have been discovered recently. Nevertheless, the magnitude of these modifications in response to virus infection continues to unravel and is detrimental for comprehensive understanding of virus–host interactions. This Special Issue of Viruses invites articles reporting the latest research developments in this discipline of virology research.

Dr. Matloob Husain
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • host and viral proteome
  • omics
  • protein modifications
  • DNA and RNA modifications
  • acetylation
  • methylation

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Published Papers (1 paper)

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Research

22 pages, 47268 KiB  
Article
Acetylation, Methylation and Allysine Modification Profile of Viral and Host Proteins during Influenza A Virus Infection
by Farjana Ahmed, Torsten Kleffmann and Matloob Husain
Viruses 2021, 13(7), 1415; https://doi.org/10.3390/v13071415 - 20 Jul 2021
Cited by 12 | Viewed by 5075
Abstract
Protein modifications dynamically occur and regulate biological processes in all organisms. Towards understanding the significance of protein modifications in influenza virus infection, we performed a global mass spectrometry screen followed by bioinformatics analyses of acetylation, methylation and allysine modification in human lung epithelial [...] Read more.
Protein modifications dynamically occur and regulate biological processes in all organisms. Towards understanding the significance of protein modifications in influenza virus infection, we performed a global mass spectrometry screen followed by bioinformatics analyses of acetylation, methylation and allysine modification in human lung epithelial cells in response to influenza A virus infection. We discovered 8 out of 10 major viral proteins and 245 out of 2280 host proteins detected to be differentially modified by three modifications in infected cells. Some of the identified proteins were modified on multiple amino acids residues and by more than one modification; the latter occurred either on different or same residues. Most of the modified residues in viral proteins were conserved across >40 subtypes of influenza A virus, and influenza B or C viruses and located on the protein surface. Importantly, many of those residues have already been determined to be critical for the influenza A virus. Similarly, many modified residues in host proteins were conserved across influenza A virus hosts like humans, birds, and pigs. Finally, host proteins undergoing the three modifications clustered in common functional networks of metabolic, cytoskeletal, and RNA processes, all of which are known to be exploited by the influenza A virus. Full article
(This article belongs to the Special Issue Protein and Nucleic Acid Modifications in Response to Virus Infection)
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