Host Cell-Virus Interaction, 4th Edition
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 14 March 2025 | Viewed by 765
Special Issue Editors
Interests: host cell-virus interaction; intracellular trafficking of virus; membrane trafficking; non-enveloped viruses; positive sense RNA viruses
Special Issues, Collections and Topics in MDPI journals
Interests: RNA virus; viral pathogenesis; host cell–virus interaction; RNAi; small RNA as therapeutics; targeted delivery; virus and cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Activation of immune responses is the key factor for host defense against any viral infections. Yet, viruses have also adapted several strategies to escape or suppress host resistance to make a proviral environment using the cellular machineries that represent the most important components of viral pathogenicity. As an obligate parasite, viruses are eventually reliant on the host cellular components for their replication via altering the cellular signal transduction pathways and immune evasion mechanisms, including escaping recognition from intracellular sensors, suppression of IFN-α/β production, NF-kappaB, dysregulation of inflammatory responses and inflammasome activation signals, RNA interference, modulation of autophagy and programmed cell-death mechanisms, and selection of genetic variants that escape from neutralizing antibodies.
Significant research on antivirals to combat viral infections is an extensive process, which requires multidisciplinary approaches. For any antiviral agents, such as synthetic drugs, chemical inhibitors, RNAi strategies of miRNAs or siRNAs, natural compounds, phytoconstituents, herbal or Ayurvedic formulations, and metallic nanoparticles, apparently there are two different strategies of antiviral drug discovery available, which are based on targeting the viral lifecycle and/or directing the host cellular factors. The modus operandi of antivirals characterization is fundamental for identification, prediction and understanding side-effects, drug interactions and the emergence of resistance, for increasing the spectrum of activity, and for improving antiviral efficacy.
For this Special Issue, we welcome original research papers, communications and review articles that contribute to an improved understanding of the molecular details of host cell–virus interaction through viral immune evasion and host defense mechanism during any viral infection. Furthermore, understanding the mechanism of action of host-centric and/or targeting viral lifecycle antivirals could further refine our understanding of virus–host interactions and the antiviral strategies for treatment and prophylaxis, which are essential to managing any active viral infections. Hence, we invite all researchers working in the field of viral lifecycle, pathogenesis, host responses and antiviral development to submit their research to this Special Issue to highlight recent advancements and further the discussion on host–virus interactions and prospective therapeutics.
Dr. Parikshit Bagchi
Dr. Anupam Mukherjee
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- virus
- viral proteins
- virus entry
- viral replication and pathogenesis
- virus assembly and egress
- intracellular trafficking of virus
- host cell
- cellular signaling
- interferon pathway
- inflammasome
- viral immune evasion
- immune response
- cell death
- apoptosis
- autophagy
- host-virus interaction
- anti-viral strategies
- direct acting antivirals
- broad-spectrum antiviral agents
- RNAi
- microRNAs
- neutralizing antibodies
- molecular mechanisms of antivirals
- molecular mechanisms of drug-resistance
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