Respiratory Syncytial Virus 2.0
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 32472
Special Issue Editors
Interests: influenza virus; respiratory syncytial virus; viral pathogenesis; monocytes; macrophages; lymphocytes
Special Issues, Collections and Topics in MDPI journals
Interests: respiratory syncytial virus; influenza virus; clinical trials; respiratory virus vaccines; RSV-related inflammation and immune responses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Respiratory syncytial virus (RSV) is a major cause of respiratory infections worldwide, with the most severe cases occurring in the very young and in elderly individuals. Infants and children having their first encounter with the virus are more likely to develop bronchiolitis and pneumonia, and even die. However, most deaths overall occur with infections of the elderly. In addition, immunocompromised individuals of any age are at greater risk of adverse outcomes.
RSV re-infection occurs throughout life, but subsequent infections are commonly less severe than the initial episode, as a result of the immune response that is established after exposure to the virus. However, the immune response is not able to prevent clinical re-infection even in the absence of RSV strain variation. This aspect makes it important to delineate as much as possible the immune response and correlates of protection, and it also suggests that RSV candidate vaccines that are being developed may not and perhaps should not be expected to prevent clinical re-infection. Such candidate vaccines should render a first infection in the young person less severe, as are subsequent infections after a natural first encounter in childhood. Such vaccines may also be expected to boost potentially waning immunity in the elderly, used at intervals to promote patient survival with the natural RSV infection.
The aim of this Special Issue of Viruses is to contribute to the current knowledge regarding innate and adaptive immunity to RSV, the mechanisms used by the virus to accomplish re-infection, the populations at risk and epidemiology of the infection, treatment approaches directed at RSV or designed to counteract the suppression of immune responses by RSV, and approaches to vaccine development that are likely to benefit the host upon subsequent natural challenge. Research articles, review articles, as well as short communications are invited. Reports of promising candidate RSV vaccines and reports of RSV co-infections (e.g., with SARS-CoV-2) are encouraged.
Submitted manuscripts should not have been published previously and should not be under consideration for publication elsewhere. All manuscripts undergo a single-blind peer-review process. Papers belonging to a Special Issue are published online in Viruses immediately after acceptance and are collected together on the Special Issue webpage. This means that there is no delay for authors who submit their work. Papers will appear shortly after acceptance, even if other papers in the Special Issue are still being processed. The Article Processing Charge for publication in this open-access journal, Viruses (IF 5.048), is CHF 2000 (Swiss Francs).
Dr. Norbert J. Roberts, Jr.
Dr. Leonard R. Krilov
Guest Editors
Manuscript Submission Information
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Keywords
- Respiratory syncytial virus
- RSV pathogenesis
- Innate immunity to RSV
- Adaptive immunity to RSV
- RSV re-infection
- RSV therapy
- RSV vaccines
- RSV epidemiology
- RSV co-infections
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Related Special Issue
- Respiratory Syncytial Virus in Viruses (5 articles)