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Viruses
Special Issues
Phage Cocktails: Promising Approaches Against Infections
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Phage Cocktails: Promising Approaches Against Infections

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Bacterial Viruses".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1620

Special Issue Editor

Prof. Dr. Jin Woo Jun

E-Mail Website
Guest Editor
Department of Aquaculture, Korea National University of Agriculture and Fisheries, Jeonju, Republic of Korea
Interests: bacteriophage; phage therapy; infectious diseases; general microbiology; molecular microbiology; genome sequencing; antibiotic resistance; zoonosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our efforts to find alternatives to antimicrobial agents have already begun due to the increase in antibiotic resistance and delay in developing novel antibiotics. Bacteriophages (phages for short) are proposed as a potential alternative to antibiotics because there is no solid scientific evidence that phages could impose a safety problem. Indeed, research on phage applications against infections has become accelerated because antibiotics have been overused covertly and overtly, increasing the risks of antibiotic resistance. Phage cocktails, a mixture of different phages, have been considered the best approach for successful phage therapy since they can maximize the potential usefulness of phage therapy. In this Special Issue, we intend to publish original and review articles describing the potential of phage cocktails as therapeutic and/or prophylactic products against bacterial infections that cause infectious diseases in a variety of fields, including human medicine, veterinary medicine, agriculture, the food industry, and public health. Particularly, articles showing the efficacy of phage therapy or/and prophylaxis by conducting in vivo animal experiments according to the ethics guidelines are welcome. In addition, we invite articles that suggest phage applications for zoonoses.

Prof. Dr. Jin Woo Jun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phage cocktail
  • phage therapy
  • prophylaxis
  • infectious diseases
  • veterinary medicine
  • agriculture
  • food industry
  • zoonoses

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Published Papers (2 papers)

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Research

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14 pages, 3078 KiB  
Article
Sxt1, Isolated from a Therapeutic Phage Cocktail, Is a Broader Host Range Relative of the Phage T3
by Polina Iarema, Oksana Kotovskaya, Mikhail Skutel, Alena Drobiazko, Andrei Moiseenko, Olga Sokolova, Alina Samitova, Dmitriy Korostin, Konstantin Severinov and Artem Isaev
Viruses 2024, 16(12), 1905; https://doi.org/10.3390/v16121905 - 11 Dec 2024
Viewed by 639
Abstract
Using Escherichia coli BW25113 as a host, we isolated a novel lytic phage from the commercial poly-specific therapeutic phage cocktail Sextaphage® (Microgen, Russia). We provide genetic and phenotypic characterization of the phage and describe its host range on the ECOR collection of [...] Read more.
Using Escherichia coli BW25113 as a host, we isolated a novel lytic phage from the commercial poly-specific therapeutic phage cocktail Sextaphage® (Microgen, Russia). We provide genetic and phenotypic characterization of the phage and describe its host range on the ECOR collection of reference E. coli strains. The phage, hereafter named Sxt1, is a close relative of classical coliphage T3 and belongs to the Teetrevirus genus, yet its internal virion proteins, forming an ejectosome, differ from those of T3. In addition, the Sxt1 lateral tail fiber (LTF) protein clusters with those of the phages from the Berlinvirus genus. A comparison of T7, T3, and Sxt1 LTFs reveals the presence of insertions leading to the elongation of Sxt1 tail fibers, which, together with the difference in the HRDRs (host range-determining regions), might explain the expanded host specificity for the Sxt1. Full article
(This article belongs to the Special Issue Phage Cocktails: Promising Approaches Against Infections)
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Review

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13 pages, 612 KiB  
Review
A Concise Overview of Studies on Successful Real-World Applications of Bacteriophages in Aquaculture
by Jin Woo Jun
Viruses 2024, 16(12), 1843; https://doi.org/10.3390/v16121843 - 28 Nov 2024
Viewed by 740
Abstract
Increasing antibiotic resistance poses an urgent global public health threat and a serious concern worldwide. Bacteriophage (phage) therapy has been identified as a promising alternative to antibiotics for treating bacterial diseases in both humans and animals. The excessive use of antibiotics in aquaculture [...] Read more.
Increasing antibiotic resistance poses an urgent global public health threat and a serious concern worldwide. Bacteriophage (phage) therapy has been identified as a promising alternative to antibiotics for treating bacterial diseases in both humans and animals. The excessive use of antibiotics in aquaculture is a major threat to sustainable aquaculture, promoting the spread of antibiotic resistance in the aquaculture environment and the contamination of aquaculture products with antibiotic residues. Consequently, interest in alternative approaches that reduce reliance on antibiotics has grown within the aquaculture sector. As a promising alternative, extensive phage research targeted at aquaculture has demonstrated the protective efficacy of phages against diseases in aquatic animals. Although numerous studies have employed in vitro models, research supported by in vivo experiments remains scarce. Without in vivo evidence, phage therapy cannot fulfill the requirements of aquaculturists. The first part of this review outlines the bacterial diseases severely affecting the health and survival of aquatic animals. The second part provides updates on phage applications for the therapy and prophylaxis of pathogenic bacterial infection in aquatic animals, including administration routes and key accomplishments. Therefore, this review provides insights into effective real-world phage biocontrol strategies that enable sustainable aquaculture. Full article
(This article belongs to the Special Issue Phage Cocktails: Promising Approaches Against Infections)
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