The Roles of EBV Infection in the Internal and External Environment of EBV-Related Tumors

Dear Colleagues,

Epstein-Barr virus (EBV) belongs to the γ subfamily of the family Herpesviridae. It has the property of phagocytosing B lymphocytes, and can establish latent infection in B lymphocytes and stimulate the proliferation and transformation of cells. The infection rate in the population is more than 90%. Although most EBV-infected individuals remain asymptomatic, EBV infection increases the risk of developing various malignancies. In 1997, the World Health Organization's International Agency for Research on Cancer (LARC) report classified EBV as being among carcinogens. EBV is associated with an increasing number of human tumors, including post-transplant lymphoproliferative disease (PTLD), Hodgkin's disease (HD), Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC) and approximately 10–15% of gastric cancers, etc. However, its role in these malignancies has not been fully elucidated. The effects of EBV on tumor cells and the tumor microenvironment at different stages of infection are obvious and worth exploring.

Dr. Xiaoming Lyu
Dr. Chi Man Tsang
Guest Editors

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