Radiation Therapy in Metastatic Soft Tissue Sarcoma: From Palliation to Ablation
Abstract
:Simple Summary
Abstract
1. Introduction
2. Current Management of Metastatic Soft Tissue Sarcoma
3. Role of Local Therapy in Metastatic Cancer
4. Role of Radiotherapy to Sites of Metastases
4.1. Pulmonary Metastasis
4.2. Spine
4.3. Brain
5. Role of Radiation Therapy to Primary Site in Metastatic Soft Tissue Sarcoma
6. Role of SBRT in Sarcoma for Pediatrics, Adolescents, and Young Adults
7. Role of Combined Radiotherapy and Immunotherapy in Metastatic Soft Tissue Sarcoma
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Study | Radiation Dose | Number of Patients | 24-Month LC (%) | 24-Month OS (%) |
---|---|---|---|---|
Frakulli et al., Italy [29] | 30–60 Gy/3–8fx | 24 | 85.9 | 66.4 |
Lindsay et al., Connecticut [30] | Mostly 50 Gy/10 fx, 50 Gy/5 fx | 44 | 95 | 82 |
Baumann et al., Penn [32,33] | 50 Gy/4–5 fx | 44 | 90 | 46 |
Dhakal et al., Rochester [34] | 50 Gy/5 fx | 15 | 88 | 50 |
Navarria et al., Italy [35] | 30 Gy/1 fx, 60 Gy/3 fx, 60 Gy/8 fx, 48 Gy/4 fx | 28 | 96.2 | 96.2 |
Mehta et al., UCLA [36] | 54 Gy/3 fx, 50 Gy/4 fx, 36 Gy/3 fx, 42 Gy/3 fx | 16 | 94 | NR |
Study | Treated Site | Number of Patients | Number of Treated Lesions | 12-Month LC (%) | 12-Month OS (%) |
---|---|---|---|---|---|
Folkert et al., MSKCC [39] | Spine | 88 | 120 | 87.9 | 60.6 |
Bishop et al., MDACC [41] | Spine | 48 | 66 | 81 | 67 |
Sim et al., Moffit [44] | Brain | 24 | 58 | 89 | 38 |
Flannery et al., Pittsburgh [45] | Brain | 21 | 60 | 88 | 60 |
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Shah, N.K.; Yegya-Raman, N.; Jones, J.A.; Shabason, J.E. Radiation Therapy in Metastatic Soft Tissue Sarcoma: From Palliation to Ablation. Cancers 2021, 13, 4775. https://doi.org/10.3390/cancers13194775
Shah NK, Yegya-Raman N, Jones JA, Shabason JE. Radiation Therapy in Metastatic Soft Tissue Sarcoma: From Palliation to Ablation. Cancers. 2021; 13(19):4775. https://doi.org/10.3390/cancers13194775
Chicago/Turabian StyleShah, Nishant K., Nikhil Yegya-Raman, Joshua A. Jones, and Jacob E. Shabason. 2021. "Radiation Therapy in Metastatic Soft Tissue Sarcoma: From Palliation to Ablation" Cancers 13, no. 19: 4775. https://doi.org/10.3390/cancers13194775