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Volume 57
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10.3390/medicina57060588
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Article

Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI

by
Aydin Rodi Tosu
1,
Muhsin Kalyoncuoglu
1,
Halil İbrahim Biter
1,
Sinem Cakal
1,
Murat Selcuk
2,
Tufan Çinar
2,*,
Erdal Belen
1 and
Mehmet Mustafa Can
1
1
Department of Cardiology, Haseki Training and Research Hospital, University of Health Sciences, 34130 Istanbul, Turkey
2
Department of Cardiology, Sultan II. Abdülhamid Han Training and Research Hospital, University of Health Sciences, 34668 Istanbul, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2021, 57(6), 588; https://doi.org/10.3390/medicina57060588
Submission received: 24 May 2021 / Accepted: 3 June 2021 / Published: 8 June 2021
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Abstract

Background and objectives: In this study, we aimed to evaluate whether the systemic immune-inflammation index (SII) has a prognostic value for major adverse cardiac events (MACEs), including stroke, re-hospitalization, and short-term all-cause mortality at 6 months, in aortic stenosis (AS) patients who underwent transcatheter aortic valve implantation (TAVI). Materials and Methods: A total of 120 patients who underwent TAVI due to severe AS were retrospectively included in our study. The main outcome of the study was MACEs and short-term all-cause mortality at 6 months. Results: The SII was found to be higher in TAVI patients who developed MACEs than in those who did not develop them. Multivariate Cox regression analysis revealed that the SII (HR: 1.002, 95%CI: 1.001–1.003, p < 0.01) was an independent predictor of MACEs in AS patients after TAVI. The optimal value of the SII for MACEs in AS patients following TAVI was >1.056 with 94% sensitivity and 96% specificity (AUC (the area under the curve): 0.960, p < 0.01). We noted that the AUC value of SII in predicting MACEs was significantly higher than the AUC value of the C-reactive protein (AUC: 0.960 vs. AUC: 0.714, respectively). Conclusions: This is the first study to show that high pre-procedural SII may have a predictive value for MACEs and short-term mortality in AS patients undergoing TAVI.
Keywords: SII; inflammation; major adverse cardiac events; mortality; TAVI SII; inflammation; major adverse cardiac events; mortality; TAVI

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MDPI and ACS Style

Tosu, A.R.; Kalyoncuoglu, M.; Biter, H.İ.; Cakal, S.; Selcuk, M.; Çinar, T.; Belen, E.; Can, M.M. Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI. Medicina 2021, 57, 588. https://doi.org/10.3390/medicina57060588

AMA Style

Tosu AR, Kalyoncuoglu M, Biter Hİ, Cakal S, Selcuk M, Çinar T, Belen E, Can MM. Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI. Medicina. 2021; 57(6):588. https://doi.org/10.3390/medicina57060588

Chicago/Turabian Style

Tosu, Aydin Rodi, Muhsin Kalyoncuoglu, Halil İbrahim Biter, Sinem Cakal, Murat Selcuk, Tufan Çinar, Erdal Belen, and Mehmet Mustafa Can. 2021. "Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI" Medicina 57, no. 6: 588. https://doi.org/10.3390/medicina57060588

APA Style

Tosu, A. R., Kalyoncuoglu, M., Biter, H. İ., Cakal, S., Selcuk, M., Çinar, T., Belen, E., & Can, M. M. (2021). Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI. Medicina, 57(6), 588. https://doi.org/10.3390/medicina57060588

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