Rehabilitation of the Completely Edentulous Mandible by All-on-Four Treatment Concept: A Retrospective Cohort Study with Up to 10 Years Follow-Up
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Protocol
2.2. Surgical Procedure
2.3. Prosthodontic Procedure
2.4. Follow-Up Visits and Outcomes
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016, 388, 1545–1602. [Google Scholar] [CrossRef] [Green Version]
- Fernández-Olarte, H.; Gómez-Delgado, A.; Gutiérrez-Quintero, J.G.; Rodríguez-Sáenz, Á.; Castro-Núñez, J. The Morpho-Functional Three-Dimensional Analysis for Zygomatic Implants: A Clinical Tool With Surgical Implications. J. Craniofac. Surg. 2021, 32, e254–e257. [Google Scholar] [CrossRef]
- Maló, P.; de Araújo Nobre, M.; Lopes, A.; Ferro, A.; Botto, J. The All-on-4 treatment concept for the rehabilitation of the completely edentulous mandible: A longitudinal study with 10 to 18 years of follow-up. Clin. Implant. Dent. Relat. Res. 2019, 21, 565–577. [Google Scholar] [CrossRef]
- Marrelli, M.; Pacifici, A.; Di Giorgio, G.; Cassetta, M.; Stefanelli, L.V.; Gargari, M.; Promenzio, L.; Annibali, S.; Cristalli, M.P.; Chiaravalloti, E.; et al. Diagnosis and treatment of a rare case of adenomatoid odontogenic tumor in a young patient affected by attenuated familial adenomatosis polyposis (aFAP): Case report and 5 year follow-up. Eur. Rev. Med. Pharmacol. Sci. 2014, 18, 265–269. [Google Scholar]
- Weinstein, R.; Agliardi, E.; Fabbro, M.D.; Romeo, D.; Francetti, L. Immediate rehabilitation of the extremely atrophic mandible with fixed full-prosthesis supported by four implants. Clin. Implant. Dent. Relat. Res. 2012, 14, 434–441. [Google Scholar] [CrossRef]
- Krekmanov, L.; Kahn, M.; Rangert, B.; Lindström, H. Tilting of posterior mandibular and maxillary implants for improved prosthesis support. Int. J. Oral Maxillofac. Implant. 2020, 15, 405–414. [Google Scholar]
- Cucchi, A.; Vignudelli, E.; Franco, S.; Ghensi, P.; Malchiodi, L.; Corinaldesi, G. Evaluation of crestal bone loss around straight and tilted implants in patients rehabilitated by immediate-loaded full-arch All-on-4 or All-on-6: A prospective study. Oral Implantol. 2019, 45, 434–443. [Google Scholar] [CrossRef]
- Maló, P.; Rangert, B.; Nobre, M. “All-on-Four” immediate-function concept with Branemark System implants for completely edentulous mandibles: A retrospective clinical study. Clin. Implant. Dent. Relat. Res. 2003, 5, 2–9. [Google Scholar] [CrossRef]
- Perniconi, B.; Coletti, D.; Aulino, P.; Costa, A.; Aprile, P.; Santacroce, L.; Chiaravalloti, E.; Coquelin, L.; Chevallier, N.; Teodori, L.; et al. Muscle acellular scaffold as a biomaterial: Effects on C2C12 cell differentiation and interaction with the murine host environment. Front. Physiol. 2014, 5, 354. [Google Scholar] [CrossRef] [Green Version]
- Brånemark, P.I.; Svensson, B.; van Steenberghe, D. Ten-year survival rates of fixed prostheses on four or six implants ad modum Brånemark in full edentulism. Clin. Oral Implant. Res. 1995, 6, 227–231. [Google Scholar] [CrossRef]
- Soto-Penaloza, D.; Zaragozí-Alonso, R.; Penarrocha-Diago, M.; Penarrocha-Diag, M. The all-on-four treatment concept: Systematic review. J. Clin. Exp. Dent. 2017, 9, e474–e488. [Google Scholar] [CrossRef] [Green Version]
- Bressan, E.; Ferroni, L.; Gardin, C.; Bellin, G.; Sbricoli, L.; Sivolella, S.; Brunello, G.; Schwartz-Arad, D.; Mijiritsky, E.; Penarrocha, M.; et al. Metal Nanoparticles Released from Dental Implant Surfaces: Potential Contribution to Chronic Inflammation and Peri-Implant Bone Loss. Materials 2019, 12, 2036. [Google Scholar] [CrossRef] [Green Version]
- Fusco, A.; Dicuonzo, G.; Dell’Atti, V.; Tatullo, M. Blockchain in Healthcare: Insights on COVID-19. Int. J. Environ. Res. Public Health 2020, 17, 7167. [Google Scholar] [CrossRef]
- Malò, P.; Rangert, B.; Dvarsater, L. Immediate function of Branemark implants in the esthetic zone: A retrospective clinical study with 6 months to 4 years of follow-up. Clin. Implant. Dent. Relat. Res. 2000, 2, 138–146. [Google Scholar] [CrossRef]
- Tatullo, M.; Codispoti, B.; Paduano, F.; Nuzzolese, M.; Makeeva, I. Strategic Tools in Regenerative and Translational Dentistry. Int. J. Mol. Sci. 2019, 16, 1879. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Malò, P.; Friberg, B.; Polizzi, G.; Gualini, F.; Vighagen, T.; Rangert, B. Immediate and early function of Branemark System implants placed in the esthetic zone: A 1-year prospective clinical multicenter study. Clin. Implant. Dent. Relat. Res. 2003, 5, 37–46. [Google Scholar] [CrossRef]
- Malo, P.; de Araújo Nobre, M.; Lopes, A.; Moss, S.M.; Molina, G.J. A longitudinal study of the survival of All-on-4 implants in the mandible with up to 10 years of follow-up. J. Am. Dent. Assoc. 2011, 142, 310–320. [Google Scholar] [CrossRef]
- Figliuzzi, M.M.; Giudice, A.; Pileggi, S.; Pacifico, D.; Marrelli, M.; Tatullo, M.; Fortunato, L. Implant-Prosthetic Rehabilitation in Bilateral Agenesis of Maxillary Lateral Incisors with a Mini Split Crest. Case Rep. Dent. 2016, 2016, 3591321. [Google Scholar] [CrossRef] [Green Version]
- Wma Declaration of Helsinki–Ethical Principles for Medical Research Involving Human Subjects. Available online: https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/ (accessed on 2 December 2021).
- Grandi, T.; Guazzi, P.; Samarani, R.; Grandi, G. Immediate loading of four (all-on-4) post-extractive implants supporting mandibular cross-arch fixed prostheses: 18-month follow-up from a multicentre prospective cohort study. Eur. J. Oral Implantol. 2012, 5, 277–285. [Google Scholar]
- Att, W.; Stappert, C. Implant therapy to improve quality of life. Quintessence Int. 2003, 34, 573–581. [Google Scholar]
- Engquist, B.; Bergendal, T.; Kallus, T.; Linden, U. A retrospective multicenter evaluation of osseointegrated implants supporting overdentures. Int. J. Oral Maxillofac. Implant. 1988, 3, 129–134. [Google Scholar]
- Ballini, A.; Boccaccio, A.; Saini, R.; Van Pham, P.; Tatullo, M. Dental-Derived Stem Cells and Their Secretome and Interactions with Bioscaffolds/Biomaterials in Regenerative Medicine: From the In Vitro Research to Translational Applications. Stem. Cells Int. 2017, 2017, 6975251. [Google Scholar] [CrossRef]
- Del Fabbro, M.; Bellini, C.M.; Romeo, D.; Francetti, L. Tilted implants for the rehabilitation of edentulous jaws: A systematic review. Clin. Implant. Dent. Relat. Res. 2012, 14, 612–621. [Google Scholar] [CrossRef]
- Heydecke, G.; Zwahlen, M.; Nicol, A.; Nisand, D.; Payer, M.; Renouard, F.; Grohmann, P.; Muhlemann, S.; Joda, T. What is the optimal number of implants for fixed reconstructions: A systematic review. Clin. Oral Implant. Res. 2012, 23, 217–228. [Google Scholar] [CrossRef] [PubMed]
- Ata-Ali, J.; Penarrocha-Oltra, D.; Candel-Marti, E.; Penarrocha-Diago, M. Oral rehabilitation with tilted dental implants: A metaanalysis. Med. Oral Patol. Oral Cir. Bucal 2012, 17, e582–e587. [Google Scholar] [CrossRef] [Green Version]
- Menini, M.; Signori, A.; Tealdo, T.; Bevilacqua, M.; Pera, F.; Ravera, G.; Pera, P. Tilted implants in the immediate loading rehabilitation of the maxilla: A systematic review. J. Dent. Res. 2012, 91, 821–827. [Google Scholar] [CrossRef] [PubMed]
- Tatullo, M.; Spagnuolo, G.; Codispoti, B.; Zamparini, F.; Zhang, A.; Esposti, M.D.; Aparicio, C.; Rengo, C.; Nuzzolese, M.; Manzoli, L.; et al. PLA-Based Mineral-Doped Scaffolds Seeded with Human Periapical Cyst-Derived MSCs: A Promising Tool for Regenerative Healing in Dentistry. Materials 2019, 12, 597. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Codispoti, B.; Marrelli, M.; Paduano, F.; Tatullo, M. NANOmetric BIO-Banked MSC-Derived Exosome (NANOBIOME) as a Novel Approach to Regenerative Medicine. J. Clin. Med. 2018, 15, 357. [Google Scholar] [CrossRef] [Green Version]
- Bijelic, R.; Milicevic, S.; Balaban, J. Risk Factors for Osteoporosis in Postmenopausal Women. Med. Arc. 2017, 71, 25–28. [Google Scholar] [CrossRef] [Green Version]
- Langsted, A.; Nordestgaard, B.G. Smoking is Associated with Increased Risk of Major Bleeding: A Prospective Cohort Study. Thromb. Haemost. 2019, 119, 39–47. [Google Scholar] [CrossRef]
- Gardin, C.; Bosco, G.; Ferroni, L.; Quartesan, S.; Rizzato, A.; Tatullo, M.; Zavan, B. Hyperbaric Oxygen Therapy Improves the Osteogenic and Vasculogenic Properties of Mesenchymal Stem Cells in the Presence of Inflammation In Vitro. Int. J. Mol. Sci. 2020, 21, 1452. [Google Scholar] [CrossRef] [Green Version]
- Tatullo, M.; Genovese, F.; Aiello, E.; Amantea, M.; Makeeva, I.; Zavan, B.; Rengo, S.; Fortunato, L. Phosphorene Is the New Graphene in Biomedical Applications. Materials 2019, 12, 2301. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Goldstein, G.; DeSantis, L.; Goodacre, C. Bruxism: Best Evidence Consensus Statement. J. Prosthodont. 2021, 30, 91–101. [Google Scholar] [CrossRef]
- Signorini, L.; Faustini, F.; Samarani, R.; Grandi, T. Immediate fixed rehabilitation supported by pterygoid implants for participants with severe maxillary atrophy: 1-Year postloading results from a prospective cohort study. J. Prosthet. Dent. 2020, 3, 67–75. [Google Scholar] [CrossRef] [PubMed]
- Borgonovo, A.; Grandi, T.; Vassallo, S.; Signorini, L. Extrasinus Zygomatic Implants for the Immediate Rehabilitation of the Atrophic Maxilla: 1-Year Postloading Results From a Multicenter Prospective Cohort Study. J. Oral Maxillofac. Surg. 2021, 79, 356–365. [Google Scholar] [CrossRef] [PubMed]
- Pistilli, R.; Signorini, L.; Pisacane, A.; Lizio, G.; Felice, P. Case of severe bone atrophy of the posterior maxilla rehabilitated with blocks of equine origin bone: Histological results. Implant. Dent. 2013, 22, 8–15. [Google Scholar] [CrossRef] [PubMed]
- Aparicio, C.; Manresa, C.; Francisco, K.; Claros, P.; Alández, J.; González-Martín, O.; Albrektsson, T. Zygomatic implants: Indications, techniques and outcomes, and the zygomatic success code. Periodontology 2000 2014, 66, 41–58. [Google Scholar] [CrossRef]
Diameters | Length | Insertion Torque (Ncm) | |
---|---|---|---|
3.2 mm: 18 (4.7%) | 10 mm: 11 (2.9%) | 30 n: 7 (1.82%) | 50 n: 3 (0.78%) |
3.7 mm: 300 (78.1%) | 11.5 mm: 82 (21.4%) | 35 n: 6 (1.56%) | 60 n: 70 (18.22%) |
4.3 mm: 65 (16.9%) | 13 mm: 221 (57.6%) | 40 n: 1 (0.26%) | 70 n: 2 (0.52%) |
5.0 mm: 1 (0.3%) | 15 mm: 70 (18.1%) | 45 n: 23 (5.99%) | 80 n: 272 (70.8%) |
Patients n = 96 | |
---|---|
Age (years) | 66.0 ± 7.2 (range 42–86 years) |
Male/Female | 39 (40.6%)/57 (59.4%) |
Smoke | No: 70 (72.9%) <10 cigarettes/day: 20 (20.8%) >10/<20 cigarettes/day: 6 (6.3%) |
Initial situation | Edentulous: 15 (15.6%) Terminal dentition: 81 (84.4%) |
Co-morbidities | Hypertension 33/96 (34.9%) Controlled Diabetes 10/96 (10.4%) Hyperthyroidsm 7/96 (7.3%) Osteoporosis 6 (6.3%) |
Factor | OR (95% CI) | p | OR a (95% CI) | p |
---|---|---|---|---|
Age | 1.0 (0.9–1.1) | 0.92 | ||
Smokers | 7.3 (2.0–27.1) | 0.003 | 9.9 (2.3–43.9) | 0.002 |
Mechanical Complications | 1.4 (0.4–5.1) | 0.60 | ||
Biological Complications | 10.4 (5.1–20.2) | 0.001 | 13.4 (6.3–17.2) | 0.0001 |
Opposing Dentition | 1.7 (0.8–5.2) | 0.34 | ||
Systemic conditions | 0.5 (0.2–1.8) | 0.31 |
Factor | OR (95% CI) | p | OR a (95% CI) | p |
---|---|---|---|---|
Age | 1.0 (0.9–1.1) | 0.47 | ||
Smokers | 7.7 (2.6–23.1) | 0.0003 | 11.3 (3.2–39.7) | 0.001 |
Mechanical Complications | 1.3 (0.4–3.9) | 0.62 | ||
Opposing Dentition | 1.5 (0.6–4.0) | 0.76 | ||
Systemic conditions | 0.8 (0.3–2.6) | 0.80 |
Factor | OR (95% CI) | p | OR a (95% CI) | p |
---|---|---|---|---|
Age | 1.0 (0.9–1.1) | 0.89 | ||
Smokers | 1.6 (0.6–4.4) | 0.31 | ||
Biological Complications | 1.3 (0.4–3.9) | 0.62 | ||
Bruxism | 8.7 (2.4–13.8) | 0.001 | 7.9 (1.7–36.6) | 0.008 |
Opposing dentition | 1.3 (0.4–3.9) | 0.66 | ||
Systemic conditions | 1.5 (0.5–4.3) | 0.42 |
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Grandi, T.; Signorini, L. Rehabilitation of the Completely Edentulous Mandible by All-on-Four Treatment Concept: A Retrospective Cohort Study with Up to 10 Years Follow-Up. Medicina 2022, 58, 10. https://doi.org/10.3390/medicina58010010
Grandi T, Signorini L. Rehabilitation of the Completely Edentulous Mandible by All-on-Four Treatment Concept: A Retrospective Cohort Study with Up to 10 Years Follow-Up. Medicina. 2022; 58(1):10. https://doi.org/10.3390/medicina58010010
Chicago/Turabian StyleGrandi, Tommaso, and Luca Signorini. 2022. "Rehabilitation of the Completely Edentulous Mandible by All-on-Four Treatment Concept: A Retrospective Cohort Study with Up to 10 Years Follow-Up" Medicina 58, no. 1: 10. https://doi.org/10.3390/medicina58010010