Search Results (229)

Gopher tortoises (Gopherus polyphemus) are threatened burrowing keystone ecosystem engineers indigenous to open uplands in the Southeastern United States. Perils to the species include habitat degradation and fragmentation, anthropogenic disturbances, predation, parasites, and disease. Problems are severe in the SE Florida study area due to coastal urban sprawl, confining the tortoises in small, scattered, unnatural pockets subject to novel stresses. The annual South Florida February to ca. late May dry season became a severe drought in 2025. The present project centered on the broad question of foodplant resilience through the drought. The tortoise-grazed areas host three dominant groundcover species, in order of abundance: non-native Richardia grandiflora, native grass Paspalum setaceum, and non-native sedge Fimbristylis cymosa. Key findings were as follows: 1. The most abundant and most-often grazed species, Richardia grandiflora, when tortoises were excluded, expanded despite the drought (from 39% to 49.5% mean coverage). Under combined drought and grazing, that species cover decreased slightly (42.5% to 39.4%). Tortoise-free, Paspalum setaceum declined slightly during the drought (32.7% to 27.1% mean coverage), and showed mixed results with little net effect exposed to drought and to grazing. Never observed to be grazed during the study, Fimbristylis cymosa formed a nearly monospecific lawn in a sizeable portion of the study area. During the drought, it mostly browned, retaining green rosette centers, and tortoise exclusion showed no discernable effect. With transition to late spring, however, with increased rainfall, tortoise exclusion allowed rapid competition from grasses among the Fimbristylis rosettes. Adjacent unenclosed grazing, by contrast, maintained the Fimbristylis lawn without increase in grass coverage. Conclusions are that the two chief “fodder” species, Richardia grandiflora and Paspalum setaceum, were robust to drought and grazing. The introduced Fimbristylis cymosa appears to be facilitated by selective grazing-suppressing grass competitors. Full article

The cislunar space navigation satellite system is essential infrastructure for lunar exploration in the next phase. It relies on high-precision orbit determination to provide the reference of time and space. This paper focuses on constructing a navigation constellation using special orbital locations such as Earth–Moon libration points and distant retrograde orbits (DRO), and it discusses the simplification of planetary perturbation models for their autonomous orbit determination on board. The gravitational perturbations exerted by major solar system bodies on spacecraft are first analyzed. The minimum perturbation required to maintain a precision of 10 m during a 30-day orbit extrapolation is calculated, followed by a simulation analysis. The results indicate that considering only gravitational perturbations from the Moon, Sun, Venus, Saturn, and Jupiter is sufficient to maintain orbital prediction accuracy within 10 m over 30 days. Based on these findings, a method for simplifying the ephemeris is proposed, which employs Hermite interpolation for the positions of the Sun and Moon at fixed time intervals, replacing the traditional Chebyshev polynomial fitting used in the JPL DE ephemeris. Several simplified schemes with varying time intervals and orders are designed. The simulation results of the inter-satellite links show that, with a 6-day orbit arc length, a 1-day lunar interpolation interval, and a 5-day solar interpolation interval, the accuracy loss for cislunar space navigation satellites remains within the meter level, while memory usage is reduced by approximately 60%. Full article

The matrix metalloproteinase (MMP) family includes several membrane-bound enzymes. Membrane-type 5 matrix metalloproteinase (MT5-MMP) is unique amongst the MMP family in being primarily expressed in the brain and during development. It is proposed to contribute to synaptic plasticity and is implicated in several pathologies, including multiple cancers and Alzheimer’s disease. In cancer, MT5-MMP expression has been correlated to cancer progression, but a distinct mechanistic role has yet to be uncovered. In Alzheimer’s disease, MT5-MMP exhibits pro-amyloidogenic activity, functioning as an η-secretase that cleaves amyloid precursor protein (APP), ultimately generating two synaptotoxic fragments, Aη-α and Aη-β. Several intracellular binding partners for MT5-MMP have been identified, and of these, N4BP2L1, EIG121, BIN1, or TMX3 binding to MT5-MMP results in a significant increase in MT5-MMP η-secretase activity. Beyond direct effects on APP, MT5-MMP may also facilitate APP trafficking to endosomal/lysosomal compartments and enhance proinflammatory responses. Overall, the substrate profile of MT5-MMP has not been well defined, and selective inhibitors of MT5-MMP have not been described. These advances will be needed for further consideration of MT5-MMP as a therapeutic target in Alzheimer’s disease and other pathologies. Full article

During the 1970s’ military dictatorships in Chile and Brazil, the Catholic Church took the position of moral opposition to the authoritarian regimes, while in Argentina, the Church sided with the dictatorship. In his pathbreaking book utilizing the religious economy model, Anthony Gill theorized that the Church in Chile adopted a critical stance against the regime due to competition from Protestant Churches. Subsequently, Gill’s specific arguments and the religious economy model in general have been widely applied but also critiqued by sociologists of religion. Through a deeper analysis of the three case studies of Argentina, Chile, and Brazil, we support and extend theoretical critiques of the religious economy model. We argue that that the religious economy model as applied by Gill is an insufficient predictor of church and state behavior because it lacks specificity on the amount of competition necessary to warrant taking progressive action, lacks specificity about the timing of Protestant competition, ignores the pre-existing position of the Catholic Church, treats the demand side of the religious market as inelastic, assumes the Catholic Church intentionally implemented progressive policies in response to competition, presumes the Church is a unitary actor, and disregards the impact of a perceived Marxist threat on both church and state actors. Our critique of the religious economy model points to refinements of the model and alternative approaches to understanding church and state behavior in Latin America and elsewhere. Full article

Polycarbonate laboratory safety glasses and facial shields were tested for impact resistance. Impacts from 22-caliber bullets fired from a firearm were compared with impacts of pellets fired from an air rifle. A low-weight pellet fired from an air rifle is a suitable and safer alternative to the use of a firearm. The results show that if there is a need for protection from flying projectiles, one should use multiple layers of protection. Furthermore, already-damaged protective equipment, even if the damage appears to be minor, may not provide any protection and should not be used. The resulting impacted polycarbonate lenses and sheets were used in a classroom discussion with the undergraduate chemistry students about polymer properties and adequate safety protection. Full article

Background: Disparities in neuro-oncological care between high-income and low- and middle-income countries (LMICs) are well documented, yet region-specific data from Latin America remain limited. This review evaluates epidemiologic trends, access to care, and systemic challenges in brain tumor management across Latin American LMICs, using Argentina as a case study. Methods: A systematic review of peer-reviewed literature was conducted focusing on brain tumor incidence, mortality, risk factors, and availability of diagnostics and treatments in Latin America. Socioeconomic, cultural, and systemic barriers were also analyzed. Results: Latin America exhibits some of the highest global brain tumor mortality rates, with Brazil reporting age-standardized rates exceeding 4.5 per 100,000. Glioblastomas are frequently diagnosed at younger ages, often in the fifth decade of life, compared to the global average. Meningioma incidence has increased by 15–20% over the last decade, yet region-wide data remain fragmented. Access to neuroimaging, neurosurgery, radiotherapy, and chemotherapy is limited, with up to 60% of patients relying solely on under-resourced public health systems. Less than 30% of hospitals in rural areas have MRI availability, and continuous professional training is infrequent. Innovative adaptations, such as awake craniotomy, are used in some LMIC centers in response to equipment scarcity. Conclusions: Brain tumor care in Latin America is hindered by limited epidemiological data, restricted access to diagnostics and treatment, and insufficient workforce training. Targeted investments in healthcare infrastructure, international educational collaborations, and policy-level reforms are critical to reducing disparities and improving outcomes in neuro-oncology across the region. Full article

Experimental and theoretical design on thermal and structural properties of Cu-Zn-Al alloys are established. As such, from an experimental point of view, differential thermal analysis has been performed with the help of a DSC Netzsch STA 449 F1 Jupiter calorimeter with high levels of sensitivity, and the structural analysis has been accomplished through X-ray diffraction and SEM analysis. An unusual specific property for a metallic material has been discovered, which is known as “rubber-type behavior”, a characteristic determined by micro-structural changes. From the theoretical point of view, the thermal transfer in Cu-Zn-Al is presented by assimilating this alloy, both structurally and functionally, with a multifractal, situation in which the order–disorder transitions assimilated with thermal “dynamics” of Cu-Zn-Al, are mimed through transitions from non-multifractal to multifractal curves. In such a context, the thermal expansion velocity contains both the propagation speed of the phase transformation (be it a direct one: austenitic–martensitic transformation, or an indirect one: martensitic–austenitic transformation) and the thermal diffusion speed. Then, through self-modulations of the thermal field, the Cu-Zn-Al alloy will self-structure in channel-type or cellular-type thermal patterns, which can be linked to obtained experimental data. Consequently, since the thermal conductivity becomes a function of the observation scale, and heat transfer is modified to reflect the multifractal, non-differentiable paths in the material, it leads to anomalous diffusion and complex thermal behaviors. Full article

Background/Objectives: Distal radius fractures (DRFs) are among the most common fractures in the elderly, with increasing incidence due to population aging. Recent evidence questions the benefits of operative treatment, particularly in elderly patients. The present study aimed to assess post-traumatic osteoarthritis (OA) and patient-reported outcome measures (PROMs) after a minimum of two years of follow-up of the previously published VOLCON randomized controlled trial (RCT), which compared operative and non-operative treatments of unstable DRFs in patients aged ≥ 65 years. Methods: This study presents a minimum two-year follow-up of a single-center, assessor-blinded RCT. A total of 100 patients with unstable DRFs were randomized to either operative treatment with volar locking plating or non-operative treatment with cast immobilization. The primary outcome was post-traumatic OA, assessed using the Knirk and Jupiter classification. Secondary outcomes included PROMs (Quick Disabilities of the Arm, Shoulder, and Hand (Quick-DASH)) and Patient-Rated Wrist/Hand Evaluation (PRWHE), complications, pain, grip strength, and range of motion (ROM). Statistical analyses were performed using two-way ANOVA. Results: After a median follow-up of 3.0 years, 60 patients (28 non-operative and 32 operative) were available for analysis. There was no significant difference in OA between the groups (p = 0.57). PROMs (Quick-DASH, PRWHE), pain, grip strength, and ROM were time-dependent (p < 0.001) but not treatment-dependent. Complications were more frequent in the operative group, including hardware-related issues requiring reoperation. Conclusions: At a minimum of two years of follow-up, no correlation was found between treatment choice and post-traumatic OA. Functional outcomes were similar between groups, suggesting that non-operative treatment remains a viable option for elderly patients with unstable DRFs. Full article

Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by motor and non-motor dysfunctions that severely compromise patients’ quality of life. While pharmacological treatments provide symptomatic relief in the early stages, advanced PD often requires neurosurgical interventions, such as deep brain stimulation (DBS) and focused ultrasound (FUS), for effective symptom management. A significant challenge in optimizing these therapeutic strategies is the early identification and recruitment of suitable candidates for clinical trials. This review explores the role of artificial intelligence (AI) in advancing neurosurgical and neuroscience interventions for PD, highlighting the ways in which AI-driven platforms are transforming clinical trial design and patient selection. Machine learning (ML) algorithms and big data analytics enable precise patient stratification, risk assessment, and outcome prediction, accelerating the development of novel therapeutic approaches. These innovations improve trial efficiency, broaden treatment options, and enhance patient outcomes. However, integrating AI into clinical trial frameworks presents challenges such as data standardization, regulatory hurdles, and the need for extensive validation. Addressing these obstacles will require collaboration among neurosurgeons, neuroscientists, AI specialists, and regulatory bodies to establish ethical and effective guidelines for AI-driven technologies in PD neurosurgical research. This paper emphasizes the transformative potential of AI and technological innovation in shaping the future of PD neurosurgery, ultimately enhancing therapeutic efficacy and patient care. Full article

Fluorescent cholesterol probes are indispensable tools for studying membrane structure, dynamics, and trafficking. To better understand the structure–function relationship of fluorescent cholesteryl probes, we developed a series of five new modular naphthalimide-containing cholesteryl probes (CND15–CND19). These probes incorporate an L-lysine linker between the cholesterol moiety and the fluorophore, along with a series of distinct head groups. We conducted extensive biophysical characterizations of these probes, including the determination of their solvatochromic properties and lipid partitioning behavior using giant unilamellar vesicles. Molecular dynamics simulations were employed to identify key molecular interactions of these probes within model lipid membranes. Furthermore, live-cell imaging in 3T3 fibroblasts demonstrated the potential applications of these analogs in live-cell imaging, measuring cellular membrane dynamics and studying cholesterol-related processes. The results of this study underscore the critical role of the linker and head group in designing fluorescent cholesterol-mimicking probes. These findings provide valuable insights into optimizing probe designs for future cholesterol and membrane biology research. Full article

When a star is born, a protoplanetary disk made of gas and dust surrounds the star. The disk can show gaps opened by different astrophysical mechanisms. The gap has a wall emitting radiation, which contributes to the spectral energy distribution (SED) of the whole system (star, disk and planet) in the IR band. As these newborn stars are far away from us, it is difficult to know whether the gap is opened by a forming planet. I have developed RHADaMAnTe, a computational astro code based on the geometry of the wall of a gap coming from hydrodynamics 3D simulations of protoplanetary disks. With this code, it is possible to make models of disks to estimate the synthetic SEDs of the wall and prove whether the gap was opened by a forming planet. An implementation of this code was used to study the stellar system LkCa 15. It was found that a planet of 10 Jupiter masses is capable of opening a gap with a curved wall with a height of 12.9 AU. However, the synthetic SED does not fit to Spitzer IRS SED (${\chi }^2$∼4.5) from $5\mathsf{\mu }$m to $35\mathsf{\mu }$m. This implies that there is an optically thin region inside the gap. Full article

Monteggia fractures represent complex injuries requiring careful assessment and surgical intervention. This case report presents a rare variation of a Bado type I Monteggia fracture–dislocation that resembles features from the Jupiter subclassification type IID. A 39-year-old male sustained a high-energy injury while riding an all-terrain vehicle, resulting in a proximal segmental ulnar shaft fracture with anterior radial head dislocation. Open reduction and internal fixation (ORIF) of the ulna using a pre-contoured proximal ulna low-contact dynamic compression plate (LC-DCP) successfully restored alignment, leading to spontaneous reduction of the radial head. The postoperative course was uneventful, with satisfactory healing and functional recovery. This case underscores the importance of meticulous ulnar reconstruction in Monteggia fracture–dislocations and contributes to the limited literature on anterior radial head dislocation patterns. Full article

The study of woody dicot xylem structure in relation to habitats has a long but geographically incomplete history, generating generalizations and questions still in need of expanded data. One understudied area is localized cross-habitat studies under identical climate conditions. Also sparse are intraspecific cross-habitat data. Both of these weaknesses are addressed in the present project for unstudied S. Florida. Six surveys of woody dicot branchlet microtome cross-sections allowed the microscopic comparison of vessel element (VE) diameters and VE densities. The project took place in a small area within short timeframes per survey to assure near uniformity in weather and in seasonal growth cycles. The multispecies Initial Survey and single-species Ximenia americana Survey addressed the question of adjustments in VE diameters and/or VE densities in shaded vs. sunny habitats, finding significant downward average adjustment in VE densities in shaded hammock vs. open pineland habitats (112 shade vs. 182 VE/mm² sun) but not in VE diameters. Single-species (Chrysobalanus icaco, Morella cerifera) surveys examined adjustments in VE diameters and VE densities in swamp vs. scrub (diameter mean: 42.5 µm swamp, 49.2 µm scrub; density means: 179.9 swamp, 154.0 scrub). Chrysobalanus icaco, having arguably the greatest environmental breadth and having the largest mean vessel element diameters in the project, was the sole species to adjust VE diameters only across habitats. Coefficients of variation in VE density exceeded those in VE diameters in every survey. This project sets the stage for future work in Florida and beyond aimed at isolation of environmental variables with respect to xylem traits and aimed at causal mechanisms, especially mode of xylem adjustment in relation to conductive risk. Full article

In the past, measures of the “Earth-likeness” of exoplanets have been qualitative, considering an abiotic Earth, or requiring discretionary choices of what parameters make a planet Earth-like. With the advent of high-resolution exoplanet spectroscopy, there is a growing need for a method of quantifying the Earth-likeness of a planet that addresses these issues while making use of the data available from modern telescope missions. In this work, we introduce an informational–entropic metric that makes use of the spectrum of an exoplanet to directly quantify how Earth-like the planet is. To illustrate our method, we generate simulated transmission spectra of a series of Earth-like and super-Earth exoplanets, as well as an exoJupiter and several gas giant exoplanets. As a proof of concept, we demonstrate the ability of the information metric to evaluate how similar a planet is to Earth, making it a powerful tool in the search for a candidate Earth 2.0. Full article

Probenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion in the kidney, affecting both endogenous substances like uric acid and exogenous ones like penicillin. Beyond its renal applications, probenecid has shown capabilities in crossing the blood–brain barrier and modulating the activity of various membrane channels and transporters. This compound has emerged as a potent antiviral agent, demonstrating efficacy against multiple viruses, including influenza, COVID-19, and RSV. Clinical trials with COVID-19 patients have confirmed its antiviral potential, sparking further investigation into its mechanisms of action. This study explores probenecid’s significant anti-inflammatory properties, focusing on its ability to inhibit inflammasome activation. Our study aims to unravel the anti-inflammatory effects of probenecid on the NLRP3 inflammasome and MAPK signaling pathways using murine macrophages as a relevant inflammation model. We reveal that probenecid treatment blocks JNK and ERK signaling without affecting p38 MAPK, suppressing NLRP3 inflammasome activation. Additionally, probenecid does not affect NFκB-directed protein expression, although it efficiently inhibits NLRP3 inflammasome outputs, e.g., IL-1β and pyroptosis. These results indicate probenecid’s potential therapeutic applications. Full article