Search Results (40)

Background/Objectives: The combination of denosumab treatment with biological disease-modifying antirheumatic drugs (bDMARDs) or targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) in patients with inflammatory rheumatic diseases (IRD) may raise safety concerns for clinicians, particularly regarding infections. In this study, we investigated whether the risk of infection increases in patients who receive bDMARDs or tsDMARDs for IRD and are simultaneously treated with denosumab for osteoporosis (OP). Methods: As a control group, we evaluated patients receiving bDMARDs or tsDMARDs concomitantly with zoledronic acid (ZA), which is not clearly associated with infections. A total of 88 patients—including 30 patients receiving bDMARDs or tsDMARDs with ZA and 58 patients receiving bDMARDs or tsDMARDs with denosumab—met the criteria and were included in this study. The groups were compared in terms of the ratio/risk of serious infections requiring hospitalisation and infections requiring outpatient treatment after applying the inverse probability of treatment weighting (IPTW) to the control for confounding factors. The Cox proportional hazards regression model was used to compare the risks of infection, taking confounding factors into account. Results: The mean age of patients in the ZA group was 59.07 years (±SD: 13.65), while that of patients in the denosumab group was 69.93 years (±SD: 11.72). Comorbidities occurred more frequently in the denosumab group (n = 44, 75.86%) than in the ZA group (n = 14, 46.66%). The median duration of medication use in the denosumab group was 24 months (minimum: 6 months; maximum: 72 months). The median duration of medication use in the ZA group was 24 months (minimum: 12 months; maximum: 60 months). When comparing the groups regarding the risk of infection, denosumab was not associated with an increased risk of either a serious infection requiring hospitalisation (Hazard Ratio (HR): 0.37; 95% Confidence Interval (CI): 0.14–0.94) or an infection requiring outpatient treatment (HR: 0.29; 95% CI: 0.12–0.71). Conclusions: In conclusion, the combination of denosumab treatment with bDMARD or tsDMARD treatments is safe for short-term use. Full article

Ammonia (NH₃), as a vital component of the nitrogen cycle, exerts significant influence on the biosphere, air quality, and climate by contributing to secondary aerosol formation through its reactions with sulfur dioxide (SO₂) and nitrogen oxides (NO_x). Despite its critical environmental role, NH₃’s transient atmospheric lifetime and the variability in spatial and temporal distributions pose challenges for effective global monitoring and comprehensive impact assessment. Recognizing the inadequacies in current in situ measurement capabilities, this study embarked on an extensive analysis of NH₃’s temporal and spatial characteristics over East Asia, using the Infrared Atmospheric Sounding Interferometer (IASI) onboard the MetOp-B satellite from 2013 to 2024. The atmospheric NH₃ concentrations exhibit clear seasonality, beginning to rise in spring, peaking in summer, and then decreasing in winter. Overall, atmospheric NH₃ shows an annual increasing trend, with significant increases particularly evident in Eastern China, especially in June. The regional NH₃ trends within China have varied, with steady increases across most regions, while the Northeastern China Plain remained stable until a recent rapid rise. South Korea continues to show consistent and accelerating growth. East Asia demonstrates similar NH₃ emission characteristics, driven by farmland and livestock. The spatial and temporal inconsistencies between satellite data and global chemical transport models underscore the importance of establishing accurate NH₃ emission inventories in East Asia. Full article

The Flexible Combined Imager (FCI), developed as the next-generation imager for the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) Meteosat Third Generation (MTG) satellite series, represents a significant advancement over its predecessor, SEVIRI, on the Meteosat Second Generation (MSG) satellites. FCI offers more spectral bands, higher spatial resolution, and faster imaging capabilities, supporting a wide range of applications in weather forecasting, climate monitoring, and environmental analysis. On 13 January 2024, the FCI onboard MTG-I1 (renamed Meteosat-12 in December 2024) experienced a critical anomaly involving the failure of its onboard Calibration and Obturation Mechanism (COM). As a result, the use of the COM was discontinued to preserve operational safety, leaving the instrument dependent on alternative calibration methods. This loss of onboard calibration presents immediate challenges, particularly for the infrared channels, including image artifacts (e.g., striping), reduced radiometric accuracy, and diminished stability. To address these issues, EUMETSAT implemented an external calibration approach leveraging algorithms from the Global Space-based Inter-Calibration System (GSICS). The inter-calibration algorithm transfers stable and accurate calibration from the Infrared Atmospheric Sounding Interferometer (IASI) hyperspectral instrument aboard Metop-B and Metop-C satellites to FCI’s infrared channels daily, ensuring continued data quality. Comparisons with Cross-track Infrared Sounder (CrIS) data from NOAA-20 and NOAA-21 satellites using a similar algorithm is then used to validate the radiometric performance of the calibration. This confirms that the external calibration method effectively compensates for the absence of onboard blackbody calibration for the infrared channels. For the visible and near-infrared channels, slower degradation rates and pre-anomaly calibration ensure continued accuracy, with vicarious calibration expected to become the primary source. This adaptive calibration strategy introduces a novel paradigm for in-flight calibration of geostationary instruments and offers valuable insights for satellite missions lacking onboard calibration devices. This paper details the COM anomaly, the external calibration process, and the broader implications for future geostationary satellite missions. Full article

This study presents an objective scheme to construct hurricane bogus vortices based on satellite microwave scatterometer observations of sea surface wind vectors. When specifying a bogus vortex using Fujita’s formula, the required parameters include the center position and the radius of the maximum gradient of sea level pressure (R₀). We first propose determining the tropical cyclone (TC) center position as the cyclonic circulation center obtained from sea surface wind observations and then establishing a regression model between R₀ and the radius of 34-kt sea surface wind of scatterometer observations. The radius of 34-kt sea surface wind (R₃₄) is commonly used as a measure of TC size. The center positions determined from HaiYang-2B/2C/2D Scatterometers, MetOp-B/C Advanced Scatterometers, and FengYun-3E Wind Radar compared favorably with the axisymmetric centers of hurricane rain/cloud bands revealed by Advanced Himawari Imager observations of brightness temperature for the western Pacific landfalling typhoons Doksuri, Khanun, and Haikui in 2023. Furthermore, regression equations between R₀ and the scatterometer-determined radius of 34-kt wind are developed for tropical storms and category-1, -2, -3, and higher hurricanes over the Northwest Pacific (2022–2023). The bogus vortices thus constructed are more realistic than those built without satellite sea surface wind observations. Full article

In the past decades, satellite hyperspectral remote sensing instruments have been providing key measurements for environmental monitoring, such as the analysis of water and air quality, soil usage, weather forecasting, or climate change. The success of this technology, however, relies on an accurate knowledge of the instrument’s spectral response functions (SRFs). Usually, the SRFs are assessed on-ground and then monitored on-flight using tedious analysis of the acquired radiances coupled with instrumental models; nonetheless, the complete retrieval of the SRFs is generally out of reach. In this context, EUMETSAT has developed a novel SRF retrieval methodology, with the intention of applying it routinely to the current Metop IASI instruments and soon to Metop-SG IASI-NG, and MTG-S IRS. By making use of spatiotemporal colocations of different detectors within a single instrument or between different platforms, relative SRFs may be retrieved on-flight without any a priori knowledge. The presented methodology is suited for instruments acquiring radiances with contiguous sampling over large spectral bands as the SRFs are retrieved by analyzing the neighboring channels’ correlations. This article focuses on Fourier transform spectrometers (FTS) in the far infrared as they possess these characteristics per design, but it is believed that the method could be extended to other technology and spectral bands. The SRFs are further processed to evaluate the relative self-apodization functions (SAFs), as they represent the discrepancies between the detectors at the interferograms level, the primary measurements of FTS. The following article presents both simulations and applications of the SRF retrieval for the three IASI instruments aboard the Metop platforms of the EPS program. We analyze both IASI sensors aboard Metop-B and C as well as the evolution of Metop-A IASI over 13 years of operation. Full article

A polarized bidirectional reflectance distribution function (pBRDF) matrix was developed based on the two-scale roughness theory to provide consistent simulations of fully polarized microwave emission and scattering, required for the ocean–atmosphere-coupled radiative transfer model. In this study, the potential of the two-scale pBRDF matrix was explored for simulating ocean full-polarization backscattering and bistatic-scattering normalized radar cross sections (NRCSs). Comprehensive numerical simulations of the two-scale pBRDF matrix across the L-, C-, X-, and Ku-bands were carried out, and the simulations were compared with experimental data, classical electromagnetic, and GMFs. The results show that the two-scale pBRDF matrix demonstrates reasonable dependencies on ocean surface wind speeds, relative wind direction (RWD), geometries, and frequencies and has a reliable accuracy in general. In addition, the two-scale pBRDF matrix simulations were compared with the observations from the advanced scatterometer (ASCAT) onboard MetOP-C satellites, with a correlation coefficient of 0.9634 and a root mean square error (RMSE) of 2.5083 dB. In the bistatic case, the two-scale pBRDF matrix simulations were compared with Cyclone Global Navigation Satellite System (CYGNSS) observations, demonstrating a good correlation coefficient of 0.8480 and an RMSE of 1.2859 dB. In both cases, the two-scale pBRDF matrix produced fairly good simulations at medium-to-high wind speeds. The relatively large differences at low wind speeds (<5 m/s) were due probably to the swell effects. This study proves that the two-scale pBRDF matrix is suitable for the applications of multiple types of active instruments and can consistently simulate the ocean surface passive and active signals. Full article

Severe acute respiratory tract infections (SARIs) has been well described in South Africa with seasonal patterns described for influenza and respiratory syncytial virus (RSV), while others occur year-round (rhinovirus and adenovirus). This prospective syndromic hospital-based surveillance study describes the prevalence and impact of public interventions on the seasonality of other respiratory pathogens during the coronavirus disease-19 (COVID-19) pandemic. This occurred from August 2018 to April 2022, with 2595 patients who met the SARS case definition and 442 controls, from three sentinel urban and rural hospital sites in South Africa. Naso/oro-pharyngeal (NP/OP) swabs were tested using the FastTrack Diagnostics^® Respiratory pathogens 33 (RUO) kit. Descriptive statistics, odds ratios, and univariate/multivariate analyses were used. Rhinovirus (14.80%, 228/1540) and Streptococcus pneumoniae (28.50%, 439/1540) were most frequently detected in NP/OP swabs and in children <1 years old (35%, 648/1876). Among others, pathogens associated with SARI cases causing disease were influenza A&B, HRV, RSV, hCoV 229e, Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pneumoniae. Pre-COVID-19, seasonal trends of these pathogens correlated with previous years, with RSV and influenza A seasons only resuming after the national lockdown (2021). It is evident that stringent lockdown conditions have severe impacts on the prevalence of respiratory tract infections. Full article

Observations from the Advanced Microwave Sounding Unit-A (AMSU-A) onboard polar-orbiting satellites are considered to be the most effective satellite data in terms of obviously reducing operational prediction errors. However, there are still significant difficulties in the application of AMSU-A low-level channel data assimilation over land. One of them is the inaccurate surface skin temperature (SKT) of the background on land areas, which leads to significant uncertainty in the accuracy of simulating brightness temperature (BT) in these channels. Therefore, improving the accuracy of SKT in the background field is a direct way to improve the assimilation effect of these low-level channel data over land. In this study, both high-spatio-temporal-resolution automatic weather station (AWS) observation data from China in September 2021 and the AMSU-A observation data from NOAA-15/18/19 and MetOp-A were used. Based on the Advanced Research version of the Weather Research and Forecast model (WRF-ARW) and Gridpoint Statistical Interpolation (GSI) assimilation system, we first analyzed the differences in SKT between AWS observations and model simulations and then attempted to directly replace the simulated SKT with the observation data. On this basis, the differences in BT simulation effects over the land area of Southwest China before and after replacement were meticulously analyzed and compared. In addition, the impacts of SKT replacement in areas with different terrain elevations and in cloudy areas were also evaluated. The results indicate that the SKTs of background fields were generally lower than the surface observations, whereas the diurnal variation in SKT was not well simulated. After replacing the SKT of the background field with station observations, the BT differences between the observation and background (O–B, observation minus background) were remarkably reduced, especially for channels 3–5 and 15 of the AMSU-A. The volume of data passing the GSI quality control significantly increased, and the standard deviation of O–B decreased. Further analysis showed that the improvement effect was better in areas at an elevation above 1600 m. Moreover, introducing SKT observations leads to a significant and stable improvement over BT simulations in cloudy areas over land. Full article

A unique End-of-Life (EOL) Deep Space View Test (DSVT) was performed on 27 November 2021 for the Advanced Microwave Sounding Unit-A (AMSU-A) and the Microwave Humidity Sounder (MHS) onboard the first EUMETSAT MetOp-A satellite in the deorbiting process. The purpose of this test is to recalibrate the antenna sidelobe, to derive antenna emission, and to quantify the in-orbit asymmetric scan biases of AMSU-A and MHS to, ultimately, improve Near Real-Time (NRT) products for MetOp-B and -C and the entire Fundamental Climate Data Records (FCDR). In this study, MetOp-A AMSU-A and MHS EOL DSVT data on 27 November 2021 have been analyzed. The deep space scene antenna temperatures were first applied for the antenna pattern correction; then, the antenna reflector channel emissivity values were derived from the corrected temperatures. For the MHS, the observed scan-angle-dependent brightness temperatures (BTs) for all channels were well behaved after the antenna pattern correction, except for channel 1. The derived antenna reflector emissivity values from this test are 0.0016, 0.0036, 0.0036, and 0.0019 for channels 1, 3, 4, and 5, respectively. For AMSU-A, the deep space view counts were not homogeneous during the test period, exhibiting large variations in the along-track and cross-track directions, mainly due to the instrument temperature’s rapid change during the test period. The large relative noise in the deep space view observations negatively impacted the data quality and limits the value of this test. The large relative noise may contribute to the different emissivity values derived from the same frequency for channels 9 to 14. We also found unexpected scan-angle-dependent BT after antenna pattern correction for quasi-vertical (QV) channels 1 and 2 when compared to the emission model. Further investigation using a simulation confirmed that channels 1 and 2 are QV channels, as designed. Full article

Since 2002, China has launched four Haiyang-1 (HY-1) satellites equipped with the Chinese Ocean Color and Temperature Scanner (COCTS), which can observe the sea surface temperature (SST). The planned new generation ocean color observation satellites also carry a sensor for observing the SST represented by the payload in this paper. We analyze the spectral brightness temperature (BT) difference between the payload and the Moderate Resolution Imaging Spectroradiometer (MODIS) onboard Terra for the thermal infrared channels (11 and 12 µm) based on atmospheric radiative transfer simulation. The bias and standard deviation (SD) of spectral BT difference for the 11 µm channel are −0.12 K and 0.15 K, respectively, and those for the 12 µm channel are −0.10 K and 0.03 K, respectively. When the total column water vapor (TCWV) decreases from the oceans near the equator to high-latitude oceans, the spectral BT difference of the 11 µm channel varies from a positive deviation to a negative deviation, and that of the 12 µm channel basically remains stable. By correcting the MODIS BT observation using the spectral BT differences, we produce the simulated BT data for the thermal infrared channels of the payload, and then validate it using the Infrared Atmospheric Sounding Interferometer (IASI) carried on METOP-B. The validation results show that the bias of BT difference between the payload and IASI is −0.22 K for the 11 µm channel, while it is −0.05 K for the 12 µm channel. The SD of both channels is 0.13 K. In this study, we provide the simulated BT dataset for the 11 and 12 µm channels of a payload for the retrieval of SST. The simulated BT dataset corrected may be used to develop SST-retrieval algorithms. Full article

This study aims to explore the joint usage of multisource scatterometer measurements in polar sea water and ice discrimination. All radar backscatter measurements from current operating satellite scatterometers are considered, including the C-band ASCAT scatterometer on board the MetOp series satellites, the Ku-band scatterometer on board the HY-2B satellite (HSCAT), and the Ku-band scatterometer on board the CFOSAT satellite (CSCAT). By performing seven experiments that use the same support vector machine (SVM) classifier method but with different input data, we find that the SVM model with all available HSCAT, CSCAT, and ASCAT scatterometer data as inputs gives the best performance. In addition to the SVM outputs, we employ the image erosion/dilation techniques and area growth method to reduce misclassifications of sea water and ice. The sea ice extent obtained in this study shows a good agreement with the National Snow and Ice Data Center (NSIDC) sea ice concentration data from the years 2019 to 2021. More specifically, the sea ice areas are closer to the sea ice areas calculated using 15% as the threshold for NSIDC sea ice concentration data in both Arctic and Antarctic. The sea ice edges acquired by the multisource scatterometer show a close correlation with sea ice edges from the Sentinel-1 Synthetic Aperture Radar (SAR) images. In addition, we found that the coverage of multisource scatterometer data in a half-day is usually above 97%, and more importantly, the sea ice areas obtained on the basis of half-day and daily multisource scatterometer data are very close to each other. The presented work can serve as guidance on the usage of all available scatterometer measurements in sea ice monitoring. Full article

The newest and upcoming geostationary passive imagers have thermal infrared channels comparable to those of more established instruments, but their spectral response functions still differ significantly. Therefore, retrievals developed for a certain type of radiometer cannot simply be applied to another imager. Here, a set of spectral band adjustment factors is determined for MSG/SEVIRI, Himawari-8/AHI, and MTG1/FCI from a training dataset based on MetOp/IASI hyperspectral observations. These correction functions allow to turn the observation of one sensor into an analogue observation of another sensor. This way, the same satellite retrieval—that has been usually developed for a specific instrument with a specific spectral response function—can be applied to produce long time series that go beyond one single satellite/satellite series or to cover the entire geostationary ring in a consistent way. It is shown that the mean uncorrected brightness temperature differences between corresponding channels of two imagers can be >1 K, in particular for the channels centered around 13.4 μm in the carbon dioxide absorption band and even when comparing different imager realizations of the same series, such as the four SEVIRI sensors aboard MSG1 to MSG4. The spectral band adjustment factors can remove the bias and even reduce the standard deviation in the brightness temperature difference by more than 80%, with the effect being dependent on the spectral channel and the complexity of the correction function. Further tests include the application of the spectral band adjustment factors in combination with (a) a volcanic ash cloud retrieval to Himawari-8/AHI observations of the Raikoke eruption 2019 and a comparison to an ICON-ART model simulation, and (b) an ice cloud retrieval to simulated MTG1/FCI test data with the outcome compared to the retrieval results using real MSG3/SEVIRI measurements for the same scene. Full article

The Chinese new marine dynamic environment satellite HY-2D was launched on 19 May 2021, carrying a Ku-band scatterometer (named HSCAT-D). In this study, wind products observed by the HSCAT-D were validated by comparing with wind data from the U.S. National Data Buoy Center (NDBC) buoys and European Centre for Medium-Range Weather Forecasts (ECMWF) model. The statistical results show that the HSCAT-D winds have a good agreement with the buoys’ wind measurements: in comparison with buoy winds, the wind speed standard deviation (STD) and root-mean-squared errors (RMSE) of direction were 0.78 m/s and 14.10°, respectively. Other scatterometers’ wind data are also employed for comparisons, including the HY-2B scatterometer (HSCAT-B), HY-2C scatterometer (HSCAT-C), and MetOp-B scatterometer (ASCAT-B) winds. The statistical results indicate that errors for HSCAT-D winds are smaller than HSCAT-C but a little bit larger than HSCAT-B. The spectral analysis shows that the HSCAT-D wind products contain less small-scale information than ASCAT-B. Moreover, the Extended Triple Collocation (ETC) results show that the HSCAT-D wind product is of good quality and well-calibrated. We believe that the HSCAT-D wind products will be helpful for the scientific community, as shown by the encouraging validation results. Full article

Clostridioides difficile infection (CDI) is an urgent threat and unmet medical need. The current treatments for CDI are not enough to fight the burden of CDI and recurrent CDI (r-CDI). This review aims to highlight the future drugs for CDI and their related patented applications. The non-patent literature was collected from PubMed and various authentic websites of pharmaceutical industries. The patent literature was collected from free patent databases. Many possible drugs of the future for CDI, with diverse mechanisms of action, are in development in the form of microbiota-modulating agents (e.g., ADS024, CP101, RBX2660, RBX7455, SYN-004, SER-109, VE303, DAV132, MET-2, and BB128), small molecules (e.g., ridinilazole, ibezapolstat, CRS3123, DNV3837, MGB-BP-3, alanyl-L-glutamine, and TNP-2198), antibodies (e.g., IM-01 and LMN-201), and non-toxic strains of CD (e.g., NTCD-M3). The development of some therapeutic agents (e.g., DS-2969b, OPS-2071, cadazolid, misoprostol, ramoplanin, KB109, LFF571, and Ramizol) stopped due to failed clinical trials or unknown reasons. The patent literature reveals some important inventions for the existing treatments of CDI and supports the possibility of developing more and better CDI-treatment-based inventions, including patient-compliant dosage forms, targeted drug delivery, drug combinations of anti-CDI drugs possessing diverse mechanisms of action, probiotic and enzymatic supplements, and vaccines. The current pipeline of anti-CDI medications appears promising. However, it will be fascinating to see how many of the cited are successful in gaining approval from drug regulators such as the US FDA and becoming medicines for CDI and r-CDI. Full article

To understand the activity of gravity waves (GWs) over the Tibetan Plateau (TP) is of great significance for improving global climate models. Considering that the lower stratosphere is the main level of GWs activity, this paper first established a 14-year 2° × 2° longitude–latitude monthly mean GWs model in the lower stratosphere (18~20 km) of the TP by combining post-processed dry temperature profiles provided by the multi-Global Navigation Satellite System (GNSS) radio occultation (RO) missions: The Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) and the Meteorological Operational (METOP) series polar-orbiting meteorological satellites (METOP-A, METOP-B, and METOP-C) from August 2006 to September 2020. Based on this model, this paper analyzed the characteristics of GWs activity around TP and the effects of topography, background wind, and zonal wind on GWs activity and summarized the general process of topographic wave excitation and upward propagation around TP. The spatial distribution of the lower stratospheric GW Ep is highly correlated with the spatial distribution of background wind and the topography of TP during GWs excitation. The GW Ep is obviously filtered by the zero-speed wind. The change in GW Ep is strongly correlated with the change in topography. These phenomena indicate that the GWs of TP are mainly topographic waves. Moreover, the lower stratospheric GW Ep of TP shows that periodic changes are mainly affected by the periodic background wind, and the GW Ep value is larger in February and smaller in August. The large GW Ep in the lower stratosphere of TP is not only related to the GWs strongly generated by the interaction between the strong background wind and the large elevation or large topographic changes but also related to the strong zonal westerly winds that promote the propagation of GWs upward. Multivariable linear regression models were used to reconstruct the lower stratospheric GW Ep over TP based on the background wind and the zonal wind and a goodness of fit of 81.1% was achieved. It indicates that the GW Ep is dominated by the topographic wave over TP in the lower stratosphere and the background wind has a greater influence on the GWs than the zonal wind. Full article