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Search Results (283)

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Keywords = bioinspired technology

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24 pages, 1442 KB  
Article
Machine Learning–Driven Optimization of Photovoltaic Systems on Uneven Terrain for Sustainable Energy Development
by Luis Angel Iturralde Carrera, Carlos D. Constantino-Robles, Omar Rodríguez-Abreo, Carlos Fuentes-Silva, Gabriel Alejandro Cruz Reyes, Araceli Zapatero-Gutiérrez, Yoisdel Castillo Alvarez and Juvenal Rodríguez-Reséndiz
AI 2026, 7(2), 55; https://doi.org/10.3390/ai7020055 - 2 Feb 2026
Viewed by 1807
Abstract
This study presents an AI-driven computational framework for optimizing the orientation and spatial deployment of photovoltaic (PV) systems installed on uneven terrain, with the objective of enhancing energy efficiency and supporting sustainable energy development. The proposed methodology integrates PVsyst-based numerical simulations with statistical [...] Read more.
This study presents an AI-driven computational framework for optimizing the orientation and spatial deployment of photovoltaic (PV) systems installed on uneven terrain, with the objective of enhancing energy efficiency and supporting sustainable energy development. The proposed methodology integrates PVsyst-based numerical simulations with statistical modeling and bio-inspired heuristic optimization algorithms, forming a hybrid machine learning–assisted decision-making approach. A heuristic–parametric optimization strategy was employed to evaluate multiple tilt and azimuth configurations, aiming to maximize specific energy yield and overall system performance, expressed through the performance ratio (PR). The model was validated using site-specific climatic data from Veracruz, Mexico, and identified an optimal azimuth orientation of approximately 267.3°, corresponding to an estimated PR of 0.8318. The results highlight the critical influence of azimuth orientation on photovoltaic efficiency and demonstrate strong consistency between simulation outputs, statistical analysis, and intelligent optimization results. From an industrial perspective, the proposed framework reduces planning uncertainty and energy losses associated with suboptimal configurations, enabling more reliable and cost-effective photovoltaic system design, particularly for installations on uneven terrain. Moreover, the methodology significantly reduces planning time and potential installation costs by eliminating the need for preliminary physical testing, offering a scalable and reproducible AI-assisted tool that can contribute to lower levelized energy costs, enhanced system reliability, and more efficient deployment of photovoltaic technologies in the renewable energy industry. Future work will extend the model toward a multivariable machine learning framework incorporating tilt angle, climatic variability, and photovoltaic technology type, further strengthening its applicability in real-world environments and its contribution to Sustainable Development Goal 7: affordable and clean energy. Full article
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32 pages, 7073 KB  
Article
Crack Contour Modeling Based on a Metaheuristic Algorithm and Micro-Laser Line Projection
by J. Apolinar Muñoz Rodríguez
Biomimetics 2026, 11(2), 102; https://doi.org/10.3390/biomimetics11020102 - 2 Feb 2026
Viewed by 254
Abstract
Currently, bio-inspired metaheuristic algorithms play an important role in computer vision for assessing surface cracks. Also, manufacturing industries need non-destructive technologies based on biomimetics theory for characterizing micro-crack contours to determine surface quality. In this way, it is necessary to develop bio-inspired algorithms [...] Read more.
Currently, bio-inspired metaheuristic algorithms play an important role in computer vision for assessing surface cracks. Also, manufacturing industries need non-destructive technologies based on biomimetics theory for characterizing micro-crack contours to determine surface quality. In this way, it is necessary to develop bio-inspired algorithms to construct crack contour models for determining crack regions through an optical microscope system. In this study, a metaheuristic genetic algorithm is implemented to build crack contour models by means of Bezier functions and crack coordinates. The contour modeling is performed by a microscope vision system based on micro-laser line scanning, which provides the crack coordinates through a broken laser line in the crack region. Thus, the metaheuristic algorithm builds the crack contour model by fitting the Bezier functions toward the crack topography. At this stage, an objective function moves the Bezier functions toward the crack topography via control points. The proposed technique provides micro-scale crack contours with a relative error smaller than 2%. Thus, the proposed crack contour modeling enhances the traditional crack contour inspection based on microscope image processing. This contribution is supported by a comparison between the proposed technique and the crack characterization performed via conventional image processing algorithms. Full article
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43 pages, 6661 KB  
Systematic Review
Privacy and Security in Health Big Data: A NIST-Guided Systematic Review of Technologies, Challenges, and Future Directions
by Siyuan Zhang and Manmeet Mahinderjit Singh
Information 2026, 17(2), 148; https://doi.org/10.3390/info17020148 - 2 Feb 2026
Viewed by 215
Abstract
The rapid expansion of health big data, encompassing genomic profiles and wearable device telemetry, has significantly escalated personal privacy risks. This systematic literature review (SLR) synthesizes 86 peer-reviewed studies (2014–2025) through the dual lens of the NIST Cybersecurity and Privacy Frameworks to evaluate [...] Read more.
The rapid expansion of health big data, encompassing genomic profiles and wearable device telemetry, has significantly escalated personal privacy risks. This systematic literature review (SLR) synthesizes 86 peer-reviewed studies (2014–2025) through the dual lens of the NIST Cybersecurity and Privacy Frameworks to evaluate emerging risks, mitigation technologies, and regulatory landscapes. Our analysis identifies unauthorized access as the predominant threat, while blockchain-based solutions comprise 22.1% of proposed interventions. However, a comparative evaluation reveals critical performance trade-offs: differential privacy mechanisms incur a 15–35% utility loss, whereas blockchain implementations impose a 40–50% computational overhead. Furthermore, an assessment of major regulatory frameworks (GDPR, HIPAA, PIPL, and emerging regional laws in Sub-Saharan Africa) elucidates significant cross-jurisdictional conflicts. To address these challenges, we propose the Bio-inspired Adaptive Healthcare Privacy (BAHP) framework, validated through retrospective case study analysis, offering a dynamic approach to securing sensitive health ecosystems. Full article
(This article belongs to the Special Issue Digital Privacy and Security, 3rd Edition)
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31 pages, 4343 KB  
Systematic Review
Vehicle Aerodynamic Noise: A Systematic Review of Mechanisms, Simulation Methods, and Bio-Inspired Mitigation Strategies
by Tao Zou, Yifeng Fu and Pan Cao
Biomimetics 2026, 11(2), 99; https://doi.org/10.3390/biomimetics11020099 - 2 Feb 2026
Viewed by 381
Abstract
With the electrification of automotive powertrains, aerodynamic noise has emerged as the primary factor affecting vehicle comfort. This systematic review, adhering to PRISMA 2020 guidelines, bridges the gap between biological fluid mechanics and automotive engineering by synthesizing recent advances in aerodynamic mechanisms and [...] Read more.
With the electrification of automotive powertrains, aerodynamic noise has emerged as the primary factor affecting vehicle comfort. This systematic review, adhering to PRISMA 2020 guidelines, bridges the gap between biological fluid mechanics and automotive engineering by synthesizing recent advances in aerodynamic mechanisms and bionic control strategies. Based on a comprehensive search of Web of Science, ScienceDirect, SAE Mobilus, and Google Scholar for the literature published between 2016 and 2025, 90 eligible studies were analyzed to provide a rigorous evidence-based synthesis. The review details complex flow phenomena, such as turbulent separation and vortex shedding across key regions like A-pillars and mirrors, drawing parallels to bio-inspired fluid–structure interactions. Numerical prediction methods, including large eddy simulation (LES), detached eddy simulation (DES), and lattice boltzmann method (LBM), are critically examined for their efficacy in resolving both conventional and bionic flow structures. A significant focus is placed on bio-inspired mitigation technologies, where quantitative findings demonstrate substantial noise suppression: specifically, the reviewed data shows that bionic riblet surfaces on tires can reduce noise levels by up to 5.18 dB, while beetle-head-inspired protuberances on exterior mirrors can achieve reductions of up to 10 dB. Finally, this work suggests future research directions in integrated fluid–acoustic–structural simulation frameworks and self-adaptive bionic systems, providing a robust reference for developing high-performance, low-noise vehicles inspired by natural organisms. Full article
(This article belongs to the Special Issue Advances in Computational Methods for Biomechanics and Biomimetics)
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70 pages, 1137 KB  
Review
A Review of Artificial Intelligence Techniques for Low-Carbon Energy Integration and Optimization in Smart Grids and Smart Homes
by Omosalewa O. Olagundoye, Olusola Bamisile, Chukwuebuka Joseph Ejiyi, Oluwatoyosi Bamisile, Ting Ni and Vincent Onyango
Processes 2026, 14(3), 464; https://doi.org/10.3390/pr14030464 - 28 Jan 2026
Viewed by 297
Abstract
The growing demand for electricity in residential sectors and the global need to decarbonize power systems are accelerating the transformation toward smart and sustainable energy networks. Smart homes and smart grids, integrating renewable generation, energy storage, and intelligent control systems, represent a crucial [...] Read more.
The growing demand for electricity in residential sectors and the global need to decarbonize power systems are accelerating the transformation toward smart and sustainable energy networks. Smart homes and smart grids, integrating renewable generation, energy storage, and intelligent control systems, represent a crucial step toward achieving energy efficiency and carbon neutrality. However, ensuring real-time optimization, interoperability, and sustainability across these distributed energy resources (DERs) remains a key challenge. This paper presents a comprehensive review of artificial intelligence (AI) applications for sustainable energy management and low-carbon technology integration in smart grids and smart homes. The review explores how AI-driven techniques include machine learning, deep learning, and bio-inspired optimization algorithms such as particle swarm optimization (PSO), whale optimization algorithm (WOA), and cuckoo optimization algorithm (COA) enhance forecasting, adaptive scheduling, and real-time energy optimization. These techniques have shown significant potential in improving demand-side management, dynamic load balancing, and renewable energy utilization efficiency. Moreover, AI-based home energy management systems (HEMSs) enable predictive control and seamless coordination between grid operations and distributed generation. This review also discusses current barriers, including data heterogeneity, computational overhead, and the lack of standardized integration frameworks. Future directions highlight the need for lightweight, scalable, and explainable AI models that support decentralized decision-making in cyber-physical energy systems. Overall, this paper emphasizes the transformative role of AI in enabling sustainable, flexible, and intelligent power management across smart residential and grid-level systems, supporting global energy transition goals and contributing to the realization of carbon-neutral communities. Full article
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22 pages, 8373 KB  
Article
Real-Time Automated Ergonomic Monitoring: A Bio-Inspired System Using 3D Computer Vision
by Gabriel Andrés Zamorano Núñez, Nicolás Norambuena, Isabel Cuevas Quezada, José Luis Valín Rivera, Javier Narea Olmos and Cristóbal Galleguillos Ketterer
Biomimetics 2026, 11(2), 88; https://doi.org/10.3390/biomimetics11020088 - 26 Jan 2026
Viewed by 328
Abstract
Work-related musculoskeletal disorders (MSDs) remain a global occupational health priority, with recognized limitations in current point-in-time assessment methodologies. This research extends prior computer vision ergonomic assessment approaches by implementing biological proprioceptive feedback principles into a continuous, real-time monitoring system. Unlike traditional periodic ergonomic [...] Read more.
Work-related musculoskeletal disorders (MSDs) remain a global occupational health priority, with recognized limitations in current point-in-time assessment methodologies. This research extends prior computer vision ergonomic assessment approaches by implementing biological proprioceptive feedback principles into a continuous, real-time monitoring system. Unlike traditional periodic ergonomic evaluation methods such as “Rapid Upper Limb Assessment” (RULA), our bio-inspired system translates natural proprioceptive mechanisms—which enable continuous postural monitoring through spinal feedback loops operating at 50–150 ms latencies—into automated assessment technology. The system integrates (1) markerless 3D pose estimation via MediaPipe Holistic (33 anatomical landmarks at 30 FPS), (2) depth validation via Orbbec Femto Mega RGB-D camera (640 × 576 resolution, Time-of-Flight sensor), and (3) proprioceptive-inspired alert architecture. Experimental validation with 40 adult participants (age 18–25, n = 26 female, n = 14 male) performing standardized load-lifting tasks (6 kg) demonstrated that 62.5% exhibited critical postural risk (RULA ≥ 5) during dynamic movement versus 7.5% at static rest, with McNemar test p<0.001 (Cohen’s h=1.22, 95% CI: 0.91–0.97). The system achieved 95% Pearson correlation between risk elevation and alert activation, with response latency of 42.1±8.3 ms. This work demonstrates technical feasibility for continuous occupational monitoring. However, long-term prospective studies are required to establish whether continuous real-time feedback reduces workplace injury incidence. The biomimetic design framework provides a systematic foundation for translating biological feedback principles into occupational health technology. Full article
(This article belongs to the Section Bioinspired Sensorics, Information Processing and Control)
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30 pages, 3807 KB  
Review
Flapping Foil-Based Propulsion and Power Generation: A Comprehensive Review
by Prabal Kandel, Jiadong Wang and Jian Deng
Biomimetics 2026, 11(2), 86; https://doi.org/10.3390/biomimetics11020086 - 25 Jan 2026
Viewed by 373
Abstract
This review synthesizes the state of the art in flapping foil technology and bridges the distinct engineering domains of bio-inspired propulsion and power generation via flow energy harvesting. This review is motivated by the observation that propulsion and power-generation studies are frequently presented [...] Read more.
This review synthesizes the state of the art in flapping foil technology and bridges the distinct engineering domains of bio-inspired propulsion and power generation via flow energy harvesting. This review is motivated by the observation that propulsion and power-generation studies are frequently presented separately, even though they share common unsteady vortex dynamics. Accordingly, we adopt a unified unsteady-aerodynamic perspective to relate propulsion and energy-extraction regimes within a common framework and to clarify their operational duality. Within this unified framework, the feathering parameter provides a theoretical delimiter between momentum transfer and kinetic energy extraction. A critical analysis of experimental foundations demonstrates that while passive structural flexibility enhances propulsive thrust via favorable wake interactions, synchronization mismatches between deformation and peak hydrodynamic loading constrain its benefits in power generation. This review extends the analysis to complex and non-homogeneous environments and identifies that density stratification fundamentally alters the hydrodynamic performance. Specifically, resonant interactions with the natural Brunt–Väisälä frequency of the fluid shift the optimal kinematic regimes. The present study also surveys computational methodologies and highlights a paradigm shift from traditional parametric sweeps to high-fidelity three-dimensional (3D) Large-Eddy Simulations (LESs) and Deep Reinforcement Learning (DRL) to resolve finite-span vortex interconnectivities. Finally, this review outlines the critical pathways for future research. To bridge the gap between computational idealization and physical reality, the findings suggest that future systems prioritize tunable stiffness mechanisms, multi-phase environmental modeling, and artificial intelligence (AI)-driven digital twin frameworks for real-time adaptation. Full article
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45 pages, 14875 KB  
Review
A New Era in Computing: A Review of Neuromorphic Computing Chip Architecture and Applications
by Guang Chen, Meng Xu, Yuying Chen, Fuge Yuan, Lanqi Qin and Jian Ren
Chips 2026, 5(1), 3; https://doi.org/10.3390/chips5010003 - 22 Jan 2026
Viewed by 522
Abstract
Neuromorphic computing, an interdisciplinary field combining neuroscience and computer science, aims to create efficient, bio-inspired systems. Different from von Neumann architectures, neuromorphic systems integrate memory and processing units to enable parallel, event-driven computation. By simulating the behavior of biological neurons and networks, these [...] Read more.
Neuromorphic computing, an interdisciplinary field combining neuroscience and computer science, aims to create efficient, bio-inspired systems. Different from von Neumann architectures, neuromorphic systems integrate memory and processing units to enable parallel, event-driven computation. By simulating the behavior of biological neurons and networks, these systems excel in tasks like pattern recognition, perception, and decision-making. Neuromorphic computing chips, which operate similarly to the human brain, offer significant potential for enhancing the performance and energy efficiency of bio-inspired algorithms. This review introduces a novel five-dimensional comparative framework—process technology, scale, power consumption, neuronal models, and architectural features—that systematically categorizes and contrasts neuromorphic implementations beyond existing surveys. We analyze notable neuromorphic chips, such as BrainScaleS, SpiNNaker, TrueNorth, and Loihi, comparing their scale, power consumption, and computational models. The paper also explores the applications of neuromorphic computing chips in artificial intelligence (AI), robotics, neuroscience, and adaptive control systems, while facing challenges related to hardware limitations, algorithms, and system scalability and integration. Full article
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56 pages, 6343 KB  
Review
Advanced 3D/4D Bioprinting of Flexible Conductive Materials for Regenerative Medicine: From Bioinspired Design to Intelligent Regeneration
by Kuikui Zhang, Lezhou Fang, Can Xu, Weiwei Zhou, Xiaoqiu Deng, Chenkun Shan, Quanling Zhang and Lijia Pan
Micro 2026, 6(1), 8; https://doi.org/10.3390/micro6010008 - 21 Jan 2026
Viewed by 275
Abstract
Regenerative medicine is increasingly leveraging the synergies between bioinspired conductive biomaterials and 3D/4D bioprinting to replicate the native electroactive and hierarchical microenvironments essential for functional tissue restoration. However, a critical gap remains in the intelligent integration of these technologies to achieve dynamic, responsive [...] Read more.
Regenerative medicine is increasingly leveraging the synergies between bioinspired conductive biomaterials and 3D/4D bioprinting to replicate the native electroactive and hierarchical microenvironments essential for functional tissue restoration. However, a critical gap remains in the intelligent integration of these technologies to achieve dynamic, responsive tissue regeneration. This review introduces a “bioinspired material–printing–function” triad framework to systematically synthesize recent advances in: (1) tunable conductive materials (polymers, carbon-based systems, metals, MXenes) designed to mimic the electrophysiological properties of native tissues; (2) advanced 3D/4D printing technologies (vat photopolymerization, extrusion, inkjet, and emerging modalities) enabling the fabrication of biomimetic architectures; and (3) functional applications in neural, cardiac, and musculoskeletal tissue engineering. We highlight how bioinspired conductive scaffolds enhance electrophysiological behaviors—emulating natural processes such as promoting axon regeneration cardiomyocyte synchronization, and osteogenic mineralization. Crucially, we identify multi-material 4D bioprinting as a transformative bioinspired approach to overcome conductivity–degradation trade-offs and enable shape-adaptive, smart scaffolds that dynamically respond to physiological cues, mirroring the adaptive nature of living tissues. This work provides the first roadmap toward intelligent electroactive regeneration, shifting the paradigm from static implants to dynamic, biomimetic bioelectronic microenvironments. Future translation will require leveraging AI-driven bioinspired design and organ-on-a-chip validation to address challenges in vascularization, biosafety, and clinical scalability. Full article
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29 pages, 6120 KB  
Article
Bionic Technology in Prosthetics: Multi-Objective Optimization of a Bioinspired Shoulder-Elbow Prosthesis with Embedded Actuation
by Jingxu Jiang, Gengbiao Chen, Xin Wang and Hongwei Yan
Biomimetics 2026, 11(1), 79; https://doi.org/10.3390/biomimetics11010079 - 19 Jan 2026
Viewed by 418
Abstract
The development of upper-limb prostheses is often hindered by limited dexterity, a restricted workspace, and bulky designs, primarily due to performance limitations in proximal joints like the shoulder and elbow, which contribute to high user abandonment rates. To overcome these challenges, this paper [...] Read more.
The development of upper-limb prostheses is often hindered by limited dexterity, a restricted workspace, and bulky designs, primarily due to performance limitations in proximal joints like the shoulder and elbow, which contribute to high user abandonment rates. To overcome these challenges, this paper presents a novel, bioinspired, and integrated prosthetic system as an advancement in bionic technology. The design incorporates a shoulder joint based on an asymmetric 3-RRR spherical parallel mechanism (SPM) with actuators embedded within the moving platform, and an elbow joint actuated by low-voltage Shape Memory Alloy (SMA) springs. The inverse kinematics of the shoulder mechanism was established, revealing the existence of up to eight configurations. We employed Multi-Objective Particle Swarm Optimization (MOPSO) to simultaneously maximize workspace coverage, enhance dexterity, and minimize joint torque. The optimized design achieves remarkable performance: (1) 85% coverage of the natural shoulder’s workspace; (2) a maximum von Mises stress of merely 3.4 MPa under a 40 N load, ensuring structural integrity; and (3) a sub-0.2 s response time for the SMA-driven elbow under low-voltage conditions (6 V) at a motion velocity of 6°/s. Both motion simulation and prototype testing validated smooth and anthropomorphic motion trajectories. This work provides a comprehensive framework for developing lightweight, high-performance prosthetic limbs, establishing a solid foundation for next-generation wearable robotics and bionic devices. Future research will focus on the integration of neural interfaces for intuitive control. Full article
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18 pages, 7628 KB  
Article
Bio-Inspired Ghost Imaging: A Self-Attention Approach for Scattering-Robust Remote Sensing
by Rehmat Iqbal, Yanfeng Song, Kiran Zahoor, Loulou Deng, Dapeng Tian, Yutang Wang, Peng Wang and Jie Cao
Biomimetics 2026, 11(1), 53; https://doi.org/10.3390/biomimetics11010053 - 8 Jan 2026
Viewed by 397
Abstract
Ghost imaging (GI) offers a robust framework for remote sensing under degraded visibility conditions. However, atmospheric scattering in phenomena such as fog introduces significant noise and signal attenuation, thereby limiting its efficacy. Inspired by the selective attention mechanisms of biological visual systems, this [...] Read more.
Ghost imaging (GI) offers a robust framework for remote sensing under degraded visibility conditions. However, atmospheric scattering in phenomena such as fog introduces significant noise and signal attenuation, thereby limiting its efficacy. Inspired by the selective attention mechanisms of biological visual systems, this study introduces a novel deep learning (DL) architecture that embeds a self-attention mechanism to enhance GI reconstruction in foggy environments. The proposed approach mimics neural processes by modeling both local and global dependencies within one-dimensional bucket measurements, enabling superior recovery of image details and structural coherence even at reduced sampling rates. Extensive simulations on the Modified National Institute of Standards and Technology (MNIST) and a custom Human-Horse dataset demonstrate that our bio-inspired model outperforms conventional GI and convolutional neural network-based methods. Specifically, it achieves Peak Signal-to-Noise Ratio (PSNR) values between 24.5–25.5 dB/m and Structural Similarity Index Measure (SSIM) values of approximately 0.8 under high scattering conditions (β  3.0 dB/m) and moderate sampling ratios (N  50%). A comparative analysis confirms the critical role of the self-attention module, providing high-quality image reconstruction over baseline techniques. The model also maintains computational efficiency, with inference times under 0.12 s, supporting real-time applications. This work establishes a new benchmark for bio-inspired computational imaging, with significant potential for environmental monitoring, autonomous navigation and defense systems operating in adverse weather. Full article
(This article belongs to the Special Issue Bionic Vision Applications and Validation)
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18 pages, 4211 KB  
Article
Fabrication and Drag Reduction Performance of Flexible Bio-Inspired Micro-Dimple Film
by Yini Cai, Yanjun Lu, Haopeng Gan, Yan Yu, Xiaoshuang Rao and Weijie Gong
Micromachines 2026, 17(1), 85; https://doi.org/10.3390/mi17010085 - 8 Jan 2026
Viewed by 363
Abstract
The flexible micro-structured surface found in biological skins exhibits remarkable drag reduction properties, inspiring applications in the aerospace industry, underwater exploration, and pipeline transportation. To address the challenge of efficiently replicating such structures, this study presents a composite flexible polymer film with a [...] Read more.
The flexible micro-structured surface found in biological skins exhibits remarkable drag reduction properties, inspiring applications in the aerospace industry, underwater exploration, and pipeline transportation. To address the challenge of efficiently replicating such structures, this study presents a composite flexible polymer film with a bio-inspired micro-dimple array, fabricated via an integrated process of precision milling, polishing, and micro-injection molding using thermoplastic polyurethane (TPU). We systematically investigated the influence of key injection parameters on the shape accuracy and surface quality of the film. The experimental results show that polishing technology can significantly reduce mold core surface roughness, thereby enhancing film replication accuracy. Among the parameters, melt temperature and holding time exerted the most significant effects on shape precision PV and bottom roughness Ra, while injection speed showed the least influence. Under optimized conditions of a melt temperature of 180 °C, injection speed of 60 mm/s, holding pressure of 7 MPa, and holding time of 13 s, the film achieved a micro-structure shape accuracy of 13.502 μm and bottom roughness of 0.033 μm. Numerical simulation predicted a maximum drag reduction rate of 10.26%, attributable to vortex cushion effects within the dimples. This performance was experimentally validated in a flow velocity range of 0.6–2 m/s, with the discrepancy between simulated and measured drag reduction kept within 5%, demonstrating the efficacy of the proposed manufacturing route for flexible bio-inspired drag reduction film. Full article
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23 pages, 4693 KB  
Review
Research Advances in Bionic Cell Membrane-Mediated Nanodrug Delivery Systems for the Treatment of Periodontitis with Osteoporosis
by Xinyuan Ma, Dingxin Xue, Siqi Li, Guangxin Yuan and Yufeng Ma
Int. J. Mol. Sci. 2026, 27(2), 583; https://doi.org/10.3390/ijms27020583 - 6 Jan 2026
Viewed by 530
Abstract
With the intensification of global population aging, the co-morbidity rate of periodontitis and osteoporosis has significantly increased. The two are pathologically intertwined, forming a vicious cycle characterized by bone immunoregulatory dysfunction in the periodontal microenvironment, abnormal accumulation of reactive oxygen species (ROS), and [...] Read more.
With the intensification of global population aging, the co-morbidity rate of periodontitis and osteoporosis has significantly increased. The two are pathologically intertwined, forming a vicious cycle characterized by bone immunoregulatory dysfunction in the periodontal microenvironment, abnormal accumulation of reactive oxygen species (ROS), and disruption of bone homeostasis. Conventional mechanical debridement and anti-infective therapy can reduce the pathogen load, but in some patients, it remains challenging to achieve long-term stable control of inflammation and bone resorption. Furthermore, abnormal bone metabolism in the context of osteoporosis further weakens the osteogenic response during the repair phase, limiting the efficacy of these treatments. Bioinspired cell membrane-coated nanoparticles (CMNPs) have emerged as an innovative technological platform. By mimicking the biointerface properties of source cells—such as red blood cells, platelets, white blood cells, stem cells, and their exosomes—CMNPs enable targeted drug delivery, prolonged circulation within the body, and intelligent responses to pathological microenvironments. This review systematically explores how biomimetic design leverages the advantages of natural biological membranes to address challenges in therapeutic site enrichment and tissue penetration, in vivo circulation stability and effective exposure maintenance, and oxidative stress and immune microenvironment intervention, as well as functional regeneration supported by osteogenesis and angiogenesis. Additionally, we conducted an in-depth analysis of the key challenges encountered in translating preclinical research findings into clinical applications within this field, including issues such as the feasibility of large-scale production, batch-to-batch consistency, and long-term biosafety. This review lays a solid theoretical foundation for advancing the clinical translation of synergistic treatment strategies for periodontitis with osteoporosis and provides a clear research and development pathway. Full article
(This article belongs to the Special Issue Nanoparticles in Molecular Pharmaceutics)
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33 pages, 2694 KB  
Review
Biomimetic Strategies for Bone Regeneration: Smart Scaffolds and Multiscale Cues
by Sheikh Md Mosharof Hossen, Md Abdul Khaleque, Min-Su Lim, Jin-Kyu Kang, Do-Kyun Kim, Hwan-Hee Lee and Young-Yul Kim
Biomimetics 2026, 11(1), 12; https://doi.org/10.3390/biomimetics11010012 - 27 Dec 2025
Cited by 1 | Viewed by 1082
Abstract
Bone regeneration remains difficult due to the complex bone microenvironment and the limited healing capacity of large defects. Biomimetic strategies offer promising solutions by using advanced 3D scaffolds guided by natural tissue cues. Recent advances in additive manufacturing, nanotechnology, and tissue engineering now [...] Read more.
Bone regeneration remains difficult due to the complex bone microenvironment and the limited healing capacity of large defects. Biomimetic strategies offer promising solutions by using advanced 3D scaffolds guided by natural tissue cues. Recent advances in additive manufacturing, nanotechnology, and tissue engineering now allow the fabrication of hierarchical scaffolds that closely mimic native bone. Smart scaffold systems combine materials with biochemical and mechanical signals. These features improve vascularization, enhance tissue integration, and support better regenerative outcomes. Bio-inspired materials also help connect inert implants with living tissues by promoting vascular network formation and improving cell communication. Multiscale design approaches recreate bone nano- to macro-level structure and support both osteogenic activity and immune regulation. Intelligent and adaptive scaffolds are being developed to respond to physiological changes and enable personalized bone repair. This review discusses the current landscape of biomimetic scaffold design, fabrication techniques, material strategies, biological mechanisms, and translational considerations shaping next-generation bone regeneration technologies. Future directions focus on sustainable, clinically translatable biomimetic systems that can integrate with digital health tools for improved treatment planning. Full article
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54 pages, 1952 KB  
Review
Removal of Kerosene from Wastewater: Current Trends and Emerging Perspectives for Environmental Remediation
by Noureddine El Messaoudi, Youssef Miyah, Jordana Georgin, Dison S. P. Franco, Andrew Nosakhare Amenaghawon, Bambang Sardi, Ashraf M. Al-Msiedeen and Maria Harja
Sustainability 2026, 18(1), 277; https://doi.org/10.3390/su18010277 - 26 Dec 2025
Viewed by 490
Abstract
Kerosene spills from industrial processes, oil spills, and improper waste disposal can pose significant risks to human health and the environment due to their toxicity, persistence, and bioaccumulation. This review will provide an integrated overview of kerosene removal from wastewater, drawing on the [...] Read more.
Kerosene spills from industrial processes, oil spills, and improper waste disposal can pose significant risks to human health and the environment due to their toxicity, persistence, and bioaccumulation. This review will provide an integrated overview of kerosene removal from wastewater, drawing on the most recent developments, material design recommendations, scalability concepts, and possible future directions. Conventional treatment processes such as adsorption, membrane separation, advanced oxidation processes (AOPs), and biodegradation are assessed critically in light of performance, scalability, and environmental applicability. The review focuses on the synthesis of novel materials such as nanocomposites, porous materials, functionalized polymers, and bio-inspired materials based on designs of high selectivity, reusability, and improved degradation/separation efficiencies. In addition, some emerging trends are highlighted with the review, including the use of cost–effective and sustainable materials, and the circular economy. Given the substantial knowledge- and problem-gap issues, the goal of this research is to provide pathways for researchers to develop efficient, sustainable, and scalable kerosene–contaminated wastewater treatment technologies to assist with water resourcing and conservation. Full article
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