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16 Results Found

  • Review
  • Open Access
25 Citations
7,620 Views
33 Pages

Mechanisms Applied by Protein Inhibitors to Inhibit Cysteine Proteases

  • Livija Tušar,
  • Aleksandra Usenik,
  • Boris Turk and
  • Dušan Turk

Protein inhibitors of proteases are an important tool of nature to regulate and control proteolysis in living organisms under physiological and pathological conditions. In this review, we analyzed the mechanisms of inhibition of cysteine proteases on...

  • Review
  • Open Access
1 Citations
5,240 Views
12 Pages

Using Spectral Flow Cytometry for CAR T-Cell Clinical Trials: Game Changing Technologies Enabling Novel Therapies

  • Thomas C. Beadnell,
  • Susmita Jasti,
  • Ruqi Wang,
  • Bruce H. Davis and
  • Virginia Litwin

24 September 2024

Monitoring chimeric antigen redirected (CAR) T-cells post-infusion in clinical trials is a specialized application of flow cytometry. Unlike the CAR T-cell monitoring for individual patients conducted in clinical laboratories, the data generated duri...

  • Review
  • Open Access
4 Citations
1,309 Views
22 Pages

A review of the literature on polymorphic transformations by milling on pharmaceutical materials was carried out. The available information on 18 pharmaceutical materials was compiled. In particular, when data are available, the starting and final cr...

  • Article
  • Open Access
29 Citations
8,621 Views
28 Pages

Estimation of Grey-Box Dynamic Model of 2-DOF Pneumatic Actuator Robotic Arm Using Gravity Tests

  • Monika Trojanová,
  • Tomáš Čakurda,
  • Alexander Hošovský and
  • Tibor Krenický

14 May 2021

This article describes the dynamics of a manipulator with two degrees of freedom, while the dynamic model of the manipulator’s arm is derived using Lagrangian formalism, which considers the difference between the kinetic and potential energy of the s...

  • Article
  • Open Access
5 Citations
2,551 Views
32 Pages

22 March 2024

Secondary reactions in radical polymerization pose a challenge when creating kinetic models for predicting polymer structures. Despite the high impact of these reactions in the polymer structure, their effects are difficult to isolate and measure to...

  • Review
  • Open Access
24 Citations
4,186 Views
19 Pages

22 January 2021

Alkaline (pH > 8.5) lakes have been common features of Earth’s surface environments throughout its history and are currently among the most biologically productive environments on the planet. The chemistry of alkaline lakes favors the deposition o...

  • Review
  • Open Access
8 Citations
5,227 Views
10 Pages

Literature reports superior performance when focusing one’s attention during a movement on environmental effects of that movement (external focus, EF) compared to focusing on the moving body (internal focus, IF). Nevertheless, IF instructions s...

  • Article
  • Open Access
6 Citations
3,370 Views
28 Pages

Mechanism, Kinetics and Thermodynamics of Decomposition for High Energy Derivatives of [1,2,4]Triazolo[4,3-b][1,2,4,5]tetrazine

  • Aleksandr V. Stankevich,
  • Svetlana G. Tolshchina,
  • Anna V. Korotina,
  • Gennady L. Rusinov,
  • Irina V. Chemagina and
  • Valery N. Charushin

17 October 2022

This paper presents the data of research studies on the mechanisms, kinetics and thermodynamics of decomposition of three high-energy compounds: [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine-3,6-diamine (TTDA), 3-amino-6-hydrazino[1,2,4]triazolo[4,3-b][1,...

  • Article
  • Open Access
16 Citations
4,193 Views
23 Pages

Homogeneous Freezing of Water Using Microfluidics

  • Mark D. Tarn,
  • Sebastien N. F. Sikora,
  • Grace C. E. Porter,
  • Jung-uk Shim and
  • Benjamin J. Murray

23 February 2021

The homogeneous freezing of water is important in the formation of ice in clouds, but there remains a great deal of variability in the representation of the homogeneous freezing of water in the literature. The development of new instrumentation, such...

  • Review
  • Open Access
66 Citations
12,572 Views
39 Pages

23 November 2012

Flavoprotein monooxygenases (FPMOs) exhibit an array of mechanistic solutions to a common chemical objective; the monooxygenation of a target substrate. Each FPMO efficiently couples reduction of a flavin cofactor by NAD(P)H to oxygenation of the tar...

  • Article
  • Open Access
5 Citations
3,035 Views
31 Pages

23 January 2024

The thermodynamic and kinetic contributions to the over-extraction of extractables by nonpolar organic solvents relative to biological lipids in exhaustive and exaggerated extractions of medical devices are studied based on the Abraham solvation mode...

  • Article
  • Open Access
19 Citations
4,819 Views
15 Pages

In common irrigation systems, sprinklers are mounted with circular nozzles, but innovative noncircular nozzles can save water and energy by improving fragmentation in a low–intermediate pressure irrigation system. In order to investigate the ef...

  • Review
  • Open Access
8 Citations
5,876 Views
12 Pages

Staphylococcus schweitzeri—An Emerging One Health Pathogen?

  • Chantal Akoua-Koffi,
  • Adèle Kacou N’Douba,
  • Joseph Allico Djaman,
  • Mathias Herrmann,
  • Frieder Schaumburg and
  • Silke Niemann

The Staphylococcus aureus-related complex is formed by the Staphylococcus aureus, Staphylococcus schweitzeri, Staphylococcus argenteus, Staphylococcus roterodami and Staphylococcus singaporensis. Within this complex, S. schweitzeri is the only specie...

  • Review
  • Open Access
9 Citations
3,546 Views
16 Pages

25 November 2023

The dietary inclusion of trace minerals (TMs), such as copper (Cu), manganese (Mn) and zinc (Zn), is of importance to cover the ever-evolving requirements for growth, production and reproduction in ruminants. Various sources of TMs are commercially a...

  • Article
  • Open Access
1 Citations
1,633 Views
39 Pages

23 July 2025

In recent years, the rapid development of lightweight Unmanned Aerial Vehicle (UAV) technology under 250 g has begun to challenge the validity of existing mass-based safety classifications. The commonly used 250 g threshold for defining “harmle...

  • Article
  • Open Access
1,024 Views
43 Pages

7 November 2025

This study aims to qualitatively and quantitatively assess the ability of the flow solver “reactingFoam” of the open-source OpenFOAM software v.2506 for a control-volume-based computational fluid dynamics (CFD) solver in treating the reac...