Search Results (5,387)

Cyclic dynamic loading significantly influences the dynamic mechanical properties of cemented tailings backfill (CTB). This study investigates the dynamic mechanical properties and mesoscopic characteristics of CTB under cyclic dynamic loading. Using a Split Hopkinson Pressure Bar (SHPB) system, impact tests were conducted on CTB specimens subjected to varying numbers of cyclic impacts. The dynamic peak compressive strength (DPCS), elastic modulus, energy evolution, and failure modes were analyzed. Additionally, computed tomography (CT) scanning and 3D reconstruction techniques were employed to examine the internal pore and crack distribution. Results indicate that cyclic impacts lead to a gradual reduction in DPCS and energy absorption capacity, while the elastic modulus shows strain-rate dependency. Mesostructural analysis reveals that cyclic loading promotes the initiation and propagation of microcracks. This study establishes a correlation between mesoscopic damage evolution and macroscopic mechanical degradation, providing insights into the durability and stability of CTB under repeated blasting disturbances in mining environments. Full article

Background/Objectives: The progressive life-limiting disorder Duchenne muscular dystrophy (DMD) arises from the absence of dystrophin protein at the muscle cell membrane, which leads to progressive contraction-induced damage. Despite the advancements in molecular therapies aimed at reintroducing (partially functional) dystrophin in patients, a cure for DMD remains elusive. Taurine supplements have been proposed as a potential supportive treatment for DMD, based upon encouraging results in the mouse model mdx. Methods: In a previous study, we observed improvements in skeletal muscle histology and a reduction in the expression of inflammatory markers after short-term treatment with 4.6 g taurine per kg body weight during the initial stages of the disease. In this follow-up study, we examined cell death and tissue restoration protein levels in mdx subjected to the same treatment regimen, utilizing proteome arrays, Western blotting, and immunofluorescence. Results: We report that, while the levels of apoptotic and autophagic proteins remained constant, selective and significant decrease in receptor-interacting Serine/Threonine protein kinase 1 (RIP1) levels could be observed in taurine-treated mdx compared to untreated mdx. RIP1 was immunolocalized to muscle fibers, with faint homogeneous staining in age-matched healthy controls shifting to a heterogeneous staining pattern in mdx, the latter diminishing with taurine treatment. Conclusions: Given its role as a molecular switch in cell fate decisions, the observed taurine-induced downregulation of RIP1 supports the potential beneficial effects of the osmolyte in mdx. Full article

Acute myocardial infarction (MI) is a major cardiovascular event and a leading cause of mortality worldwide. Beyond the initial ischemic injury, the inflammatory and immune responses play pivotal roles in both tissue damage and subsequent healing. While the anti-inflammatory strategies targeting neutrophil-driven injury have demonstrated potential in limiting early cardiac damage, growing evidence highlights the critical role of innate immune cells beyond the acute phase. Neutrophils, traditionally associated with tissue injury, also contribute to the resolution of inflammation and initiate key repair processes. Monocytes and macrophages follow a dynamic trajectory, transitioning from pro-inflammatory to reparative states, and play essential roles in debris clearance, angiogenesis, and scar formation. In the early inflammatory phase of acute MI, immune cells such as neutrophils and monocytes are rapidly recruited and activated. While they initially amplify inflammation through the release of pro-inflammatory mediators, their subsequent transition toward anti-inflammatory and reparative phenotypes helps limit tissue damage by clearing necrotic debris from the infarcted area and contributes to the resolution of inflammation. Accumulating evidence reveals a complex crosstalk between neutrophils and macrophages post-MI, with resident macrophages being involved in neutrophil recruitment, and neutrophil-derived signals participating in monocyte recruitment and macrophage polarization, thereby coordinating the spatial and temporal phases of cardiac repair. Understanding how neutrophil-derived mediators influence macrophage responses and whether macrophage-secreted factors reciprocally modulate neutrophil behavior opens promising pathways for developing targeted therapies to limit adverse remodeling following MI. Therefore, this review aims to (i) provide an overview of the roles of neutrophils and monocytes/macrophages in the pathophysiology of myocardial infarction, (ii) explore the mechanisms of communication, particularly via neutrophil-derived secreted factors, that influence monocyte/macrophage function and impact post-MI inflammation, repair, and remodeling, and (iii) highlight the potential therapies interfering with inflammation and neutrophil/macrophage cross-talk. Full article

As offshore wind power continues to extend into deeper waters, the operational environment has expanded from shallow to deep seas. Self-elevating and self-propelled installation vessels have been widely adopted due to their jack-up systems and self-propulsion capabilities. The structural integrity of wind turbine installation vessels is crucial to ensure successful operations, among which the strength of the jacking frame is particularly critical. This study focuses on the bracket made of E550 steel at the root of the jacking frame. Shape optimization of the bracket was performed using parametric modeling technology, resulting in a 26% reduction in peak stress and a 12% decrease in bracket mass. Following the optimization, a full-scale fatigue test targeting local fatigue hot spots of the bracket was carried out. Based on the experimental data, the fatigue S-N curve of the bracket was obtained. Finally, a fatigue assessment was conducted on the high-stress region at the toe of the bracket. The results indicate that the bracket with unequal arm lengths exhibits lower stress concentration. Fatigue cracks of the bracket initiate at the weld toe, and the fatigue strength of the E550 steel toe joint obtained from the test is superior to that of the D-curve specified in the standards. Based on the derived S–N curve, a spectral fatigue analysis was further carried out to verify the fatigue performance of the optimized bracket. The total fatigue damage of the optimized structure over a 20-year design life was calculated as 0.6, which is below the allowable limit of 1.0, demonstrating that the optimized design satisfies the fatigue safety requirements. Full article

A previous study demonstrated that spontaneous forest recovery can result in the development of functional mixed forests in post-mining areas. A critical step in this process is the establishment of climax woody species in the understory of pioneer trees. In this case study, we utilise repeated sampling to evaluate the establishment, initial survival, and growth of pedunculate oak (Quercus robur) and European beech (Fagus sylvatica) seedlings, and to newly assess Norway spruce (Picea abies) during unassisted forest recovery on a post-mining site after coal mining near Sokolov in North Bohemia. Detailed mapping of beech and oak seedlings was conducted in 2009 and 2012 (i.e., 14 and 11 years after the site was reclaimed). Now, we have resurveyed these seedlings, which has allowed us to evaluate their survival and growth. We have also mapped spruce seedlings and estimated their age from annual branch whorls. In the original study, most seedlings were found on the northern site near the edge of the post-mining area and the surrounding landscape, which serve as seed sources. Beech shows the best survival and growth on the northern site, where the greatest number of new seedlings also appear. In contrast, oaks demonstrate much higher mortality than beech overall, with the highest mortality observed on the northern site and the highest survival on the southern site, where most of the new seedlings also appeared. Interestingly, however, surviving oaks grew faster on the northern site. Across microtopography, seedlings of all three tree species were most frequent on the slopes of micro-undulations. Beech individuals were taller in depressions, whereas oaks did not consistently demonstrate a size advantage across microhabitats. Spruce colonised vigorously and was the most abundant of the three species across microhabitats. Age-frequency analyses suggest an annual mortality rate of 3%–9%. Browsing damage was observed on 19% of beech seedlings and 9% of oak seedlings. The study shows that pioneer tree stands are suitable nursing sites for studied climax tree species, which can colonise these sites several kilometres away from mature trees, and their establishment involves a complex interplay between distance to seed source and local microclimatic conditions. Our resurvey indicates that later successional stages may increasingly be shaped by shade-tolerant beech and spruce under the developing canopy. Full article

To address the serious ecological problems caused by long-term mining in the Muli Coalfield, a three-year ecological restoration project was initiated in 2020. The Jvhugeng mining area was the largest and most ecologically damaged area in the Muli Coalfield. Vegetation restoration is the core of mine ecological restoration. Scientific evaluation of the vegetation restoration status in the Jvhugeng mining area is significant for comprehensively revealing ecological restoration effectiveness in the Muli Coalfield. Based on Sentinel-2’s spectral and temporal advantages and GF-1/GF-6’s high spatial resolution in detailed portrayal, fractional vegetation cover (FVC) and landscape pattern index were determined separately. Thus, the vegetation restoration effectiveness and spatiotemporal dynamics of the Jvhugeng mining area from 2020 to 2023 were evaluated in terms of structural and functional dimensions. The results show that, from 2020 to 2023, vegetation cover extent (varying from 8.77 km² in 2020 to a peak of 17.93 km² in 2022 and then decreasing to 13.48 km² in 2023) and FVC (from 0.33 in 2020 to about 0.50 during 2021–2023) first increased sharply and then fluctuated. Vegetation regions with both high FVC and dominant landscape features also presented the characteristics of rapid expansion and then fluctuation. Vegetation restoration demonstrated significant effectiveness, with the natural ecological environment restored to some extent and remaining stable. Newly vegetated regions had high FVC and significant landscape pattern characteristics. However, vegetation cover expansion also led to further fragmentation and morphological complexity of vegetation landscape patterns in the study area. The results can provide a basis for quantitatively assessing ecological restoration effectiveness in the Jvhugeng mining area and even the Muli Coalfield. This can also provide a dual-source data synergy technical reference for dynamic monitoring and effective evaluation of vegetation restoration in other mining areas. Full article

To investigate the bending performance and damage characteristics of segmental joints with double sealing gaskets in large-diameter shield tunnels under high water pressure, this study established a three-dimensional high-fidelity numerical model of the segment-joint system based on the Pearl River Estuary Tunnel project. A comprehensive analysis was conducted on the mechanical and deformation behavior of large-diameter shield tunnel segmental joints under combined compressive/flexural loading. The research systematically examined the evolving relationships between bending moments, vertical displacements, and joint opening at the double-sealed gasketed joints under varying axial compression conditions, thereby elucidating the phased characteristics of joint deformation. The results indicate that the deformation patterns of double-sealed gasketed segmental joints under compressive/flexural loading exhibit pronounced nonlinearity and stage-dependent features. Both positive and negative bending moment scenarios demonstrate four distinct failure phases. Under high-water-pressure conditions, structural damage initiation consistently occurs at waterproof sealing grooves and bolt holes, regardless of bending moment direction. As loading intensifies, cracks propagate symmetrically at 45° angles from the joint interface, generating extended fracture networks, which creates additional water infiltration pathways, significantly compromising the joint’s waterproofing integrity. Full article

Background: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder with limited treatment options. Emerging evidence reveals bidirectional crosstalk between gut and brain through inflammatory signaling, leading us to hypothesize that anti-neuroinflammatory agents may concurrently ameliorate intestinal inflammation. The scorpion venom-derived heat-resistant synthetic peptide (SVHRSP), a bioactive peptide initially identified in scorpion venom and subsequently synthesized by our laboratory, possesses neuroprotective, anti-inflammatory, and antioxidative activities. Its properties make SVHRSP a promising candidate for investigating the therapeutic potential of anti-neuroinflammatory strategies in mitigating intestinal inflammation. Methods: Using a chronic dextran sodium sulfate (DSS)-induced colitis model in wild-type and α7 nicotinic acetylcholine receptor (α7nAChR) knockout mice, along with lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, we assessed SVHRSP’s effects on inflammation, histopathology, gut permeability, oxidative stress markers, and α7nAChR-Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling. Results: SVHRSP treatment significantly ameliorated colitis symptoms in wild-type mice by reducing inflammation, repairing histological damage, restoring gut barrier function, and attenuating oxidative stress, with these effects abolished in α7nAChR knockout mice. Mechanistically, SVHRSP activated JAK2/STAT3 signaling through α7nAChR engagement, suppressing proinflammatory cytokine production in macrophages. Conclusion: These results demonstrated that SVHRSP alleviated intestinal inflammation via α7nAChR-dependent JAK2/STAT3 activation. Combined with its known neuroprotective properties, our findings support the repurposing of this neuroactive peptide, SVHRSP, for treating intestinal inflammatory disorders. Full article

Composite engine fan blades are critical aircraft engine components, and their failure can compromise the safe and reliable operation of the entire aircraft. To enhance aircraft availability and safety within a condition-based maintenance framework, effective methods are needed to identify damage and monitor the blades’ condition throughout manufacturing and operation. This paper presents a unique experimental framework for real-time monitoring of composite engine blades utilizing state-of-the-art structural health monitoring (SHM) technologies, discussing the associated benefits and challenges. A case study is conducted on a representative Foreign Object Damage (FOD) panel, a substructure of a LEAP (Leading Edge Aviation Propulsion) engine fan blade, which is a curved, 3D-woven Carbon Fiber Reinforced Polymer (CFRP) panel with a secondary bonded steel leading edge. The loading scheme involves incrementally increasing, cyclic 4-point bending (loading–unloading) to induce controlled damage growth, simulating in-operation conditions and allowing evaluation of flexural properties before and after degradation. External damage, simulating foreign object impact common during flight, is introduced using a drop tower apparatus either before or during testing. The panel’s condition is monitored in-situ and in real time by two types of SHM sensors: screen-printed piezoelectric sensors for guided ultrasonic wave propagation studies and surface-bonded Fiber Bragg Grating (FBG) strain sensors. Experiments are conducted until panel collapse, and degradation is quantified by the reduction in initial stiffness, derived from the experimental load-displacement curves. This paper aims to demonstrate this unique experimental setup and the resulting SHM data, highlighting both the potential and challenges of this SHM framework for monitoring complex composite structures, while an attempt is made at correlating SHM data with structural degradation. Full article

Graphene, owing to its exceptional mechanical properties and interfacial modulation capability, is considered an ideal material for enhancing the interfacial strength and damage resistance during the fabrication of ultra-thin lithium foils. Although previous studies have demonstrated the reinforcing effects of graphene on lithium metal interfaces, most analyses have been restricted to single-temperature or idealized substrate conditions, lacking systematic investigations under practical, multi-temperature environments. Consequently, the influence of graphene coatings on lithium-ion conductivity and mechanical stability under real thermal conditions remains unclear. To address this gap, we employ LAMMPS-based molecular dynamics simulations to construct atomic-scale models of pristine lithium and graphene-coated lithium (C/Li) interfaces at three representative temperatures. Through comprehensive analyses of dislocation evolution, root-mean-square displacement, frictional response, and lithium-ion diffusion, we find that graphene coatings synergistically alleviate interfacial stress, suppress crack initiation, reduce friction, and enhance ionic conductivity, with these effects being particularly pronounced at elevated temperatures. These findings reveal the coupled mechanical and electrochemical regulation imparted by graphene, providing a theoretical basis for optimizing the structure of next-generation high-performance lithium metal anodes and laying the foundation for advanced interfacial engineering in battery technologies. Full article

Background: In addition to clinical examinations, confirmatory investigations are frequently performed to determine brain death (BD). Among other perfusion tests, brain perfusion scintigraphy (BPS) has been shown to be a reliable tool for the detection of brain circulatory arrest, particularly in cases with inconclusive clinical status or potential pharmacological interactions. Methods: Evaluation for brain death included standardized clinical examinations by two experienced neuro-intensive medicine specialists, followed by ancillary brain perfusion tests. BPS with the lipophilic tracer ^99mTc-hexamethylpropyleneamine oxime (HMPAO) was performed according to a standardized protocol. Imaging results, additional confirmatory test results, as well as clinical parameters were prospectively recorded. Results: BPS was performed in 30 patients (18 male, 12 female; median age 55.5 years, range 0.1–79.8 years). Eight patients underwent decompressive craniectomy (DC) prior to BD evaluation, three patients were supported by veno-arterial extracorporeal membrane oxygenation (vaECMO), and one patient by a left ventricular assist device (LVAD). The median interval between the initial brain-damaging event and BPS was 4.0 days (range 1–18 days). BPS demonstrated brain perfusion cessation in all patients. A concomitant single-photon emission computed tomography (SPECT) was required in one patient. There were no technical failures requiring a re-examination. Conclusions: BPS is a feasible, safe, and technically robust confirmatory test in BD diagnosis. BPS yielded unambiguous results, particularly in cases with inconclusive results of other ancillary tests, in neonates, young children and patients after DC. It is applicable to patients supported by LVAD and vaECMO. Full article

Background and Objectives: Doxorubicin (DOX) is a potential chemotherapeutic whose clinical application is limited by hepatotoxicity mediated through apoptosis, endoplasmic reticulum (ER) stress, and oxidative stress (OS). This study aimed to assess the hepatoprotective impact of methylene blue (MB) against DOX-induced liver injury. Methods: Forty rats were arbitrarily divided equally into four groups: control, DOX (15 mg/kg, i.p., single dose), MB (4 mg/kg, i.p., daily for 7 days), and DOX + MB (same regimen, MB initiated 1 h post DOX). Serum ALT, AST, and γ-GT were measured, along with hepatic TAC and HO-1. ELISA quantified PERK, GRP78, and CHOP. Immunohistochemistry assessed Caspase-3, p53, NF-κB, and Nrf2. Histopathological evaluation was performed using H&E staining. Results: DOX administration significantly elevated ALT, AST, γ-GT, HO-1, PERK, GRP78, and CHOP while reducing TAC and Nrf2 expression. Strong Caspase-3, p53, and NF-κB immunoreactivity and severe histopathological damage were observed. MB treatment markedly reversed these changes, restoring antioxidant status, downregulating ER stress markers, preserving Nrf2 expression, and improving hepatic architecture. Conclusions: MB exerts significant hepatoprotection against DOX-induced injury, likely via attenuation of OS, ER stress, apoptosis, and inflammation. Full article

Numerical simulations, unlike experimental studies, eliminate material and setup costs while significantly reducing testing time. In this study, a random distribution program for steel-recycled polyethylene terephthalate hybrid fiber recycled concrete (SRPRAC) was developed in Python (3.11), enabling direct generation in Abaqus. Mesoscopic simulation parameters were calibrated through debugging and sensitivity analysis. The simulations examined the compressive failure mode of SRPRAC and the influence of different factors. Results indicate that larger recycled coarse aggregate particle sizes intensify tensile and compressive damage in the interfacial transition zone between the coarse aggregate and mortar. Loading rate strongly affects outcomes, while smaller mesh sizes yield more stable results. Stronger boundary constraints at the top and bottom surfaces lead to higher peak stress, peak strain, and residual stress. Failure was mainly distributed within the specimen, forming a distinct X-shaped damage zone. Increasing fiber content reduced the equivalent plastic strain area above the compressive failure threshold, though the effect diminished beyond 1% total fiber volume. During initial loading, steel fibers carried higher tensile stresses, whereas recycled polyethylene terephthalate fibers (rPETF) contributed less. After peak load, tensile stress in rPETF increased significantly, complementing the gradual stress increase in steel fibers. The mesoscopic model effectively captured the stress–strain damage behavior of SRPRAC under compression. Full article

Growth kinetics and the irreversible deformation of thermally growth oxide (TGO) critically affect the delamination and cracking at the interface of thermal barrier coatings (TBCs). In this study, TGO dynamic growth during furnace cycles is simulated using three different approaches. The stress evolution and damage characteristics near the interface are compared in various TGO growth modes. Furthermore, the influences of TGO creep at high temperatures on the interface delamination and coating failure are also investigated. The results reveal that TGO growth achieved through material transformation (growth mode III) leads to earlier interface delamination compared to element swelling methods (growth mode I and II). Although the stress value in growth mode II is higher than that in growth mode I after all cycles, earlier delamination and spallation occur in mode I due to faster stress accumulation in the initial stage of thermal cycle. Moreover, rapid TGO creep is found to reduce the accumulated stress within the ceramic layer and delay the onset of interface delamination. These findings provide important theoretical insights for the development and life assessment of advanced TBCs. Full article

Accurate and comprehensive characterization of high-steep slopes is crucial for real-time risk prediction, disaster assessment, and damage evolution monitoring. The study focused on a high-steep rocky slope along the Yanjiang Expressway in Sichuan Province, China. A novel digital reconstruction method was introduced, which integrates terrestrial laser scanning (TLS) and unmanned aerial vehicle (UAV) photogrammetry through a Transformer-based method combining GeoTransformer with the Maximal Cliques (MAC) algorithm. The results indicated that TLS excels in capturing fine-scale features, whereas UAV demonstrates superior performance in large-scale terrain reconstruction. However, multi-sensor data exhibit heterogeneity in terms of partial overlap, large outliers, and density differences. To address these challenges, the GeoTransformer-MAC framework extracts geometrically invariant features from cross-source point cloud (CSPC) to establish initial correspondences, followed by rigorous screening of high-quality locally consistent correspondences to optimize transformation parameters. This method achieves accurate digital reconstruction of the high-steep rock slope. Global and local error analyses verify the model’s superiority in both overall slope characterization and fine-scale feature representation. Compared with the TLS-only model and the conventional method, the Transformer-based method improves the slope model integrity by 85.58%, increases the data density by 9.71%, and improves the accuracy by nearly threefold. This study provides a novel approach for the digital modeling of complex terrains, which serves the refined identification and modeling of geohazards for high-steep slopes in complex mountainous regions. Full article