ijms-logo

Journal Browser

Journal Browser

Cellular and Molecular Progression of Cardiovascular Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 2663

Special Issue Editors


E-Mail
Guest Editor
CNR Institute of Clinical Physiology, 56124 Pisa, Italy
Interests: cardiovascular disease; genetics; miRNA; telomeres; mitochondria; molecular epidemiology; ionizing radiation; radiobiology

E-Mail Website
Guest Editor
Cardiology Unit, Fondazione Toscana Gabriele Monasterio, 54100 Massa, Italy
Interests: coronary artery disease; cardiology; abdominal aortic aneurysm; thoracic aortic aneurysm; carotid disease; aortic disease
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Insititute of Clinical Physiology, National Research Council of Italy, 56124 Pisa, Italy
Interests: sensors; biosensors; artificial Intelligence; wearable sensors; biomedical signal processing; machine learning; chemosensory analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) are the leading cause of death globally, claiming an estimated 18 million lives annually. Despite extensive research, gaining novel insights into the pathophysiology and molecular mechanisms of CVDs through both basic and clinical research is crucial. This effort is essential for identifying new diagnostic/prognostic tools and developing therapeutic strategies that can enhance patient management and outcomes.

The integration of multi-omics data (including genomics, epigenomics, transcriptomics, proteomics, and metabolomics) offers a holistic perspective on the patient, providing insights into regulatory mechanisms, pathways, and networks involved in the development and progression of CVDs. Furthermore, artificial intelligence (AI) stands out as a powerful framework capable of recognizing complex patterns within large-scale clinical and molecular data. Its potential to improve risk prediction is substantial, allowing for the identification of biomarkers for more accurate diagnoses, the prediction of treatment outcomes, and the development of novel therapies for personalized approaches.

For this Special Issue, we invite investigators to contribute original research and review papers. The aim is to cover the most recent advances in the molecular and cellular mechanisms underlying CVDs. Manuscripts that also discuss the value of AI-related strategies in Molecular Level.

Dr. Andrea Borghini
Dr. Antonio Rizza
Dr. Alessandro Tonacci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular diseases
  • multi-omics data
  • biomarkers
  • molecular level
  • pathophysiology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 6121 KiB  
Article
Novel Identification of Ankyrin-R in Cardiac Fibroblasts and a Potential Role in Heart Failure
by Aaron D. Argall, Holly C. Sucharski-Argall, Luke G. Comisford, Sallie J. Jurs, Jack T. Seminetta, Michael J. Wallace, Casey A. Crawford, Sarah S. Takenaka, Mei Han, Mona El Refaey, Thomas J. Hund, Peter J. Mohler and Sara N. Koenig
Int. J. Mol. Sci. 2024, 25(15), 8403; https://doi.org/10.3390/ijms25158403 - 1 Aug 2024
Viewed by 648
Abstract
Altered ankyrin-R (AnkR; encoded by ANK1) expression is associated with diastolic function, left ventricular remodeling, and heart failure with preserved ejection fraction (HFpEF). First identified in erythrocytes, the role of AnkR in other tissues, particularly the heart, is less studied. Here, we [...] Read more.
Altered ankyrin-R (AnkR; encoded by ANK1) expression is associated with diastolic function, left ventricular remodeling, and heart failure with preserved ejection fraction (HFpEF). First identified in erythrocytes, the role of AnkR in other tissues, particularly the heart, is less studied. Here, we identified the expression of both canonical and small isoforms of AnkR in the mouse myocardium. We demonstrate that cardiac myocytes primarily express small AnkR (sAnkR), whereas cardiac fibroblasts predominantly express canonical AnkR. As canonical AnkR expression in cardiac fibroblasts is unstudied, we focused on expression and localization in these cells. AnkR is expressed in both the perinuclear and cytoplasmic regions of fibroblasts with considerable overlap with the trans-Golgi network protein 38, TGN38, suggesting a potential role in trafficking. To study the role of AnkR in fibroblasts, we generated mice lacking AnkR in activated fibroblasts (Ank1-ifKO mice). Notably, Ank1-ifKO mice fibroblasts displayed reduced collagen compaction, supportive of a novel role of AnkR in normal fibroblast function. At the whole animal level, in response to a heart failure model, Ank1-ifKO mice displayed an increase in fibrosis and T-wave inversion compared with littermate controls, while preserving cardiac ejection fraction. Collagen type I fibers were decreased in the Ank1-ifKO mice, suggesting a novel function of AnkR in the maturation of collagen fibers. In summary, our findings illustrate the novel expression of AnkR in cardiac fibroblasts and a potential role in cardiac function in response to stress. Full article
(This article belongs to the Special Issue Cellular and Molecular Progression of Cardiovascular Diseases)
Show Figures

Graphical abstract

Review

Jump to: Research

26 pages, 2099 KiB  
Review
Cardiovascular Effects of Herbal Products and Their Interaction with Antihypertensive Drugs—Comprehensive Review
by Kinga-Ilona Nyulas, Zsuzsánna Simon-Szabó, Sándor Pál, Márta-Andrea Fodor, Lóránd Dénes, Margit Judit Cseh, Enikő Barabás-Hajdu, Bernadett Csipor, Juliánna Szakács, Zoltán Preg, Márta Germán-Salló and Enikő Nemes-Nagy
Int. J. Mol. Sci. 2024, 25(12), 6388; https://doi.org/10.3390/ijms25126388 - 9 Jun 2024
Cited by 1 | Viewed by 1313
Abstract
Hypertension is a highly prevalent population-level disease that represents an important risk factor for several cardiovascular complications and occupies a leading position in mortality statistics. Antihypertensive therapy includes a wide variety of drugs. Additionally, the potential antihypertensive and cardioprotective effects of several phytotherapy [...] Read more.
Hypertension is a highly prevalent population-level disease that represents an important risk factor for several cardiovascular complications and occupies a leading position in mortality statistics. Antihypertensive therapy includes a wide variety of drugs. Additionally, the potential antihypertensive and cardioprotective effects of several phytotherapy products have been evaluated, as these could also be a valuable therapeutic option for the prevention, improvement or treatment of hypertension and its complications. The present review includes an evaluation of the cardioprotective and antihypertensive effects of garlic, Aloe vera, green tea, Ginkgo biloba, berberine, ginseng, Nigella sativa, Apium graveolens, thyme, cinnamon and ginger, and their possible interactions with antihypertensive drugs. A literature search was undertaken via the PubMed, Google Scholar, Embase and Cochrane databases. Research articles, systematic reviews and meta-analyses published between 2010 and 2023, in the English, Hungarian, and Romanian languages were selected. Full article
(This article belongs to the Special Issue Cellular and Molecular Progression of Cardiovascular Diseases)
Show Figures

Figure 1

Back to TopTop