Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (173,221)

Search Parameters:
Keywords = integrativeness

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
20 pages, 1681 KB  
Article
Reading Between the Lines: Digital Annotation Insights from Heritage and L2 Learners
by Edna Velásquez
Languages 2025, 10(9), 207; https://doi.org/10.3390/languages10090207 (registering DOI) - 26 Aug 2025
Abstract
This study investigates how Spanish heritage language (SHL) learners, and second language (L2) learners cognitively and socially engage with texts through collaborative digital annotations. Conducted in two advanced online writing courses with forty students, the study employed Perusall, a social annotation platform, to [...] Read more.
This study investigates how Spanish heritage language (SHL) learners, and second language (L2) learners cognitively and socially engage with texts through collaborative digital annotations. Conducted in two advanced online writing courses with forty students, the study employed Perusall, a social annotation platform, to examine reading behaviors and peer interactions. Quantitative analysis revealed both similarities and differences in strategy use: while both groups demonstrated equal levels of interaction, SHL learners favored Evaluating and Connecting strategies, suggesting reflective, experience-based engagement, whereas L2 learners more frequently used Questioning and Translating strategies, indicating a more analytical approach. Survey responses further highlighted perceived gains in vocabulary, motivation, grammar, and academic language awareness. These findings challenge deficit-based assumptions about SHL literacy and underscore the value of integrating culturally relevant, digitally mediated tasks in language instruction. The study affirms that collaborative annotation not only fosters cognitive engagement but also promotes social presence and academic identity development. It offers practical recommendations for grouping, scaffolding, and platform use, and contributes to a broader understanding of how digital tools can support inclusive, meaningful reading experiences for diverse learners in the twenty-first-century classroom. Full article
(This article belongs to the Special Issue Language Processing in Spanish Heritage Speakers)
Show Figures

Figure 1

17 pages, 4900 KB  
Article
An Ease-Off Based Tooth Contact Analysis Method for Measured Face Gear Flanks
by Zhongwei Tang, Yuansheng Zhou and Jinyuan Tang
Appl. Sci. 2025, 15(17), 9336; https://doi.org/10.3390/app15179336 (registering DOI) - 26 Aug 2025
Abstract
To rapidly evaluate the meshing performance of manufactured face-gear drives, this study proposes an efficiency-optimized tooth contact analysis (TCA) method for measured gear flanks based on Ease-off surface. Initially, mathematical models of the pinion and face-gear tooth flanks are established. A TCA framework [...] Read more.
To rapidly evaluate the meshing performance of manufactured face-gear drives, this study proposes an efficiency-optimized tooth contact analysis (TCA) method for measured gear flanks based on Ease-off surface. Initially, mathematical models of the pinion and face-gear tooth flanks are established. A TCA framework leveraging conjugate relationships and Ease-off surfaces is then developed. Subsequently, measured flank data are fitted into continuous error surfaces through Bicubic spline fitting, enabling full-tooth flank error mapping. These error distributions are integrated into the Ease-off surface model to simulate realistic meshing behavior, extracting critical performance metrics including contact paths and transmission errors. Validation through computational TCA, finite element analysis (FEA), and rolling tests confirm the method’s accuracy and computational efficiency. Full article
(This article belongs to the Section Applied Industrial Technologies)
Show Figures

Figure 1

29 pages, 15237 KB  
Article
Integrating BIM, Machine Learning, and PMBOK for Green Project Management in Saudi Arabia: A Framework for Energy Efficiency and Environmental Impact Reduction
by Maher Abuhussain, Ali Hussain Alhamami, Khaled Almazam, Omar Humaidan, Faizah Mohammed Bashir and Yakubu Aminu Dodo
Buildings 2025, 15(17), 3031; https://doi.org/10.3390/buildings15173031 (registering DOI) - 25 Aug 2025
Abstract
This study introduces a comprehensive framework combining building information modeling (BIM), project management body of knowledge (PMBOK), and machine learning (ML) to optimize energy efficiency and reduce environmental impacts in Riyadh’s construction sector. The suggested methodology utilizes BIM for dynamic energy simulations and [...] Read more.
This study introduces a comprehensive framework combining building information modeling (BIM), project management body of knowledge (PMBOK), and machine learning (ML) to optimize energy efficiency and reduce environmental impacts in Riyadh’s construction sector. The suggested methodology utilizes BIM for dynamic energy simulations and design visualization, PMBOK for integrating sustainability into project-management processes, and ML for predictive modeling and real-time energy optimization. Implementing an integrated model that incorporates building-management strategies and machine learning for both commercial and residential structures can offer stakeholders a thorough solution for forecasting energy performance and environmental impact. This is particularly essential in arid climates owing to specific conditions and environmental limitations. Using a simulation-based methodology, the framework was evaluated based on two representative case studies: (i) a commercial complex and (ii) a residential building. The neural network (NN), reinforcement learning (RL), and decision tree (DT) were implemented to assess performance in energy prediction and optimization. Results demonstrated notable seasonal energy savings, particularly in spring (15% reduction for commercial buildings) and fall (13% reduction for residential buildings), driven by optimized heating, ventilation, and air conditioning (HVAC) systems, insulation strategies, and window configurations. ML models successfully predicted energy consumption and greenhouse gas (GHG) emissions, enabling targeted mitigation strategies. GHG emissions were reduced by up to 25% in commercial and 20% in residential settings. Among the models, NN achieved the highest predictive accuracy (R2 = 0.95), while RL proved effective in adaptive operational control. This study highlights the synergistic potential of BIM, PMBOK, and ML in advancing green project management and sustainable construction. Full article
Show Figures

Figure 1

23 pages, 593 KB  
Review
Pediatric Spigelian Hernia and Spigelian–Cryptorchidism Syndrome: An Integrative Review
by Javier Arredondo Montero and María Rico-Jiménez
Children 2025, 12(9), 1120; https://doi.org/10.3390/children12091120 (registering DOI) - 25 Aug 2025
Abstract
Spigelian hernia (SH) is an infrequent aponeurotic defect in Spiegel’s semilunar line. The literature on pediatric SH is scarce. A comprehensive review of the previous literature was conducted. Eligible studies were identified by searching primary medical bibliography databases, and a pooled analysis of [...] Read more.
Spigelian hernia (SH) is an infrequent aponeurotic defect in Spiegel’s semilunar line. The literature on pediatric SH is scarce. A comprehensive review of the previous literature was conducted. Eligible studies were identified by searching primary medical bibliography databases, and a pooled analysis of published case-level data was performed. Medians and interquartile ranges were used to describe the quantitative variables and proportions for categorical variables. The Kruskal–Wallis, Mann–Whitney U, and Fisher’s exact tests were used to compare group variables. Spearman’s and Pearson’s correlation analyses were used to assess the degree of correlation between variables, while Cramér’s V was applied to evaluate the degree of association among the variables. A p-value < 0.05 (two-tailed) was considered statistically significant. Our search identified 82 publications reporting on 123 patients (106 male, 86.2%), with an age range of 0–21 years. Forty-seven patients (38.2%) had a left-sided SH, fifty-six (45.5%) had a right-sided SH, and thirteen (10.6%) had a bilateral SH. Traumatic SH, mostly from bicycle injuries, accounted for 45 cases (36.6%), while 41 (33.3%) were associated with undescended testis (UDT). In this series of published cases, hernia incarceration/strangulation (I/S) was reported in 15 patients (12.2%), who were significantly younger (p = 0.02). Surgical correction was performed in 95 cases (77.2%), 14 of them laparoscopically, with a 35.7% conversion rate. Eight cases (6.5%) were managed conservatively. Overall, outcomes were favorable. SH is an infrequent pediatric condition that, based on the synthesized literature, predominantly affects males. The published cases suggest two main clinical phenotypes: a congenital form, often linked to ipsilateral UDT, and an acquired form, typically resulting from trauma. Analysis of the reported data indicates a higher risk of incarceration in early childhood. Surgical treatment is the most frequently reported approach with generally favorable outcomes, whereas the evidence for conservative management remains limited. This comprehensive review highlights the dual nature of pediatric SH and underscores the need for a high index of suspicion in relevant clinical scenarios. Full article
(This article belongs to the Section Pediatric Surgery)
Show Figures

Figure 1

22 pages, 4341 KB  
Article
Radio Frequency Passive Tagging System Enabling Object Recognition and Alignment by Robotic Hands
by Armin Gharibi, Mahmoud Tavakoli, André F. Silva, Filippo Costa and Simone Genovesi
Electronics 2025, 14(17), 3381; https://doi.org/10.3390/electronics14173381 (registering DOI) - 25 Aug 2025
Abstract
Robotic hands require reliable and precise sensing systems to achieve accurate object recognition and manipulation, particularly in environments where vision- or capacitive-based approaches face limitations such as poor lighting, dust, reflective surfaces, or non-metallic materials. This paper presents a novel radiofrequency (RF) pre-touch [...] Read more.
Robotic hands require reliable and precise sensing systems to achieve accurate object recognition and manipulation, particularly in environments where vision- or capacitive-based approaches face limitations such as poor lighting, dust, reflective surfaces, or non-metallic materials. This paper presents a novel radiofrequency (RF) pre-touch sensing system that enables robust localization and orientation estimation of objects prior to grasping. The system integrates a compact coplanar waveguide (CPW) probe with fully passive chipless RF resonator tags fabricated using a patented flexible and stretchable conductive ink through additive manufacturing. This approach provides a low-cost, durable, and highly adaptable solution that operates effectively across diverse object geometries and environmental conditions. The experimental results demonstrate that the proposed RF sensor maintains stable performance under varying distances, orientations, and inter-tag spacings, showing robustness where traditional methods may fail. By combining compact design, cost-effectiveness, and reliable near-field sensing independent of an object or lighting, this work establishes RF sensing as a practical and scalable alternative to optical and capacitive systems. The proposed method advances robotic perception by offering enhanced precision, resilience, and integration potential for industrial automation, warehouse handling, and collaborative robotics. Full article
23 pages, 689 KB  
Article
Teacher Perceptions of Physical Activity in Special Education: Beliefs, Barriers, and Implementation Practices
by Carmit Gal, Chen Hanna Ryder, Oshrat On and Shani Raveh Amsalem
Educ. Sci. 2025, 15(9), 1100; https://doi.org/10.3390/educsci15091100 (registering DOI) - 25 Aug 2025
Abstract
Physical activity (PA) integration in special education has gained recognition as a neuroeducational intervention supporting emotional and social development in students with special educational needs and disabilities (SEND), yet teacher perceptions remain underexplored. This cross-sectional study examined how Israeli special education teachers perceive [...] Read more.
Physical activity (PA) integration in special education has gained recognition as a neuroeducational intervention supporting emotional and social development in students with special educational needs and disabilities (SEND), yet teacher perceptions remain underexplored. This cross-sectional study examined how Israeli special education teachers perceive physical activity’s benefits and how teaching experience and educational setting influence these perceptions. A structured questionnaire was administered to 45 female special education teachers from northern Israel. The instrument assessed perceptions of physical activity’s emotional benefits, social outcomes, and implementation practices using Likert-type scales. Teachers strongly endorsed PA as a means to foster emotional resilience and coping, with most preferring group-based activities. Mixed activities were the most preferred approach, followed by movement games. Experienced teachers reported significantly stronger perceptions of emotional benefits compared to less experienced colleagues. Secondary teachers demonstrated higher extracurricular promotion and perceived greater social benefits than elementary teachers. Despite positive attitudes, implementation barriers, including infrastructure limitations and training gaps, were evident. These findings highlight physical activity’s potential as a neuroeducational tool for fostering regulation and inclusion while revealing the need for differentiated professional development, infrastructure investment, and policy integration. Full article
(This article belongs to the Section Special and Inclusive Education)
31 pages, 693 KB  
Article
How Does Digital Financial Inclusion Affect Rural Land Transfer? Evidence from China
by Chunyan He, Lu Zhou, Fang Qu and Peng Xue
Land 2025, 14(9), 1723; https://doi.org/10.3390/land14091723 (registering DOI) - 25 Aug 2025
Abstract
Farmers’ land transfer practices optimize the allocation of agricultural resources by transferring them to more efficient operators. This enhances agricultural productivity and advances rural revitalization. However, due to the lack of financial institution outlets in rural areas, the availability of financial services in [...] Read more.
Farmers’ land transfer practices optimize the allocation of agricultural resources by transferring them to more efficient operators. This enhances agricultural productivity and advances rural revitalization. However, due to the lack of financial institution outlets in rural areas, the availability of financial services in rural areas is limited, which in turn hinders the transfer of rural land. This study examines the impact of digital financial inclusion, characterized by the deep integration of internet technology and financial services, on farmers’ land transfer behavior in China. The study uses data from the China Family Panel Studies (2012–2022) and provincial digital financial inclusion data. The results show that digital financial inclusion significantly promotes rural land transfer-out. The mechanisms reveal two pathways: (1) digital financial inclusion expands non-agricultural entrepreneurship by easing credit constraints and reducing reliance on land livelihoods; (2) it increases participation in commercial insurance, mitigating risks of land abandonment. Heterogeneity analysis reveals stronger effects in eastern China and among educated households. Theoretically, the study identifies the dual role of financial technology in reshaping rural land markets through credit access and risk management. Practically, it reveals how DFI influences land transfer behavior, providing a basis for the government to formulate policies that combine the two, ultimately enhancing the production capacity, operational efficiency, and market competitiveness of smallholder farmers. The findings offer global insights for developing countries that are leveraging digital finance to activate rural land markets and achieve digital financial inclusion. Full article
(This article belongs to the Special Issue Land Use Policy and Food Security: 2nd Edition)
35 pages, 2019 KB  
Review
Non-Electrophilic Activation of NRF2 in Neurological Disorders: Therapeutic Promise of Non-Pharmacological Strategies
by Chunyan Li, Keren Powell, Luca Giliberto, Christopher LeDoux, Cristina d’Abramo, Daniel Sciubba and Yousef Al Abed
Antioxidants 2025, 14(9), 1047; https://doi.org/10.3390/antiox14091047 (registering DOI) - 25 Aug 2025
Abstract
Nuclear factor erythroid 2-related factor 2 (NRF2) serves as a master transcriptional regulator of cellular antioxidant responses through orchestration of cytoprotective gene expression, establishing its significance as a therapeutic target in cerebral pathophysiology. Classical electrophilic NRF2 activators, despite potent activation potential, exhibit paradoxically [...] Read more.
Nuclear factor erythroid 2-related factor 2 (NRF2) serves as a master transcriptional regulator of cellular antioxidant responses through orchestration of cytoprotective gene expression, establishing its significance as a therapeutic target in cerebral pathophysiology. Classical electrophilic NRF2 activators, despite potent activation potential, exhibit paradoxically reduced therapeutic efficacy relative to single antioxidants, attributable to concurrent oxidative stress generation, glutathione depletion, mitochondrial impairment, and systemic toxicity. Although emerging non-electrophilic pharmacological activators offer therapeutic potential, their utility remains limited by bioavailability and suboptimal potency, underscoring the imperative for innovative therapeutic strategies to harness this cytoprotective pathway. Non-pharmacological interventions, including neuromodulation, physical exercise, and lifestyle modifications, activate NRF2 through non-canonical, non-electrophilic pathways involving protein–protein interaction inhibition, KEAP1 degradation, post-translational and transcriptional modulation, and protein stabilization, though mechanistic characterization remains incomplete. Such interventions utilize multi-mechanistic approaches that synergistically integrate multiple non-electrophilic NRF2 pathways or judiciously combine electrophilic and non-electrophilic mechanisms while mitigating electrophile-induced toxicity. This strategy confers neuroprotective effects without the contraindications characteristic of classical electrophilic activators. This review comprehensively examines the mechanistic underpinnings of non-pharmacological NRF2 modulation, highlighting non-electrophilic activation pathways that bypass the limitations inherent to electrophilic activators. The evidence presented herein positions non-pharmacological interventions as viable therapeutic approaches for achieving non-electrophilic NRF2 activation in the treatment of cerebrovascular and neurodegenerative pathologies. Full article
(This article belongs to the Special Issue Oxidative Stress and NRF2 in Health and Disease—2nd Edition)
Show Figures

Figure 1

32 pages, 5540 KB  
Article
High-Accuracy Cotton Field Mapping and Spatiotemporal Evolution Analysis of Continuous Cropping Using Multi-Source Remote Sensing Feature Fusion and Advanced Deep Learning
by Xiao Zhang, Zenglu Liu, Xuan Li, Hao Bao, Nannan Zhang and Tiecheng Bai
Agriculture 2025, 15(17), 1814; https://doi.org/10.3390/agriculture15171814 (registering DOI) - 25 Aug 2025
Abstract
Cotton is a globally strategic crop that plays a crucial role in sustaining national economies and livelihoods. To address the challenges of accurate cotton field extraction in the complex planting environments of Xinjiang’s Alaer reclamation area, a cotton field identification model was developed [...] Read more.
Cotton is a globally strategic crop that plays a crucial role in sustaining national economies and livelihoods. To address the challenges of accurate cotton field extraction in the complex planting environments of Xinjiang’s Alaer reclamation area, a cotton field identification model was developed that integrates multi-source satellite remote sensing data with machine learning methods. Using imagery from Sentinel-2, GF-1, and Landsat 8, we performed feature fusion using principal component, Gram–Schmidt (GS), and neural network techniques. Analyses of spectral, vegetation, and texture features revealed that the GS-fused blue bands of Sentinel-2 and Landsat 8 exhibited optimal performance, with a mean value of 16,725, a standard deviation of 2290, and an information entropy of 8.55. These metrics improved by 10,529, 168, and 0.28, respectively, compared with the original Landsat 8 data. In comparative classification experiments, the endmember-based random forest classifier (RFC) achieved the best traditional classification performance, with a kappa value of 0.963 and an overall accuracy (OA) of 97.22% based on 250 samples, resulting in a cotton-field extraction error of 38.58 km2. By enhancing the deep learning model, we proposed a U-Net architecture that incorporated a Convolutional Block Attention Module and Atrous Spatial Pyramid Pooling. Using the GS-fused blue band data, the model achieved significantly improved accuracy, with a kappa coefficient of 0.988 and an OA of 98.56%. This advancement reduced the area estimation error to 25.42 km2, representing a 34.1% decrease compared with that of the RFC. Based on the optimal model, we constructed a digital map of continuous cotton cropping from 2021 to 2023, which revealed a consistent decline in cotton acreage within the reclaimed areas. This finding underscores the effectiveness of crop rotation policies in mitigating the adverse effects of large-scale monoculture practices. This study confirms that the synergistic integration of multi-source satellite feature fusion and deep learning significantly improves crop identification accuracy, providing reliable technical support for agricultural policy formulation and sustainable farmland management. Full article
(This article belongs to the Special Issue Computers and IT Solutions for Agriculture and Their Application)
38 pages, 3747 KB  
Article
Parametric Optimization of Artificial Neural Networks and Machine Learning Techniques Applied to Small Welding Datasets
by Vinícius Resende Rocha, Fran Sérgio Lobato, Pedro Augusto Queiroz de Assis, Carlos Roberto Ribeiro, Sebastião Simões da Cunha, Louriel Oliveira Vilarinho, João Rodrigo Andrade, Leonardo Rosa Ribeiro da Silva and Luiz Eduardo dos Santos Paes
Processes 2025, 13(9), 2711; https://doi.org/10.3390/pr13092711 (registering DOI) - 25 Aug 2025
Abstract
Establishing precise welding parameters is essential to achieving the desired bead geometry and ensuring consistent quality in manufacturing processes. However, determining the optimal configuration of parameters remains a challenge, particularly when relying on limited experimental data. This study proposes the use of artificial [...] Read more.
Establishing precise welding parameters is essential to achieving the desired bead geometry and ensuring consistent quality in manufacturing processes. However, determining the optimal configuration of parameters remains a challenge, particularly when relying on limited experimental data. This study proposes the use of artificial neural networks (ANNs), with their architecture optimized via differential evolution (DE), to predict key MAG welding parameters based on target bead geometry. To address data limitations, cross-validation and data augmentation techniques were employed to enhance model generalization. In addition to the ANN model, machine learning algorithms commonly recommended for small datasets, such as K-nearest neighbors (KNNs) and support vector machines (SVMs), were implemented for comparative evaluation. The results demonstrate that all models achieved good predictive performance, with SVM showing the highest accuracy among the techniques tested, reinforcing the value of integrating traditional ML models for benchmarking purposes in low-data scenarios. Full article
(This article belongs to the Special Issue Artificial Intelligence in Process Innovation and Optimization)
18 pages, 6433 KB  
Article
Study on Nano-Grinding Characteristics and Formation Mechanism of Subsurface Damage in Monocrystalline Silicon
by Haipeng Yan, Haining Zhang, Siyuan Cao and Chao Wang
Micromachines 2025, 16(9), 976; https://doi.org/10.3390/mi16090976 (registering DOI) - 25 Aug 2025
Abstract
Monocrystalline silicon is an excellent semiconductor material for integrated circuits. Its surface quality has an enormous effect on its service life. The surfaces are formed by ultra-precision machining using nano-grinding, one of the technologies that can achieve surface roughness at the nano- or [...] Read more.
Monocrystalline silicon is an excellent semiconductor material for integrated circuits. Its surface quality has an enormous effect on its service life. The surfaces are formed by ultra-precision machining using nano-grinding, one of the technologies that can achieve surface roughness at the nano- or sub-nano-scale. Therefore, subsurface damage of monocrystalline silicon in nano-grinding was studied by establishing a molecular dynamics simulation model, and the impact of machining parameters on the force–thermal behavior was analyzed. The results reveal that the mechanism of subsurface damage is mainly structural phase transformation and amorphization. In nano-grinding of monocrystalline silicon, the tangential grinding force has a relatively major role in material removal. With increasing grinding depth and grinding speed, the grinding heat rises, and a certain degree of high temperature strengthens the toughness of the material, improving the subsurface quality of monocrystalline silicon. Therefore, subsurface damage in monocrystalline silicon can be controlled by reducing the grinding depth and increasing the grinding speed. Full article
(This article belongs to the Special Issue Functional Materials and Microdevices, 2nd Edition)
Show Figures

Figure 1

16 pages, 1018 KB  
Article
Honey Bee Foraging Decisions Are Shaped by Floral Trait Distinctiveness and Perception of Gains or Losses
by Juan C. Hernández, Jair E. García, Harrington Wells and Marisol Amaya-Márquez
Insects 2025, 16(9), 884; https://doi.org/10.3390/insects16090884 (registering DOI) - 25 Aug 2025
Abstract
The floral choices of honey bees (Apis mellifera) were studied using artificial flower patches to understand how foragers manage changing floral landscapes. Bees were observed under conditions where reward quality changed over time in blue and white flowers. We evaluated initial [...] Read more.
The floral choices of honey bees (Apis mellifera) were studied using artificial flower patches to understand how foragers manage changing floral landscapes. Bees were observed under conditions where reward quality changed over time in blue and white flowers. We evaluated initial learning and reversal learning, varying the magnitude of reward quality-difference and color distinctness in the honey bee’s color vision space (being either similar or more distinct). Flower color fidelity was higher when flower colors were more distinct, but it also made it more difficult for bees to abandon the flower color in the reversal learning phase. Smaller differences in reward quality reduced flower color fidelity and promoted reversal learning. When reward difference between flower colors was created (initial learning), a decrease in one of the flower color rewards elicited a stronger behavioral response from foragers than an increase in reward. Our work highlights that bees used and integrated information from different axes of information: distinctiveness of color cues, magnitude of reward difference, and directionality (being stronger for losses than gains). Thus, flower distinctiveness, opportunity cost, and loss aversion drive honey bee foraging decisions. Higher accuracy at initial learning has stronger costs in behavioral adaptations at changing floral landscapes. Full article
(This article belongs to the Special Issue Bee Conservation: Behavior, Health and Pollination Ecology)
Show Figures

Figure 1

10 pages, 1319 KB  
Article
Translocation of Insecticidal Bt Protein in Transgrafted Plants
by Arisa Ando, Hitomi Ohkubo, Hisae Maki, Takumi Nishiuchi, Takumi Ogawa, Tomofumi Mochizuki, Daisaku Ohta, Hiroaki Kodama and Taira Miyahara
BioTech 2025, 14(3), 64; https://doi.org/10.3390/biotech14030064 (registering DOI) - 25 Aug 2025
Abstract
Transgrafting constitutes a technique involving the integration of genetically modified (GM) and non-GM plant organisms. Typically, edible components derived from non-GM scions are categorized as non-GM food products, attributed to the absence of exogenous genetic material within their respective genomes. Non-GM food status [...] Read more.
Transgrafting constitutes a technique involving the integration of genetically modified (GM) and non-GM plant organisms. Typically, edible components derived from non-GM scions are categorized as non-GM food products, attributed to the absence of exogenous genetic material within their respective genomes. Non-GM food status could be compromised if proteins translocated across the graft interface. We investigated the movement of insecticidal Bacillus thuringiensis (Bt) crystal proteins, widely utilized in GM crop species. Tobacco plants engineered to express the Cry1Ab gene exhibited trace levels of Cry1Ab protein accumulation. In transgrafted plants, translocated Cry1Ab protein originating from GM rootstocks was detectable within scion foliar tissues but not within the seeds obtained from the non-GM scion. This result unequivocally demonstrates the capacity for Bt protein translocation from rootstocks to scions yet indicates a constrained distribution confined to scion tissues relatively close to the graft junction. While regulatory considerations necessitate a thorough appraisal of potential risks associated with Bt proteins, the results shown here facilitate the commercialization of the edible components as non-GM food products. Full article
(This article belongs to the Section Biotechnology Regulation)
Show Figures

Figure 1

41 pages, 9064 KB  
Article
PLSCO: An Optimization-Driven Approach for Enhancing Predictive Maintenance Accuracy in Intelligent Manufacturing
by Aymen Ramadan Mohamed Alahwel Besha, Opeoluwa Seun Ojekemi, Tolga Oz and Oluwatayomi Adegboye
Processes 2025, 13(9), 2707; https://doi.org/10.3390/pr13092707 (registering DOI) - 25 Aug 2025
Abstract
Predictive maintenance (PdM) is a cornerstone of smart manufacturing, enabling the early detection of equipment degradation and reducing unplanned downtimes. This study proposes an advanced machine learning framework that integrates the Extreme Learning Machine (ELM) with a novel hybrid metaheuristic optimization algorithm, the [...] Read more.
Predictive maintenance (PdM) is a cornerstone of smart manufacturing, enabling the early detection of equipment degradation and reducing unplanned downtimes. This study proposes an advanced machine learning framework that integrates the Extreme Learning Machine (ELM) with a novel hybrid metaheuristic optimization algorithm, the Polar Lights Salp Cooperative Optimizer (PLSCO), to enhance predictive modeling in manufacturing processes. PLSCO combines the strengths of the Polar Light Optimizer (PLO), Competitive Swarm Optimization (CSO), and Salp Swarm Algorithm (SSA), utilizing a cooperative strategy that adaptively balances exploration and exploitation. In this mechanism, particles engage in a competitive division process, where winners intensify search via PLO and losers diversify using SSA, effectively avoiding local optima and premature convergence. The performance of PLSCO was validated on CEC2015 and CEC2020 benchmark functions, demonstrating superior convergence behavior and global search capabilities. When applied to a real-world predictive maintenance dataset, the ELM-PLSCO model achieved a high prediction accuracy of 95.4%, outperforming baseline and other optimization-assisted models. Feature importance analysis revealed that torque and tool wear are dominant indicators of machine failure, offering interpretable insights for condition monitoring. The proposed approach presents a robust, interpretable, and computationally efficient solution for predictive maintenance in intelligent manufacturing environments. Full article
Show Figures

Figure 1

42 pages, 15778 KB  
Article
A Mechanistic Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach Informed by In Vitro and Clinical Studies for Topical Administration of Adapalene Gels
by Namrata S. Matharoo, Harsha T. Garimella, Thu M. Truong, Saiaditya Badeti, Joyce X. Cui, Sesha Rajeswari Talluri, Amitkumar Virani, Babar K. Rao and Bozena Michniak-Kohn
Pharmaceutics 2025, 17(9), 1108; https://doi.org/10.3390/pharmaceutics17091108 (registering DOI) - 25 Aug 2025
Abstract
Background/Objectives: Adapalene is a synthetic retinoid used as a treatment for acne vulgaris. In this study, we attempted to evaluate the dermal pharmacokinetics of adapalene utilizing experimental and in silico tools. Methods: We utilized three over the counter (OTC) adapalene gels to evaluate [...] Read more.
Background/Objectives: Adapalene is a synthetic retinoid used as a treatment for acne vulgaris. In this study, we attempted to evaluate the dermal pharmacokinetics of adapalene utilizing experimental and in silico tools. Methods: We utilized three over the counter (OTC) adapalene gels to evaluate local dermal pharmacokinetics. A data-driven, robust, mechanistic dermal physiologically based pharmacokinetic (PBPK) model was developed by integrating the physicochemical properties of adapalene, the formulation attributes of the gels, and the biophysical aspects of dermal absorption. The dermal PBPK model was validated against experimental data using in vitro release studies and in vitro permeation studies with human cadaver skin. A clinical study was performed to evaluate the effects of adapalene from the three gel formulations. The impact of adapalene delivery from three gels on the stratum corneum (SC) thickness, pilosebaceous unit area, keratinocyte number, and epidermal thickness was captured using a non-invasive technique, line-field confocal optical coherence tomography (LC–OCT). These responses were evaluated using an Emax model. Results: The dermal PBPK model has successfully predicted adapalene penetration profiles across different gel formulations. The model accuracy, in predicting drug release and permeation characteristics, was confirmed using the experimental data. Clinical evaluation revealed formulation-dependent differences in adapalene’s effects on measured skin parameters, with distinct pharmacodynamic profiles observed for each gel formulation. Conclusions: The overall study gave us a detailed insight into potential effects of formulation on the dermal pharmacokinetics and pharmacodynamics of adapalene using three marketed gels. Full article
(This article belongs to the Special Issue Development of Physiologically Based Pharmacokinetic (PBPK) Modeling)
Show Figures

Figure 1

Back to TopTop