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17 pages, 3392 KB  
Article
Investigation into the Working Behavior of Geotextile Pipe-Bag Systems on Soft Soil Foundations in the Ningde Port Industrial Zone, China
by Peijun Fan, Honglei Ren, Xiatao Zhang, Wei Li and Wanli Guo
Water 2025, 17(21), 3063; https://doi.org/10.3390/w17213063 (registering DOI) - 25 Oct 2025
Abstract
With the rapid development of coastal and nearshore engineering projects in China, geotextile pipe and bag (GPB) structures have been increasingly applied in marine land reclamation and coastal protection works. To better understand the mechanical behavior of GPB structures on soft soil foundations, [...] Read more.
With the rapid development of coastal and nearshore engineering projects in China, geotextile pipe and bag (GPB) structures have been increasingly applied in marine land reclamation and coastal protection works. To better understand the mechanical behavior of GPB structures on soft soil foundations, this study conducts a systematic investigation into the mechanical properties of both soft soils and GPBs using a physical model test system. By integrating numerical simulations, the stress–deformation characteristics of GPB structures on soft soils and the evolution of pore pressure are further analyzed. The results indicate that the compression curve of soft soil exhibits significant nonlinearity, with silt showing higher apparent compressibility than silty clay. Experimental data yielded the compression coefficient λ and rebound coefficient μ for both soil types. As consolidation pressure increases, deviatoric stress in the soft soil rises notably, demonstrating typical strain-hardening behavior. Based on these findings, the critical state effective stress ratio M was determined for both soil types. The study also establishes the development laws of cohesion c and friction angle φ during soil consolidation, as well as the variation of pore water pressure under different confining pressures. Interface tests clarify the relationships between cohesion and friction angle at the interfaces between geotextile pipe bags and sand, and between adjacent pipe bag layers. Numerical simulations reveal that the reclamation construction process significantly influences structural horizontal displacement. Significant stress concentration occurs at the toe of the slope, while the central portion of the pipe-bag structure experiences maximum tensile stress—still within the material’s allowable stress limit. The installation of drainage boards effectively accelerates pore pressure dissipation, achieving nearly complete consolidation within one year after construction. This research provides a scientific foundation and practical engineering guidance for assessing the overall stability and safety of (GPB) structures on soft soil foundations in coastal regions. Full article
(This article belongs to the Special Issue Coastal Engineering and Fluid–Structure Interactions)
16 pages, 1985 KB  
Article
Investigation on High-Temperature and High-Field Reliability of NMOS Devices Fabricated Using 28 nm Technology After Heavy-Ion Irradiation
by Yanrong Cao, Zhixian Zhang, Longtao Zhang, Miaofen Li, Shuo Su, Weiwei Zhang, Youli Xu, Dingqi Huang, Le Liu, Ling Lv and Xiaohua Ma
Micromachines 2025, 16(11), 1216; https://doi.org/10.3390/mi16111216 (registering DOI) - 25 Oct 2025
Abstract
This paper investigates the degradation of 28 nm technology NMOS devices under high-temperature and high-field conditions following heavy-ion irradiation. The effects of stress time, stress magnitude, temperature, device structural dimensions, and heavy-ion radiation fluence on device degradation were analyzed. The results indicate that [...] Read more.
This paper investigates the degradation of 28 nm technology NMOS devices under high-temperature and high-field conditions following heavy-ion irradiation. The effects of stress time, stress magnitude, temperature, device structural dimensions, and heavy-ion radiation fluence on device degradation were analyzed. The results indicate that under positive gate bias stress, the threshold voltage of NMOS devices exhibits a continuous positive shift. Increased stress time, higher stress magnitude, elevated temperature, and reduced device structural dimensions all aggravate device degradation. The combined effects of electrical stress and radiation lead to a degradation that initially decreases and then increases. This is because the trap charges generated in the gate oxide layer by radiation are positive charges at low fluence, compensating for the negative charges generated under electrical stress, thereby reducing degradation. However, at high fluence, the negative interface trap charges increase, while radiation also generates positive charges in the shallow trench isolation (STI) region. These two factors collectively contribute to increased device degradation. Full article
18 pages, 2378 KB  
Article
Spin-Coating of Sizing on Glass Fibres
by James L. Thomason, Roya Akrami and Liu Yang
Micro 2025, 5(4), 47; https://doi.org/10.3390/micro5040047 (registering DOI) - 25 Oct 2025
Abstract
Size is a surface coating applied to glass fibres during manufacture, and it is arguably the most important component in a glass-reinforced composite. Research and development on sizings and composite interfaces are severely limited, because conventional laboratory- scale glass fibre sizing analysis commonly [...] Read more.
Size is a surface coating applied to glass fibres during manufacture, and it is arguably the most important component in a glass-reinforced composite. Research and development on sizings and composite interfaces are severely limited, because conventional laboratory- scale glass fibre sizing analysis commonly involves sample preparation by dip coating, resulting in a size layer up to two orders of magnitude thicker than industrially produced glass fibre products. This makes it difficult to make useful comparisons between industrial and lab-scale-prepared samples when investigating size performance. This paper presents a novel, but simple, use of laboratory spin coating to apply a size layer to glass fibres that are similar to industrial-sized fibres. Thermogravimetric analysis and electron microscopy were used to investigate the size layers of glass fibres spin-coated with two chemically different sizing formulations, under a range of conditions. The average size layer thickness on spin-coated glass fibres could be easily and simply controlled in a range from 0.05 to 0.6 µm, compared to 0.4–1.3 µm on samples dip coated with the same size formulation and 0.06–0.10 µm on industrial reference samples. This novel application of the spin coating method offers the potential of improved research sample preparation, as it eliminates the need to alter the concentration of the sizing formulations to unacceptably low levels to obtain normal size layer thicknesses. Full article
20 pages, 3719 KB  
Communication
Research on High-Density Discrete Seismic Signal Denoising Processing Method Based on the SFOA-VMD Algorithm
by Xiaoji Wang, Kai Lin, Guangzhao Guo, Xiaotao Wen and Dan Chen
Geosciences 2025, 15(11), 409; https://doi.org/10.3390/geosciences15110409 (registering DOI) - 25 Oct 2025
Abstract
With the increasing demand for precision in seismic exploration, high-resolution surveys and shallow-layer identification have become essential. This requires higher sampling frequencies during seismic data acquisition, which shortens seismic wavelengths and enables the capture of high-frequency signals to reveal finer subsurface structural details. [...] Read more.
With the increasing demand for precision in seismic exploration, high-resolution surveys and shallow-layer identification have become essential. This requires higher sampling frequencies during seismic data acquisition, which shortens seismic wavelengths and enables the capture of high-frequency signals to reveal finer subsurface structural details. However, the insufficient sampling rate of existing petroleum instruments prevents the effective capture of such high-frequency signals. To address this limitation, we employ high-frequency geophones together with high-density and high-frequency acquisition systems to collect the required data. Meanwhile, conventional processing methods such as Fourier transform-based time–frequency analysis are prone to phase instability caused by frequency interval selection. This instability hinders the accurate representation of subsurface structures and reduces the precision of shallow-layer phase identification. To overcome these challenges, this paper proposes a denoising method for high-sampling-rate seismic data based on Variational Mode Decomposition (VMD) optimized by the Starfish Optimization Algorithm (SFOA). The denoising results of simulated signals demonstrate that the proposed method effectively preserves the stability of noise-free regions while maintaining the integrity of peak signals. It significantly improves the signal-to-noise ratio (SNR) and normalized cross-correlation coefficient (NCC) while reducing the root mean square error (RMSE) and relative root mean square error (RRMSE). After denoising the surface mountain drilling-while-drilling signals, the resulting waveforms show a strong correspondence with the low-velocity zone interfaces, enabling clear differentiation of shallow stratigraphic distributions. Full article
(This article belongs to the Section Geophysics)
8 pages, 1493 KB  
Article
Single-Crystalline Si Stacked AlGaN/GaN High-Electron-Mobility Transistors with Enhanced Two-Dimensional Electron Gas Density
by Goeun Ham, Eungyeol Shin, Sangwon Yoon, Jihoon Yang, Youngjin Choi, Gunwoo Lim and Kwangeun Kim
Micromachines 2025, 16(11), 1214; https://doi.org/10.3390/mi16111214 (registering DOI) - 25 Oct 2025
Abstract
High-electron-mobility transistors (HEMTs) are characterized by the formation of a two-dimensional electron gas (2DEG) induced by the polarization effects. Considerable studies have been conducted to improve the electrical properties of HEMTs by regulating the 2DEG density. In this study, a Si/GaN heterojunction was [...] Read more.
High-electron-mobility transistors (HEMTs) are characterized by the formation of a two-dimensional electron gas (2DEG) induced by the polarization effects. Considerable studies have been conducted to improve the electrical properties of HEMTs by regulating the 2DEG density. In this study, a Si/GaN heterojunction was fabricated through the transfer of a heavily boron-doped Si nanomembrane. The holes in the p-Si layer integrated on top of the HEMT not only increased the surface positive charge, which eventually increased the density of electrons at the AlGaN/GaN interface, but also acted as a passivation layer to improve the performance of AlGaN/GaN HEMTs. Electrical characterization revealed that the maximum drain current increased from 668 mA/mm to 740 mA/mm, and the maximum transconductance improved from 200.2 mS/mm to 220.4 mS/mm. These results were due to the surface positive charge induced by the p-Si layer, which lowered the energy band diagram and increased the electron concentration at the AlGaN/GaN interface by a factor of 1.4 from 1.52 × 1020 cm−3 to 2.11 × 1020 cm−3. Full article
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16 pages, 2782 KB  
Article
Defect–Coating–Wavelength Coupling Effects on Nano-Scale Electric Field Modulation in Fused Silica Under Multi-Wavelength Irradiation
by Hongbing Cao, Xing Peng, Feng Shi and Xinjie Zhao
Nanomaterials 2025, 15(21), 1626; https://doi.org/10.3390/nano15211626 (registering DOI) - 25 Oct 2025
Abstract
Fused silica optical components with antireflection (AR) coatings are key components in high-power laser systems. However, their reliability is severely challenged by multi-wavelength irradiation and the presence of unavoidable matrix surface defects. To investigate the coupling effects of electric field modulation between multi-wavelength [...] Read more.
Fused silica optical components with antireflection (AR) coatings are key components in high-power laser systems. However, their reliability is severely challenged by multi-wavelength irradiation and the presence of unavoidable matrix surface defects. To investigate the coupling effects of electric field modulation between multi-wavelength irradiation, AR coating layers, and defects in AR-coated fused silica, this paper uses the finite-difference time-domain (FDTD) method to simulate the nanoscale electric field intensity distribution in fused silica coated with a double-layer AR coating at three different design wavelengths using multi-wavelength lasers. The effects of electric field coupling between the coating layers and defects are analyzed for three representative scratch geometries. The results show that when the incident wavelength matches the AR design wavelength, the interface field is effectively suppressed, resulting in a smoother field distribution and localized hot spots. Conversely, mismatched wavelengths induce severe field distortion, producing multiple hot spots and lateral interference fringes. Wide, shallow scratches are particularly sensitive to wavelength mismatch, with a 532 nm AR coating exhibiting a global maximum enhancement factor of 1.63442 for 355 nm incident light. These findings highlight the coupling effects of scratch geometry, AR coating dispersion, and laser wavelength on electric field modulation. This research provides valuable insights for optimizing antireflection coatings and improving defect tolerance in multi-wavelength laser applications, helping to improve the reliability of high-power laser systems. Full article
(This article belongs to the Section Nanophotonics Materials and Devices)
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16 pages, 4606 KB  
Article
AlOOH-Coated Glass Fiber-Reinforced Composites for Pipeline Rehabilitation: Enhancement of Interfacial Adhesion and Durability
by Mengfei Du, Xilai Yan, Chuandong Wu and Ke Wang
Materials 2025, 18(21), 4887; https://doi.org/10.3390/ma18214887 (registering DOI) - 24 Oct 2025
Abstract
Glass fiber (GF) reinforced unsaturated polyester resin (UP) composites are used in cured-in-place pipe (CIPP) rehabilitation technology of drainage systems due to their low cost and excellent force chemical properties. However, the weak interfacial compatibility between GF and the polymer matrix limits the [...] Read more.
Glass fiber (GF) reinforced unsaturated polyester resin (UP) composites are used in cured-in-place pipe (CIPP) rehabilitation technology of drainage systems due to their low cost and excellent force chemical properties. However, the weak interfacial compatibility between GF and the polymer matrix limits the stress transfer efficiency. Herein, a strategy of a polyhydric boehmite (AlOOH) layer coated on GF (GF-AlOOH) was developed for improving the mechanical properties of UP composites, and the enhancement effects of the coating process were analyzed. The AlOOH-modified GFs significantly improved the flexural and tensile strengths of the modified composites by 41.21% and 21.05%, respectively. Moreover, the enhancement mechanism was explored by analyzing the surface chemical structure of GF-AlOOHs. The nano-AlOOH was grafted on the GF surface by O=Al–OH. Meanwhile, the increase in the mechanical properties of UP/GF-AlOOH was mainly attributed to the combined effect of mechanical interlocking interaction, covalent bonding and hydrogen bonding, which improved the interfacial adhesion between GF and UP. In summary, this work provides effective guidance for achieving high-quality interfaces in GF composites and offers important insights into designing durable and cost-effective materials for CIPP rehabilitation and broader infrastructure applications. Full article
(This article belongs to the Special Issue Advanced Polymers and Composites for Multifunctional Applications)
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25 pages, 1260 KB  
Review
Enhancing Emergency Response: The Critical Role of Interface Design in Mining Emergency Robots
by Roya Bakzadeh, Kiazoa M. Joao, Vasileios Androulakis, Hassan Khaniani, Sihua Shao, Mostafa Hassanalian and Pedram Roghanchi
Robotics 2025, 14(11), 148; https://doi.org/10.3390/robotics14110148 (registering DOI) - 24 Oct 2025
Abstract
While robotic technologies have shown great promise in enhancing productivity and safety, their integration into the mining sector, particularly for search and rescue (SAR) missions, remains limited. The success of these systems depends not only on their technical capabilities, but also on the [...] Read more.
While robotic technologies have shown great promise in enhancing productivity and safety, their integration into the mining sector, particularly for search and rescue (SAR) missions, remains limited. The success of these systems depends not only on their technical capabilities, but also on the effectiveness of human–robot interaction (HRI) in high-risk, time-sensitive environments. This review synthesizes key human factors, including cognitive load, situational awareness, trust, and attentional control, that critically influence the design and operation of robotic interfaces for mine rescue missions. Drawing on established cognitive theories such as Endsley’s Situational Awareness Model, Wickens’ Multiple Resource Theory, Mental Model and Cognitive Load Theory, we identified core challenges in current SAR interface design for mine rescue missions and mapped them to actionable design principles. We proposed a human-centered framework tailored to underground mine rescue operations, with specific recommendations for layered feedback, multimodal communication, and adaptive interfaces. By contextualizing cognitive science in the domain of mining emergencies, this work offers a structured guide for designing intuitive, resilient, and operator-supportive robotic systems. Full article
(This article belongs to the Section Industrial Robots and Automation)
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20 pages, 1574 KB  
Article
Analysis of Torsional Vibration of Single Pile in Orthotropic Layered Soil
by Zixin Lian, Yanzhi Zhu and Yongzhi Jiu
Buildings 2025, 15(21), 3834; https://doi.org/10.3390/buildings15213834 - 23 Oct 2025
Abstract
To address the difficulty in obtaining analytical solutions for the torsional vibration response of pile foundations in orthotropic layered soil foundations subjected to torsional excitation at the pile top, this study investigates a layered recursive algorithm based on the Hankel transform. An integral [...] Read more.
To address the difficulty in obtaining analytical solutions for the torsional vibration response of pile foundations in orthotropic layered soil foundations subjected to torsional excitation at the pile top, this study investigates a layered recursive algorithm based on the Hankel transform. An integral transformation method is employed to reduce the dimensionality of the coupled pile–soil torsional vibration equations, converting the three-dimensional system of partial differential equations into a set of ordinary differential equations. Combining the constitutive properties of transversely anisotropic strata with interlayer contact conditions, a transfer matrix model is established. Employing inverse transformation coupled with the Gauss–Kronrod integration method, an explicit frequency-domain solution for the torsional dynamic impedance at the pile top is derived. The research findings indicate that the anisotropy coefficient of the foundation significantly influences both the real and imaginary parts of the impedance magnitude. The sequence of soil layer distribution and the bonding state at interfaces jointly affect the nonlinear transmission characteristics of torque along the pile shaft. Full article
(This article belongs to the Section Building Structures)
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19 pages, 3386 KB  
Article
Wellbore Stability in Interbedded Weak Formations Utilizing a Shear-Based Method: Numerical Realization and Analysis
by Yuanhong Han, Qian Gao, Deliang Fu, Desheng Zhou, Ahmad Ghassemi, Zhiyu Zhou, Hongyong Guo and Haiyang Wang
Processes 2025, 13(11), 3389; https://doi.org/10.3390/pr13113389 - 23 Oct 2025
Viewed by 23
Abstract
This study employs a finite element approach to investigate wellbore stability in interbedded weak formations, such as unconsolidated layers, with a focus on the failure-tendency method, which is derived according to the principle of Mohr–Coulomb theory. The numerical model is successfully verified through [...] Read more.
This study employs a finite element approach to investigate wellbore stability in interbedded weak formations, such as unconsolidated layers, with a focus on the failure-tendency method, which is derived according to the principle of Mohr–Coulomb theory. The numerical model is successfully verified through analytical solutions for stress distributions around a borehole. Through finite element modeling, the method captures critical shear failure thresholds, exemplifying how variations in horizontal stress anisotropy, orientation of interbedded weak layers, and mechanical properties of layered geological formations impact wellbore stability in stratified formations. Results indicate that the potential unstable regions, aligned in the direction of minimum principal stress, and the range of unstable regions gradually enlarge as the internal cohesive strength decreases. By modeling heterogeneous rock sequences with explicit representation of interbedded weak layers and stress anisotropy, the analysis reveals that interbedded weak layers are prone to shear-driven borehole breakouts due to stress redistribution and relatively lower internal cohesive strength. As compressive stresses concentrate at interfaces between stiff and compliant layers, breakouts are induced at those weak layers along the interfaces; this type of failure is also manifested through a field borehole breakout observation. Simulation results reveal the significant influences of the mechanical properties of layered formations and in situ stress on the distribution of instability regions around a borehole. The study underscores the necessity of layer-specific geomechanical models to predict shear failure in complex layered geological formations and offers insights for optimizing drilling parameters to enhance wellbore stability in anisotropic, stratified subsurface environments. Full article
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17 pages, 2813 KB  
Article
Acoustic Emission from GaN-on-Sapphire Structures
by Bartlomiej K. Paszkiewicz, Bogdan Paszkiewicz and Andrzej Dziedzic
Electronics 2025, 14(21), 4146; https://doi.org/10.3390/electronics14214146 - 23 Oct 2025
Viewed by 40
Abstract
This paper presents a study on the propagation of acoustic waves in gallium nitride (GaN) layers deposited on sapphire substrate. The influence of GaN layer thickness and the configuration of interdigital transducers (IDTs) on the generation and propagation of different surface wave modes, [...] Read more.
This paper presents a study on the propagation of acoustic waves in gallium nitride (GaN) layers deposited on sapphire substrate. The influence of GaN layer thickness and the configuration of interdigital transducers (IDTs) on the generation and propagation of different surface wave modes, including Rayleigh, Sezawa, and Love waves, was analyzed. Experimental measurements in the 100 MHz–6 GHz range were complemented by numerical simulations using the finite element method (FEM). The results demonstrated a strong dependence of wave characteristics on technological parameters, particularly the quality of the GaN–sapphire interface. The data obtained can be utilized for optimizing the design of acoustic sensors, resonators, and RF filters. Full article
(This article belongs to the Section Electronic Materials, Devices and Applications)
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11 pages, 1116 KB  
Proceeding Paper
IoT Architecture for Inclusive Urban Mobility: A Design Science Research Approach to Sustainable Transportation in Morocco
by Tarik Abdennasser, Souad Alaoui, Imane Chlioui and Abdelhalim Hnini
Eng. Proc. 2025, 112(1), 46; https://doi.org/10.3390/engproc2025112046 - 22 Oct 2025
Viewed by 69
Abstract
We introduce an IoT architecture that addresses critical mobility challenges in Morocco’s urban transportation ecosystem. Using Design Science Research methodology, we developed a complete system integrating smart infrastructure, edge computing, and accessible interfaces to enhance service quality while prioritizing inclusivity for vulnerable populations. [...] Read more.
We introduce an IoT architecture that addresses critical mobility challenges in Morocco’s urban transportation ecosystem. Using Design Science Research methodology, we developed a complete system integrating smart infrastructure, edge computing, and accessible interfaces to enhance service quality while prioritizing inclusivity for vulnerable populations. Our five-layer architecture targets institutional capacity limitations, inadequate service levels, and accessibility barriers present in Morocco’s transportation landscape. An evaluation of our proposed solution shows how technology integration can advance eco-friendly transport goals while accommodating limited resources in developing contexts. The research contributes novel insights into IoT architectural models for inclusive design alongside practical recommendations for transportation authorities seeking to leverage digital transformation for more equitable urban mobility. Full article
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11 pages, 2027 KB  
Communication
Silicon@Carbon Composite with Bioinspired Root-Nodule Nanostructures as Anode for High-Performance Lithium-Ion Batteries
by Yitong Sun, Lei Zhao, Ning Mi, Jiahao He and Jiantie Xu
Molecules 2025, 30(21), 4157; https://doi.org/10.3390/molecules30214157 - 22 Oct 2025
Viewed by 157
Abstract
Silicon (Si) is a promising high-capacity anode material for lithium–ion batteries but faces challenges such as severe volume fluctuations during cycles and the formation of unstable solid-electrolyte interphase films on the electrode surface. To address these limitations, we developed a bioinspired Si@C composite [...] Read more.
Silicon (Si) is a promising high-capacity anode material for lithium–ion batteries but faces challenges such as severe volume fluctuations during cycles and the formation of unstable solid-electrolyte interphase films on the electrode surface. To address these limitations, we developed a bioinspired Si@C composite anode through polydopamine-mediated self-assembly of aromatic polyamide nanofibers and nano–Si, followed by controlled pyrolysis at 1000 °C under N2. The resulting hierarchical architecture mimics the symbiotic root-nodule structure of legumes, featuring vascular bundle-like carbon frameworks and chemically bonded Si/C interfaces. The optimized composite delivers an initial capacity of 1107.0 mAh g−1 at 0.1 A g−1 and retains 580.0 mAh g−1 after 100 cycles with 52.4% retention. The exceptional electrochemical properties arise from the optimized architecture and surface interactions. The nature-inspired carbon network minimizes ionic transport resistance via vertically aligned porous pathways while simultaneously boosting lithium–ion adsorption capacity. Furthermore, radially aligned graphitic ribbons are generated through controlled polyamide thermal transformation that effectively mitigates electrode swelling and maintains stable interfacial layers during cycling. Full article
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13 pages, 7189 KB  
Communication
Comparative Study on Structural and Transport Properties of SSC and LSC PFSA Ionomers in PEMFCs with Coexistence of O2 and N2: Molecular Dynamics Simulation Approach
by Guanghua Wei, Jingjing Huang, Lina Yu, Jinghao Zhou, Jiabin You, Zhu Ling, Shenrong Ye and Junliang Zhang
Membranes 2025, 15(11), 324; https://doi.org/10.3390/membranes15110324 - 22 Oct 2025
Viewed by 195
Abstract
Efficient O2 transport through the ionomer film in cathode catalyst layers (CCLs) is a critical factor for the output performance of proton exchange membrane fuel cells (PEMFCs), yet the molecular mechanisms of gas transport in ionomers remain elusive. Herein, molecular dynamics (MDs) [...] Read more.
Efficient O2 transport through the ionomer film in cathode catalyst layers (CCLs) is a critical factor for the output performance of proton exchange membrane fuel cells (PEMFCs), yet the molecular mechanisms of gas transport in ionomers remain elusive. Herein, molecular dynamics (MDs) simulations are employed to investigate short-side-chain (SSC) and long-side-chain (LSC) perfluorosulfonic acid (PFSA) ionomers on Pt/C surfaces with the coexistence of O2/N2. The results reveal that the side-chain structures significantly modulate the ionomer nanostructures and gas transport. SSC ionomers form compact hydrophobic domains and more interconnected hydrophilic–hydrophobic interfaces, thereby facilitating more efficient O2 transport pathways than LSC ionomers, particularly at low hydration (λ = 3). At high hydration (λ = 11), swelling of water domains attenuates these structural disparities and becomes the dominant factor governing gas transport. In addition, O2 diffusion consistently exceeds that of N2, while the diffusion coefficients of O2, N2 and H3O+ become larger at high hydration. Collectively, these findings demonstrate the structural advantages of SSC ionomers in facilitating coupled oxygen and proton transport, offering molecular-level insights to inform the rational design of high-performance PEMFCs. Full article
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16 pages, 1200 KB  
Review
Hsp60-Bearing Exosomes in Helicobacter pylori-Induced Gastric Tumorigenesis: A Pathomorphological and Therapeutical Overview
by Melania Ionelia Gratie, Olga Maria Manna, Salvatore Accomando, Giovanni Tomasello, Francesco Cappello and Alberto Fucarino
Cells 2025, 14(21), 1652; https://doi.org/10.3390/cells14211652 - 22 Oct 2025
Viewed by 188
Abstract
Chronic infection with Helicobacter pylori is the leading environmental cause of gastric carcinogenesis, yet the molecular pathways remain incompletely defined. This review links H. pylori-derived outer membrane vesicles (OMVs) and host epithelial exosomes through their shared cargo of heat shock protein 60 [...] Read more.
Chronic infection with Helicobacter pylori is the leading environmental cause of gastric carcinogenesis, yet the molecular pathways remain incompletely defined. This review links H. pylori-derived outer membrane vesicles (OMVs) and host epithelial exosomes through their shared cargo of heat shock protein 60 (GroEL/Hsp60). We proposed the concept of the “muco-microbiotic layer” as a fifth, functionally distinct layer of the gastric wall, where bacterial and host extracellular vesicles (EVs) interact within the mucus–microbiota interface. In this compartment, OMVs carrying bacterial GroEL and exosomes containing human Hsp60 engage in bidirectional communication that may promote chronic inflammation and epithelial transformation, with putative participation of molecular mimicry. The high structural homology between microbial and human Hsp60 enables repeated immune exposure to trigger cross-reactive responses—potentially leading to autoimmune-driven tissue damage, immune tolerance, and immune evasion in pre-neoplastic lesions. This vesicular crosstalk aligns with the evolution from non-atrophic gastritis to atrophy, from intestinal metaplasia to dysplasia, and lastly adenocarcinoma. Therapeutically, targeting EV-mediated Hsp60/GroEL signaling might offer promising strategies: EV-based biomarkers for early detection, monoclonal antibodies against extracellular Hsp60/GroEL, modulation of vesicle release, and probiotic-derived nanovesicles to restore mucosal balance. Hence, recognizing the muco-microbiotic layer and its vesicle-mediated signaling provides a new framework for understanding the infection–inflammation–cancer axis and for developing diagnostic and therapeutic approaches in H. pylori-associated gastric cancer. Full article
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