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14 pages, 3959 KB  
Article
Three-Dimensional Simulation-Based Comparison of Streamer Initiation in SF6/N2 and SF6/CO2 for Different Mixing Ratios and Pressures
by Muhammad Farasat Abbas, Guangyu Sun, Baohong Guo and Yanbin Xin
Appl. Sci. 2025, 15(19), 10331; https://doi.org/10.3390/app151910331 - 23 Sep 2025
Viewed by 91
Abstract
Being a greenhouse gas, SF6 has significant potential to cause global warming. No alternative gas has been found so far that meets the required criteria. Ongoing research has narrowed down the candidates to some relatively environmentally friendly elementary gases such as N [...] Read more.
Being a greenhouse gas, SF6 has significant potential to cause global warming. No alternative gas has been found so far that meets the required criteria. Ongoing research has narrowed down the candidates to some relatively environmentally friendly elementary gases such as N2, CO2, and their mixtures with a small percentage of SF6 (10–20%). Streamers are important and play a deterministic role in the breakdown phenomenon. The inception and growth of streamer discharge depend on the generation of free electrons. Various ionization sources, including field ionization, Auger release of electrons, photoionization, and electron detachment from negative ions, have been employed in dielectric media. In this work, field ionization is considered a free-electron generation mechanism for streamer initiation. In field ionization, neutral molecules produce free electrons when extremely high electric fields are present near the needle electrode. A 3D particle model with field ionization is then used to investigate positive streamer initiation in SF6/N2 and SF6/CO2 for different mixing ratios at 1 and 5 bar. It was observed that for both mixtures, the number and the apparent length of streamer branching decreased with increasing SF6 concentration and were minimal at 100% SF6. The number of branches and the apparent length of streamers were higher in the case of SF6/CO2 compared with SF6/N2 mixtures, indicating a higher ionization rate for the SF6/CO2 mixture. With increasing pressure, the branching and length of the streamers for both mixtures decreased significantly. Although the field-ionization model is only suitable for very high electric fields in the vicinity of the needle tip, its validity is still questionable for uniform fields and at lower pressures. Full article
(This article belongs to the Special Issue Plasma–Surface Interaction: Theory, Simulation and Application)
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19 pages, 2306 KB  
Article
Morphological and Transcriptomic Analyses Provide New Insights into Linseed (Linum usitatissimum L.) Seedling Roots Response to Nitrogen Stress
by Braulio J. Soto-Cerda, Giovanni Larama, Bourlaye Fofana and Izsavo Soto
Plants 2025, 14(18), 2920; https://doi.org/10.3390/plants14182920 - 19 Sep 2025
Viewed by 324
Abstract
Nitrogen (N) is the most important macro-nutrient for plant growth and development, which not only results in the highest cost in crop production but may also lead to environmental pollution. Hence, there is a need to develop N and use efficient genotypes, a [...] Read more.
Nitrogen (N) is the most important macro-nutrient for plant growth and development, which not only results in the highest cost in crop production but may also lead to environmental pollution. Hence, there is a need to develop N and use efficient genotypes, a prerequisite for which is a better understanding of N stress adaptation. Here, responses of two contrasting linseed accessions at the seedling stage were assessed for N stress-induced changes in twelve phenotypic traits and for gene expression profiling in the roots. The results showed that nine out of twelve phenotypic traits were affected under N stress conditions, and include total root length (TRL), root tips (RT), shoot dry weight (SDW), root dry weight (RDW), root-to-shoot ratio (R/S), plant nitrogen content (PNC), shoot nitrogen content (SNC), root nitrogen content (RNC), and nitrogen use efficiency (NUE). For example, under N stress, the TRL, RDW, SDW, PNC, SNC, and RNC showed reductions of 7.1, 7.6, 16.0, 43.7, 43.3, and 38.7%, respectively. The N-efficient (NE) genotype outperformed the N-inefficient (NI) genotype for all root and shoot traits and NUE under N stress and N normal conditions. Transcriptome analysis identified 1034 differentially expressed genes (DEGs) under the contrasting N conditions and uncovered the opposite responses of the two linseed genotypes to N starvation at the gene expression level. DEGs included 153 transcription factors distributed in 27 families, among which ERF, MYB, NAC, and WRKY were the most represented. In addition, DEGs involved in N absorption and transport, root development, amino acid transport, and antioxidant activity were found to be differentially expressed. The candidate genes identified in the current study are purported for their roles in N metabolism in other crops and might also play a pivotal role in N stress adaptation in linseed, and therefore could be useful for further detailed research on N stress response in linseed, paving the way toward developing N-efficient linseed cultivars with improved root system architecture. Full article
(This article belongs to the Special Issue Genetic Analysis of Plant Adaptation to Abiotic Stresses)
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16 pages, 7120 KB  
Article
Ultra-Long, Minor-Diameter, Untethered Growing Continuum Robot via Tip Actuation and Steering
by Pan Zhou, Zhaoyi Lin, Lang Zhou, Haili Li, Michael Basin and Jiantao Yao
Machines 2025, 13(9), 851; https://doi.org/10.3390/machines13090851 - 15 Sep 2025
Viewed by 401
Abstract
Continuum robots with outstanding compliance, dexterity, and lean bodies are successfully applied in medicine, aerospace engineering, the nuclear industry, rescue operations, construction, service, and manipulation. However, the inherent low stiffness characteristics of continuum bodies make it challenging to develop ultra-long and small-diameter continuum [...] Read more.
Continuum robots with outstanding compliance, dexterity, and lean bodies are successfully applied in medicine, aerospace engineering, the nuclear industry, rescue operations, construction, service, and manipulation. However, the inherent low stiffness characteristics of continuum bodies make it challenging to develop ultra-long and small-diameter continuum robots. To address this size–scale challenge of continuum robots, we developed an 8 m long continuum robot with a diameter of 23 mm by a tip actuation and growth mechanism. Meanwhile, we also realized the untethered design of the continuum robot, which greatly increased its usable space range, portability, and mobility. Demonstration experiments prove that the developed growing continuum robot has good flexibility and manipulability, as well as the ability to cross obstacles and search for targets. Its continuum body can transport liquids over long distances, providing water, medicine, and other rescue items for trapped individuals. The functionality of an untethered growing continuum robot (UGCR) can be expanded by installing multiple tools, such as a grasping tool at its tip to pick up objects in deep wells, pits, and other scenarios. In addition, we established a static model to predict the deformation of UGCR, and the prediction error of its tip position was within 2.6% of its length. We verified the motion performance of the continuum robot through a series of tests involving workspace, disturbance resistance, collision with obstacles, and load performance, thus proving its good anti-interference ability and collision stability. The main contribution of this work is to provide a technical reference for the development of ultra-long continuum robots based on the tip actuation and steering principle. Full article
(This article belongs to the Special Issue Advances and Challenges in Robotic Manipulation)
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16 pages, 1137 KB  
Article
Functional Traits of Native Plant Species That Inhibit the Seedling Growth of the Exotic Invader Solidago canadensis
by Ruixiang Ma, Jili Liang, Keyi Zuo, Ming Wu and Xiaoqi Ye
Plants 2025, 14(17), 2806; https://doi.org/10.3390/plants14172806 - 8 Sep 2025
Viewed by 455
Abstract
Rising biological invasions continue to threaten biodiversity conservation worldwide. To protect native ecosystems and biodiversity, improve resilience against invasions, and lower ecological management costs, it is crucial to identify native plant species that can endure the competitive pressures from invasive plants. This greenhouse [...] Read more.
Rising biological invasions continue to threaten biodiversity conservation worldwide. To protect native ecosystems and biodiversity, improve resilience against invasions, and lower ecological management costs, it is crucial to identify native plant species that can endure the competitive pressures from invasive plants. This greenhouse study examined the competition between Solidago canadensis and 32 native plant species to identify key functional traits of these native plant species that influence their competitive effects on and responses to S. canadensis. The results indicated that S. canadensis seedlings were unable to suppress the growth of most of the native species studied, while most native species could significantly suppress growth of S. canadensis, reducing its biomass by 12–92%. The suppression effects by native plants were closely related to their root functional traits. Specifically, annuals with higher root–shoot ratio, specific root lengths, stem biomass, plant height by day 10, and smaller number of root tips showed stronger inhibition of S. canadensis. On the other hand, perennials with smaller average root diameter, or greater root biomass and plant heights by day 60, were also more inhibitory towards S. canadensis. This study concluded that the competitive effect of seedlings of S. canadensis have weaker competitive impacts compared to most the studied native plants. Root traits are essential in the competition between native plants and S. canadensis, potentially aiding in the identification of native plant species with high resistance to invasion. Full article
(This article belongs to the Special Issue Plant Invasions and Their Interactions with the Environment)
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20 pages, 3767 KB  
Article
Numerical Investigation on Erosion Characteristics of Archimedes Spiral Hydrokinetic Turbine
by Ke Song, Huiting Huan, Liuchuang Wei and Yongli Wang
J. Mar. Sci. Eng. 2025, 13(9), 1707; https://doi.org/10.3390/jmse13091707 - 4 Sep 2025
Viewed by 384
Abstract
The Archimedes spiral hydrokinetic turbine (ASHT), an innovative horizontal-axis design, holds significant potential for harvesting energy from localized ocean and river currents. However, prolonged operation can result in blade erosion, which reduces efficiency and may lead to operational failures. To ensure reliability and [...] Read more.
The Archimedes spiral hydrokinetic turbine (ASHT), an innovative horizontal-axis design, holds significant potential for harvesting energy from localized ocean and river currents. However, prolonged operation can result in blade erosion, which reduces efficiency and may lead to operational failures. To ensure reliability and prevent damage, it is essential to accurately identify the locations and progression of wear caused by sand particle impacts. Using a CFD–DPM approach, this study systematically investigates the effects of sand concentration and particle size on erosion rates and distribution across nine ASHT configurations, along with the underlying physical mechanisms. The results indicate that erosion rate increases linearly with sand concentration due to higher particle impact frequency. Erosion zones expand from the blade tip edges toward mid-span regions and areas near the hub as concentration increases. Regarding particle size, the erosion rate increases rapidly and almost linearly for diameters below 0.6 mm, but this growth slows for larger particles due to a “momentum–quantity trade-off” effect. Blade angle also exerts a tiered influence on erosion, following the pattern medium angles > small angles > large angles. Medium angles enhance the synergy between normal and tangential impact components, maximizing erosion. Erosion primarily initiates at the blade tips and edges, with the most severe wear concentrated in these high-impact zones. The derived erosion patterns provide valuable guidance for predicting erosion, optimizing ASHT blade design, and developing effective anti-erosion strategies. Full article
(This article belongs to the Topic Marine Renewable Energy, 2nd Edition)
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22 pages, 4388 KB  
Article
Effects of Subsurface Drip Irrigation Depth on Growth Characteristics and Yield Quality of Apples (Malus pumila Mill.) in Northwest China
by Ming Zheng, Yan Sun, Weiyi Mu, Yungang Bai, Quanjiu Wang, Zhenlin Lu and Wantong Zhang
Plants 2025, 14(17), 2702; https://doi.org/10.3390/plants14172702 - 29 Aug 2025
Viewed by 578
Abstract
Subsurface drip irrigation can improve crop water and fertilizer use efficiency, but it can cause soil hypoxia. We report on experiments performed in Aksu Prefecture, Xinjiang (41°17′ N latitude, 80°17′ E longitude), from April 2023 to October 2024 using oxygenated drip irrigation from [...] Read more.
Subsurface drip irrigation can improve crop water and fertilizer use efficiency, but it can cause soil hypoxia. We report on experiments performed in Aksu Prefecture, Xinjiang (41°17′ N latitude, 80°17′ E longitude), from April 2023 to October 2024 using oxygenated drip irrigation from the surface to 50 cm depth in an apple (Malus pumila Mill.) orchard, to examine the effects of drip irrigation on inter-root hypoxia, tree growth, fruit quality, and yield. Compared with surface oxygenated drip irrigation (CK), irrigating at 10 and 30 cm increased soil water content in the root system, elevated gibberellin, zeatin ribosides, and indoleacetic acid contents and reduced abscisic acid contents in new shoot tips. Compared with CK, branch and leaf nitrogen, phosphorus, and potassium contents were increased with irrigation at depths of 10 and 30 cm. The leaf nitrogen (N), phosphorus (P), and potassium (K) contents were increased by 18.03%, 22.42%, and 16.63%, respectively, in the treatment with a burial depth of 30 cm. Among treatments, irrigation at 30 cm produced the highest average daily plant water potential, and irrigation at 50 cm was the lowest. Maximum leaf soil–plant analysis development (SPAD) values occurred when irrigated at 30 cm, and minimum values occurred at 50 cm. For both years, the largest range of light flux utilization occurred when irrigated at 30 cm and the lowest when irrigated at 50 cm. Significant correlations between indoleacetic acid (IAA), total gibberellin (GA), zeatin riboside (ZRs), leaf N content, leaf K content, plant water potential (PWP), net photosynthetic rate (Pn), SPAD, and apple yield were determined by partial mantel analysis. A significant correlation was found between abscisic acid (ABA), IAA, GA, leaf P and K content, and apple quality. Principal component analysis revealed a burial depth of 30 cm had the highest principal component composite score, indicating that this burial depth, and oxygenation and fertilization regime most favored apple growth, yield, and quality. Full article
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18 pages, 15633 KB  
Article
Comparative Analysis of Germination Traits and Gene Expression in Hybrid Progeny of Neo-Tetraploid Rice Under NaCl Stress Conditions
by Peishan Huang, Xinhui Xie, Xiaoyu Cai, Shihui Chen, Yutong Zheng, Zijuan Huang, Muhammad Qasim Shahid, Xiangdong Liu and Jinwen Wu
Agronomy 2025, 15(9), 2066; https://doi.org/10.3390/agronomy15092066 - 27 Aug 2025
Viewed by 488
Abstract
Neo-tetraploid rice is a highly fertile variety created from autotetraploid rice. It demonstrates stronger heterosis and produces stable hybrid progeny. However, there is insufficient data regarding abiotic stress in neo-tetraploid hybrid progeny, especially in relation to salt stress. Two hybrid progenies, high salt-resistance [...] Read more.
Neo-tetraploid rice is a highly fertile variety created from autotetraploid rice. It demonstrates stronger heterosis and produces stable hybrid progeny. However, there is insufficient data regarding abiotic stress in neo-tetraploid hybrid progeny, especially in relation to salt stress. Two hybrid progenies, high salt-resistance tetraploid rice hybrid progeny (HSRTH) and low salt-resistance tetraploid rice hybrid progeny (LSRTH), were generated by crossing the neo-tetraploid rice cultivars ‘Huaduo 3’ and ‘Huaduo 8’ with the autotetraploid rice Huanghuazhan-4x. Here, we assessed the germination characteristics and seedling growth of two neo-tetraploid hybrids at six NaCl concentrations: 0, 50, 100, 150, 200, and 250 mmol/L. HSRTH demonstrated a higher tolerance to salt stress, achieving a grain germination rate of 48.00 ± 2.63% compared to LSRTH, which reached only 5.00 ± 1.41% under a 250 mmol/L NaCl treatment. Cytological observations showed that the root tip differentiation zone and coleoptiles of HSRTH were less affected by NaCl stress treatment, resulting in fewer cortical cell abnormalities, decreased stele issues, and fewer rhizodermis cell problems, such as shrinkage. Gene expression analysis revealed nine genes that showed differential expression in HSRTH compared to LSRTH. Our study demonstrated that HSRTH showed strong salt stress tolerance, providing a basis for selecting salt-resistant rice germplasm and offering insights for developing salt-tolerant rice varieties using neo-tetraploid resources. Full article
(This article belongs to the Special Issue Innovative Research on Rice Breeding and Genetics)
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16 pages, 5195 KB  
Article
Effects of Flooding Duration on Plant Root Traits and Soil Erosion Resistance in Water-Level Fluctuation Zones: A Case Study from the Three Gorges Reservoir, China
by Zhen Ju, Ke Fang, Yuqi Wang, Bijie Hu, Yi Long, Zhonglin Shi and Ping Zhou
Water 2025, 17(17), 2531; https://doi.org/10.3390/w17172531 - 26 Aug 2025
Viewed by 725
Abstract
The water-level fluctuation zone (WLFZ) of the Three Gorges Reservoir (TGR) experiences seasonal submergence and exposure, resulting in soil structure degradation and intensified erosion. This study investigated how flooding duration affects root development and the erosion resistance of root–soil complexes in the WLFZ [...] Read more.
The water-level fluctuation zone (WLFZ) of the Three Gorges Reservoir (TGR) experiences seasonal submergence and exposure, resulting in soil structure degradation and intensified erosion. This study investigated how flooding duration affects root development and the erosion resistance of root–soil complexes in the WLFZ of the TGR. Two representative herbaceous species were chosen for this study: Xanthium sibiricum, an annual with a taproot system, and Cynodon dactylon, a perennial with a fibrous root system. Root traits, soil erodibility K-value, shear strength, and soil texture were measured from plant and soil samples collected at different flooding durations (145–175 m elevations). Our results showed that prolonged flooding significantly suppressed root growth, particularly in the 145–155 m zone, where root length density and root tips were markedly reduced (p < 0.05). Soil erodibility increased with flooding duration, with erodibility K-values ranging from 0.050 ± 0.002 to 0.062 ± 0.001 t·hm2·h/(MJ·mm·hm2), while shear strength declined correspondingly. Textural shifts from silty loam to silt were observed at zones experiencing extended flooding, contributing to aggregate instability and decreased internal friction angles. Notably, Cynodon dactylon demonstrated superior soil reinforcement capacity compared to Xanthium sibiricum, with its root volume and surface area significantly correlated with reduced K-values (p < 0.01) and enhanced shear strength (p < 0.001), enabling it to better prevent bank erosion under flooding conditions. These findings underscore the importance of root morphological traits in maintaining soil stability under hydrological stress and highlight the potential of perennial fibrous-rooted species for vegetation-based erosion control in fine-textured riparian zones. This study provides a theoretical basis and practical reference for ecological restoration in the WLFZ of the TGR and similar environments. Full article
(This article belongs to the Special Issue Agricultural Water-Land-Plant System Engineering)
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19 pages, 5379 KB  
Article
Geometric Coupling Effects of Multiple Cracks on Fracture Behavior: Insights from Discrete Element Simulations
by Shuangping Li, Bin Zhang, Hang Zheng, Zuqiang Liu, Xin Zhang, Linjie Guan and Han Tang
Intell. Infrastruct. Constr. 2025, 1(2), 6; https://doi.org/10.3390/iic1020006 - 25 Aug 2025
Viewed by 391
Abstract
Understanding the multi-crack coupling fracture behavior in brittle materials is particularly critical for aging dam infrastructure, where 78% of structural failures originate from crack network coalescence. In this study, we introduce the concepts of crack distance ratio (DR) and size ratio (SR) to [...] Read more.
Understanding the multi-crack coupling fracture behavior in brittle materials is particularly critical for aging dam infrastructure, where 78% of structural failures originate from crack network coalescence. In this study, we introduce the concepts of crack distance ratio (DR) and size ratio (SR) to describe the relationship between crack position and length and employ the discrete element method (DEM) for extensive numerical simulations. Specifically, a crack density function is introduced to assess microscale damage evolution, and the study systematically examines the macroscopic mechanical properties, failure modes, and microscale damage evolution of rock-like materials under varying DR and SR conditions. The results show that increasing the crack distance ratio and crack angle can inhibit the crack formation at the same tip of the prefabricated crack. The increase in the size ratio will promote the formation of prefabricated cracks on the same side. The increase in the distance ratio and size ratio significantly accelerate the rapid increase in crack density in the second stage. The crack angle provides the opposite effect. In the middle stage of loading, the growth rate of crack density decreases with the increase in crack angle. Overall, the size ratio has a greater influence on the evolution of microscopic damage. This research provides new insights into understanding and predicting the behavior of materials under complex stress conditions, thus contributing to the optimization of structural design and the improvement of engineering safety. Full article
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16 pages, 3539 KB  
Article
Arabidopsis Ubiquitin E3 Ligase AtCHYR1 Promotes ROS Production in Plant Responses to Sugar Availability
by Shuangcheng Ding, Yuxin Xue, Yulu Teng, Simin Qin and Hongwei Wang
Plants 2025, 14(17), 2617; https://doi.org/10.3390/plants14172617 - 22 Aug 2025
Viewed by 457
Abstract
Glucose functions as both an essential energy source and a critical signaling molecule, playing pivotal roles in regulating plant growth, development, and stress responses. Here, we report that AtCHYR1, a previously characterized RING-type ubiquitin E3 ligase involved in drought tolerance, also participates [...] Read more.
Glucose functions as both an essential energy source and a critical signaling molecule, playing pivotal roles in regulating plant growth, development, and stress responses. Here, we report that AtCHYR1, a previously characterized RING-type ubiquitin E3 ligase involved in drought tolerance, also participates in glucose signaling. Exposure to high glucose levels significantly inhibits AtCHYR1 expression, particularly in root tips, while low glucose conditions, such as osmotic stress, sugar starvation, and dark conditions, induce its expression. Importantly, analysis of chyr1 mutants and plants overexpressing AtCHYR1 revealed that AtCHYR1 positively regulated the high glucose-mediated inhibition of germination and root growth, as well as starvation-induced growth retardation, through enhanced reactive oxygen species (ROS) accumulation in root tips. Additionally, transcriptional levels of glucose-activated pathogenesis-related (PR) and defense-related genes were reduced, while hypoxia-associated and ROS-inducing genes were significantly upregulated in AtCHYR1-overexpressing plants. Collectively, our findings provide novel insights into the role of AtCHYR1 in plant responses to fluctuating sugar availability and its control of ROS homeostasis during seed germination and plant growth. Full article
(This article belongs to the Topic Plants Nutrients, 2nd Volume)
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28 pages, 11764 KB  
Article
Study on Cavitation Flow Structure Evolution in the Hump Region of Water-Jet Pumps Under the Valley Condition
by Yingying Zheng, Yun Long, Min Liu, Hanqiao Han, Kai Wang, Jinqing Zhong and Yun Long
J. Mar. Sci. Eng. 2025, 13(8), 1598; https://doi.org/10.3390/jmse13081598 - 21 Aug 2025
Viewed by 361
Abstract
During the hydraulic performance experiment, significant vibration and noise were observed in the mixed-flow pump operating in the hump region. Cavitation occurrence in the impeller flow channels was confirmed through the transparent chamber. To analyze cavitation flow structure evolution in the mixed-flow pump, [...] Read more.
During the hydraulic performance experiment, significant vibration and noise were observed in the mixed-flow pump operating in the hump region. Cavitation occurrence in the impeller flow channels was confirmed through the transparent chamber. To analyze cavitation flow structure evolution in the mixed-flow pump, this paper integrates numerical and experimental approaches, capturing cavitation flow structures under the valley condition through high-speed photography technology. During the various stages of cavitation development, the cavitation forms are mostly vortex cavitation, cloud cavitation, and perpendicular vortex cavitation. Impeller rotation induces downstream transport of shedding cloud cavitation shedding structures. Flow blockage occurs when cavitation vortexes obstruct specific passages, accelerating cavitation growth that culminates in head reduction through energy dissipation mechanisms. Vortex evolution analysis revealed enhanced density of small-scale vortex structures with stronger localized core intensity in the impeller and diffuser. Despite larger individual vortex scales, reduced core intensity persists throughout the full flow domain. Concurrently, velocity profile characteristics across flow rates and blade sections (spanwise from tip to root) indicate heightened predisposition to flow separation, recirculation zones, and low-velocity regions during off-design operation. This study provides scientific guidance for enhancing anti-cavitation performance in the hump region. Full article
(This article belongs to the Section Ocean Engineering)
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12 pages, 5636 KB  
Article
CTOD Evaluation of High-Nitrogen Steels for Low-Temperature Welded Structures
by Min-Suk Oh, Young-Gon Kim and Sung-Min Joo
Metals 2025, 15(8), 916; https://doi.org/10.3390/met15080916 - 19 Aug 2025
Viewed by 555
Abstract
Welded structures, such as offshore platforms, require robust toughness in their heat-affected zones (HAZ) to withstand low-temperature environments. The coarse-grained HAZ (CGHAZ) adjacent to the fusion boundary often exhibits reduced toughness due to grain coarsening, particularly under high heat input welding conditions aimed [...] Read more.
Welded structures, such as offshore platforms, require robust toughness in their heat-affected zones (HAZ) to withstand low-temperature environments. The coarse-grained HAZ (CGHAZ) adjacent to the fusion boundary often exhibits reduced toughness due to grain coarsening, particularly under high heat input welding conditions aimed at enhancing productivity. To address this, high-nitrogen steels containing TiN particles were developed to suppress austenite grain growth by leveraging the thermal stability of TiN precipitates. Three high-nitrogen steels with varying carbon contents (0.09%, 0.11%, and 0.15%) were fabricated and subjected to crack tip opening displacement (CTOD) testing at −20 °C and −40 °C to evaluate low-temperature HAZ toughness. Results indicate that high-nitrogen TiN steels exhibit superior CTOD values (1.38–2.73 mm) compared to conventional 490-MPa class steels, with no significant reduction in toughness despite increased carbon content. This is attributed to the presence of stable TiN particles, which restrict austenite grain growth during welding thermal cycles, and the formation of fine ferrite–pearlite microstructures in the HAZ. These findings highlight the efficacy of high-nitrogen TiN steels in enhancing low-temperature fracture resistance for welded structures. Full article
(This article belongs to the Special Issue Advances in Welding Processes of Metallic Materials)
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34 pages, 3045 KB  
Review
Living on the Edge: ROS Homeostasis in Cancer Cells and Its Potential as a Therapeutic Target
by Noah Brandl, Rebecca Seitz, Noah Sendtner, Martina Müller and Karsten Gülow
Antioxidants 2025, 14(8), 1002; https://doi.org/10.3390/antiox14081002 - 16 Aug 2025
Viewed by 1661
Abstract
Reactive oxygen species (ROS) act as double-edged swords in cancer biology—facilitating tumor growth, survival, and metastasis at moderate levels while inducing oxidative damage and cell death when exceeding cellular buffering capacity. To survive under chronic oxidative stress, cancer cells rely on robust antioxidant [...] Read more.
Reactive oxygen species (ROS) act as double-edged swords in cancer biology—facilitating tumor growth, survival, and metastasis at moderate levels while inducing oxidative damage and cell death when exceeding cellular buffering capacity. To survive under chronic oxidative stress, cancer cells rely on robust antioxidant systems such as the glutathione (GSH) and thioredoxin (Trx), and superoxide dismutases (SODs). These systems maintain redox homeostasis and sustain ROS-sensitive signaling pathways including MAPK/ERK, PI3K/Akt/mTOR, NF-κB, STAT3, and HIF-1α. Targeting the antioxidant defense mechanisms of cancer cells has emerged as a promising therapeutic strategy. Inhibiting the glutathione system induces ferroptosis, a non-apoptotic form of cell death driven by lipid peroxidation, with compounds like withaferin A and altretamine showing strong preclinical activity. Disruption of the Trx system by agents such as PX-12 and dimethyl fumarate (DMF) impairs redox-sensitive survival signaling. Trx reductase inhibition by auranofin or mitomycin C further destabilizes redox balance, promoting mitochondrial dysfunction and apoptosis. SOD1 inhibitors, including ATN-224 and disulfiram, selectively enhance oxidative stress in tumor cells and are currently being tested in clinical trials. Mounting preclinical and clinical evidence supports redox modulation as a cancer-selective vulnerability. Pharmacologically tipping the redox balance beyond the threshold of cellular tolerance offers a rational and potentially powerful approach to eliminate malignant cells while sparing healthy tissue, highlighting novel strategies for targeted cancer therapy at the interface of redox biology and oncology. Full article
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19 pages, 478 KB  
Article
When Does Air Transport Infrastructure and Trade Flows Matter? Threshold Effects on Economic Growth in ASEAN Countries
by Warunya Chaitarin, Paravee Maneejuk, Songsak Sriboonchitta and Woraphon Yamaka
Sustainability 2025, 17(16), 7406; https://doi.org/10.3390/su17167406 - 15 Aug 2025
Viewed by 699
Abstract
This study examines how air transport infrastructure and trade flows influence economic growth across ASEAN countries, with a focus on identifying the threshold levels at which these factors begin to enhance growth. Despite increasing investment in regional logistics and connectivity, policymakers often lack [...] Read more.
This study examines how air transport infrastructure and trade flows influence economic growth across ASEAN countries, with a focus on identifying the threshold levels at which these factors begin to enhance growth. Despite increasing investment in regional logistics and connectivity, policymakers often lack evidence-based thresholds to guide infrastructure and trade policy for long-term development. Addressing this gap, this study applies a Dynamic Panel Threshold Model to uncover the tipping points at which improvements in air cargo volume (lnCargo) and air transport infrastructure quality (lnQAir) translate into stronger economic growth. By employing System-GMM and First-Difference GMM estimations, the analysis captures the threshold effects of air cargo volume (lnCargo) and air transport infrastructure quality (lnQAir) on economic growth over varying regimes. The results reveal significant single-threshold effects for both lnCargo and lnQAir, indicating that their contributions to economic growth become substantial after surpassing specific critical levels. When air cargo volume exceeds approximately 267,067 tons per year (lnCargo > 5.5875), its positive effect on economic growth strengthens, particularly when accompanied by high-quality infrastructure. Similarly, air transport infrastructure quality exhibits a significantly stronger impact on economic growth once it exceeds the critical threshold of lnQAir = 1.5476 (≈4.7001 index points). These findings emphasize the complementarity between trade flows and infrastructure, aligning with endogenous growth theory, which suggests that infrastructure investments yield increasing returns when integrated with trade expansion. Policy implications suggest that ASEAN economies should adopt demand-driven infrastructure development aligned with trade dynamics, prioritizing regional connectivity, logistics efficiency, and investment attraction to sustain long-term economic growth. Full article
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20 pages, 2116 KB  
Article
Effects of Different Soil Phosphorus Levels on the Physiological and Growth Characteristics of Phyllostachys edulis (Moso Bamboo) Seedlings
by Zhenya Yang and Benzhi Zhou
Plants 2025, 14(16), 2473; https://doi.org/10.3390/plants14162473 - 9 Aug 2025
Viewed by 494
Abstract
Soil phosphorus (P) availability is a critical factor affecting the productivity of Phyllostachys edulis (moso bamboo) forests. However, the mechanisms underlying the physiological and growth responses of moso bamboo to varying soil P conditions remain poorly understood. The aim of this study was [...] Read more.
Soil phosphorus (P) availability is a critical factor affecting the productivity of Phyllostachys edulis (moso bamboo) forests. However, the mechanisms underlying the physiological and growth responses of moso bamboo to varying soil P conditions remain poorly understood. The aim of this study was to elucidate the adaptive mechanisms of moso bamboo to different soil P levels from the perspectives of root morphological and architectural plasticity, as well as the allocation strategies of nutrient elements and photosynthates. One-year-old potted seedlings of moso bamboo were subjected to four P addition treatments (P1: 0, P2: 25 mg·kg−1, P3: 50 mg·kg−1, P4: 100 mg·kg−1) for one year. The biomass of different seedling organs, root morphological and architectural indices, and the contents of nitrogen (N), P, and non-structural carbohydrates in the roots, stems, and leaves were measured in July and December. P addition increased the root length (by 113.8%), root surface area (by 146.5%), root average diameter (by 14.8%), root length ratio of thicker roots (diameter > 0.9 mm), number of root tips (by 31.9%), fractal dimension (by 5.6%), P accumulation (by 235.8%), and contents of starch (ST) and soluble sugars (SS), while it decreased the specific root length (by 31.7%), root branching angle (by 1.9%), root topological index (by 4.8%), root length ratio of finer roots (diameter ≤ 0.3 mm), SS/ST, and N/P. The root–shoot ratio showed a downward trend in July and an upward trend in December. Our results indicated that moso bamboo seedlings tended to form roots with a small diameter, high absorption efficiency, and minimal internal competition to adapt to soil P deficiency and carbon limitation caused by low P. Under low-P conditions, moso bamboo prioritized allocating photosynthates and P to roots, promoting the conversion of starch to soluble sugars to support root morphological and architectural plasticity and maintain root growth and physiological functions. Sole P addition eliminated the constraints of low P on moso bamboo growth and nutrient accumulation but caused imbalances in the N/P. Full article
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