Recent Advances in Biocatalysis and Enzyme Engineering

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 695

Special Issue Editors

Beijing Key Laboratory of Bioprocess, National Energy R&D Center for Biorefinery, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
Interests: enzymes; biocatalysis; enzyme engineering; directed evolution; rational design; metabolic engineering
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Guest Editor
Beijing Key Laboratory of Bioprocess, National Energy R&D Center for Biorefinery, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
Interests: biocatalysis; enzyme engineering; metabolic engineering

Special Issue Information

Dear Colleagues,

Biocatalysis refers to the utilization of enzymes, or whole cells, to catalyze a single- or multi-step chemical reaction, converting synthetic molecules or natural metabolites into value-added products. However, the industrial applications of biocatalysis are modest, perhaps in part because of the limitations of biocatalysts, such as limited enzyme availability, substrate scope, and operational stability. In recent decades, with the progress of new enzyme discovery, the engineering and evolution of proteins, machine learning for biocatalyst and route design, and metabolic pathway optimization, the limitations of biocatalysis have been greatly improved. With the rapid development of enzyme engineering and metabolic engineering, biocatalysis has been firmly established as a tool for synthesizing valuable products and performing chemically challenging reactions.

This Special Issue focuses on recent advances in biocatalysis and enzyme engineering, including enzyme design and evolution, metabolic pathway optimization, and biosynthetic route discovery. Methodological and theoretical approaches to biocatalysis design and the development of high-throughput screening methods for biocatalysis are also welcome.

If you would like to submit papers to this Special Issue or have any questions, please contact the in-house editor, Ms. Rita Lin ([email protected]).

Dr. Kaili Nie
Dr. Junfeng Liu
Guest Editors

Manuscript Submission Information

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Keywords

  • enzyme
  • biocatalysis
  • enzyme discovery
  • enzyme engineering
  • enzyme evolution
  • multienzymatic synthesis
  • metabolic engineering
  • metabolic pathway

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Published Papers (1 paper)

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Research

14 pages, 6507 KiB  
Article
Enhanced Catalytic Synthesis of Flavonoid by UV-B Radiation in Artemisia argyi
by Haike Gu, Shuang Liu, Guoyu Li, Li Hou, Tengyuan Shen, Meifang Song and Junfeng Liu
Catalysts 2024, 14(8), 504; https://doi.org/10.3390/catal14080504 - 5 Aug 2024
Viewed by 489
Abstract
Enzymatic synthesis of specific active substances is an important foundation for biological adaptations to various stresses. In this study, we investigated the metabolic response of the medicinal herb Artemisia argyi to UV-B radiation through transcriptome and metabolome analysis. In all tested samples, there [...] Read more.
Enzymatic synthesis of specific active substances is an important foundation for biological adaptations to various stresses. In this study, we investigated the metabolic response of the medicinal herb Artemisia argyi to UV-B radiation through transcriptome and metabolome analysis. In all tested samples, there were 544 shared differentially expressed genes, most of which were linked to the metabolism of flavonoids and fatty acids. A total of 283 differential metabolites were identified and classified into 10 categories, with flavonoids being the largest category. Through an integrated analysis of genes and metabolites involved in flavonoid biosynthesis, flavonoids were predicted to be critical for the adaptation of A. argyi to UV radiation. The increased plant hormones methyl jasmonate and salicylic acid were considered as key regulatory approaches for catalyzing the large-scale synthesis of flavonoids. We explored this by investigating the flavonoid production of A. argyi grown at different altitudes. It showed that total flavonoid content of A. argyi planted in high-altitude areas was 45% higher than that in low-altitude areas. These findings not only deepen our understanding of flavonoid anabolism and its regulation but also provide a reliable strategy for improving flavonoid content in the genus Artemisia. Full article
(This article belongs to the Special Issue Recent Advances in Biocatalysis and Enzyme Engineering)
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