Exploring the Cytotoxic and Antioxidant Potential of Plant Extracts

Topic Information

Dear Colleagues,

It is a great honor for us to serve as Topic Editors for the Topic “Exploring the Cytotoxic and Antioxidant Potential of Plant Extracts”. In recent years, pharmacological research has directed its attention to studying the potential biological activities of plant extracts, given the increasing utilization of plants for treating several ailments worldwide and since they are generally considered as safer and possessing minor side effects compared to synthetic drugs. In particular, there is now an outstanding number of studies on the cytotoxic and antioxidant effects of plant extracts. We seek to further underline the importance of these studies by publishing new research or review articles on this Topic. There are no limitations on the type of plant, extracts, or assays used, but phytochemical analyses must fully explain the positive or negative results of the plant extracts from a phytochemical standpoint. We look forward to receiving your papers.

Dr. Claudio Frezza
Dr. Manuela Cipoletti
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Molecules molecules	4.6	8.6	1996	16.1 Days	CHF 2700	Submit
Plants plants	4.1	7.6	2012	17.7 Days	CHF 2700	Submit
Toxins toxins	4.0	8.2	2009	18.4 Days	CHF 2700	Submit
Antioxidants antioxidants	6.6	12.4	2012	17.4 Days	CHF 2900	Submit

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Published Papers (1 paper)

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All Molecules Plants Toxins Antioxidants

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28 pages, 1659 KB  

Open AccessReview

The Potential Therapeutic Applications of Natural Products in the Oxidative Stress-Related MVA Pathway: Focus on HMGCR

by Yu-Ning Teng

Antioxidants 2025, 14(8), 1001; https://doi.org/10.3390/antiox14081001 - 16 Aug 2025

Viewed by 459

Abstract

This review explores the therapeutic promise of natural compounds in modulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in cholesterol synthesis. HMGCR dysregulation is implicated in dyslipidemia, cardiovascular disease, and cancer, conditions linked to oxidative stress. While statins inhibit HMGCR, their side effects [...] Read more.

This review explores the therapeutic promise of natural compounds in modulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in cholesterol synthesis. HMGCR dysregulation is implicated in dyslipidemia, cardiovascular disease, and cancer, conditions linked to oxidative stress. While statins inhibit HMGCR, their side effects necessitate exploring alternatives. The review highlights various natural compounds—flavonoids, phenolic acids, stilbenes, and herbal formulations—with HMGCR-modulating and antioxidant capabilities. In vitro and in vivo studies suggest these compounds offer a promising avenue for treating HMGCR-related conditions. Synergistic effects are observed when combining natural products with statins, hinting at combination therapies that could lower statin dosages and reduce adverse effects. Natural HMGCR modulators hold therapeutic promise but face hurdles like limited in vivo data, regulatory issues, variability in composition, potential drug interactions, and safety concerns. Future research must prioritize comprehensive mechanistic studies, standardized preparations, and well-designed clinical trials. Overcoming these challenges through rigorous science is essential for integrating natural HMGCR modulators into clinical practice and improving patient outcomes in a safe and effective manner. Specifically, clinical trials should consider combination therapies and comparison with standard treatments like statins. More research is also needed on optimal dosages and treatment regimens. Full article

(This article belongs to the Topic Exploring the Cytotoxic and Antioxidant Potential of Plant Extracts)

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