Molecular Mechanism, Diagnosis and Treatment of Retinal and Optic Nerve Diseases

Topic Information

Dear Colleagues,

Multiple disease processes can affect the retina and/or the optic nerve. Retinal diseases like diabetic retinophathy or age-related macular degeneration (AMD) are the leading causes of blindness worldwide. But also common optic nerve diseases, including glaucoma, optic neuritis, and ischemic optic neuropathy can lead to visual impairment. These diseases represent a major socioeconomic burden and impair patients’ quality of life. Due to an aging society, more and more people will be affected in the next years. Despite the prevalence of these diseases, the precise pathogenesic processes involved are still unknown and warrant further research. Complex disease models (cell or organ cultures as well as animal models), are needed in order to better understand these pathologies and enable the development of novel or modified treatment options for these diseases to prevent blidness. This Research Topic aims to summarize current knowledge of pathologies of retinal and optic nerve diseases. It further focuses on discovery of novel treatment options.

Prof. Dr. Stephanie C. Joachim
Dr. Bettina Hohberger
Dr. Julie Sanderson
Prof. Dr. Jan Darius Unterlauft
Dr. Lauren K. Wareham
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Current Issues in Molecular Biology cimb	2.8	2.9	1999	15.8 Days	CHF 2200
International Journal of Molecular Sciences ijms	4.9	8.1	2000	16.8 Days	CHF 2900
International Journal of Translational Medicine ijtm	-	-	2021	24.2 Days	CHF 1000
Scientia Pharmaceutica scipharm	2.3	4.6	1930	26.1 Days	CHF 1000

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All CIMB IJMS IJTM Sci. Pharm.

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14 pages, 1277 KiB  

Open AccessArticle

A Pilot Study of a Panel of Ocular Inflammation Biomarkers in Patients with Primary Sjögren’s Syndrome

by Ana Boto de los Bueis, Miguel de la Fuente, Rafael Montejano-Milner, Almudena del Hierro Zarzuelo, Elena Vecino and Arantxa Acera

Curr. Issues Mol. Biol. 2023, 45(4), 2881-2894; https://doi.org/10.3390/cimb45040188 - 1 Apr 2023

Cited by 3 | Viewed by 2254

Abstract

Ocular diseases have a strong impact on individuals, the effects of which extend from milder visual impairment to blindness. Due to this and to their prevalence, these conditions constitute important health, social and economic challenges. Thus, improvements in their early detection and diagnosis [...] Read more.

Ocular diseases have a strong impact on individuals, the effects of which extend from milder visual impairment to blindness. Due to this and to their prevalence, these conditions constitute important health, social and economic challenges. Thus, improvements in their early detection and diagnosis will help dampen the impact of these conditions, both on patients and on healthcare systems alike. In this sense, identifying tear biomarkers could establish better non-invasive approaches to diagnose these diseases and to monitor responses to therapy. With this in mind, we developed a solid phase capture assay, based on antibody microarrays, to quantify S100A6, MMP-9 and CST4 in human tear samples, and we used these arrays to study tear samples from healthy controls and patients with Sjögren’s Syndrome, at times concomitant with rheumatoid arthritis. Our results point out that the detection of S100A6 in tear samples seems to be positively correlated to rheumatoid arthritis, consistent with the systemic nature of this autoinflammatory pathology. Thus, we provide evidence that antibody microarrays may potentially help diagnose certain pathologies, possibly paving the way for significant improvements in the future care of these patients. Full article

(This article belongs to the Topic Molecular Mechanism, Diagnosis and Treatment of Retinal and Optic Nerve Diseases)

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