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Molecular Mechanism, Diagnosis and Treatment of Retinal and Optic Nerve...
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Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, 44892 Bochum, Germany
Dr. Bettina Hohberger
Department of Ophthalmology, University Hospital Erlangen, 90766 Erlangen, Germany
Dr. Julie Sanderson
School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK
Department of Ophthalmology, Inselspital, University of Bern, Freiburgstrasse 15, 3010 Bern, Switzerland
Department of Ophthalmology & Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, USA
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Molecular Mechanism, Diagnosis and Treatment of Retinal and Optic Nerve Diseases

Abstract submission deadline
closed (31 August 2023)
Manuscript submission deadline
closed (31 October 2023)
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Topic Information

Dear Colleagues,

Multiple disease processes can affect the retina and/or the optic nerve. Retinal diseases like diabetic retinophathy or age-related macular degeneration (AMD) are the leading causes of blindness worldwide. But also common optic nerve diseases, including glaucoma, optic neuritis, and ischemic optic neuropathy can lead to visual impairment. These diseases represent a major socioeconomic burden and impair patients’ quality of life. Due to an aging society, more and more people will be affected in the next years. Despite the prevalence of these diseases, the precise pathogenesic processes involved are still unknown and warrant further research. Complex disease models (cell or organ cultures as well as animal models), are needed in order to better understand these pathologies and enable the development of novel or modified treatment options for these diseases to prevent blidness. This Research Topic aims to summarize current knowledge of pathologies of retinal and optic nerve diseases. It further focuses on discovery of novel treatment options.

Prof. Dr. Stephanie C. Joachim
Dr. Bettina Hohberger
Dr. Julie Sanderson
Prof. Dr. Jan Darius Unterlauft
Dr. Lauren K. Wareham
Topic Editors

Keywords

  • age-related macular degneration
  • diabetic retinopathy
  • glaucoma
  • multiple sclerosis
  • optic nerve
  • optic neuritis
  • optic nerve degeneration/regeneration
  • retina
  • retinitis

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Current Issues in Molecular Biology
cimb 		2.8 2.9 1999 16.8 Days CHF 2200
International Journal of Molecular Sciences
ijms 		4.9 8.1 2000 18.1 Days CHF 2900
International Journal of Translational Medicine
ijtm 		- - 2021 24 Days CHF 1000
Scientia Pharmaceutica
scipharm 		2.3 4.6 1930 31.4 Days CHF 1000

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Published Papers (1 paper)

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Article
A Pilot Study of a Panel of Ocular Inflammation Biomarkers in Patients with Primary Sjögren’s Syndrome
by Ana Boto de los Bueis, Miguel de la Fuente, Rafael Montejano-Milner, Almudena del Hierro Zarzuelo, Elena Vecino and Arantxa Acera
Curr. Issues Mol. Biol. 2023, 45(4), 2881-2894; https://doi.org/10.3390/cimb45040188 - 1 Apr 2023
Cited by 3 | Viewed by 2016
Abstract
Ocular diseases have a strong impact on individuals, the effects of which extend from milder visual impairment to blindness. Due to this and to their prevalence, these conditions constitute important health, social and economic challenges. Thus, improvements in their early detection and diagnosis [...] Read more.
Ocular diseases have a strong impact on individuals, the effects of which extend from milder visual impairment to blindness. Due to this and to their prevalence, these conditions constitute important health, social and economic challenges. Thus, improvements in their early detection and diagnosis will help dampen the impact of these conditions, both on patients and on healthcare systems alike. In this sense, identifying tear biomarkers could establish better non-invasive approaches to diagnose these diseases and to monitor responses to therapy. With this in mind, we developed a solid phase capture assay, based on antibody microarrays, to quantify S100A6, MMP-9 and CST4 in human tear samples, and we used these arrays to study tear samples from healthy controls and patients with Sjögren’s Syndrome, at times concomitant with rheumatoid arthritis. Our results point out that the detection of S100A6 in tear samples seems to be positively correlated to rheumatoid arthritis, consistent with the systemic nature of this autoinflammatory pathology. Thus, we provide evidence that antibody microarrays may potentially help diagnose certain pathologies, possibly paving the way for significant improvements in the future care of these patients. Full article
(This article belongs to the Topic Molecular Mechanism, Diagnosis and Treatment of Retinal and Optic Nerve Diseases)
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