Anthraquinones with Antiplasmodial Activity from the Roots of Rennellia elliptica Korth. (Rubiaceae)
Abstract
:1. Introduction
2. Results and Discussion
Position | Compound 1 | Compound 2 | ||||
---|---|---|---|---|---|---|
δH | δC | HMBC | δH | δC | HMBC | |
1 | - | 159.1 | - | - | 154.0 | - |
2 | - | 149.6 | - | - | 152.7 | - |
3 | 7.28, 1H, d, J = 8.7 Hz | 115.9 | C-2, C14 | 7.19, 1H, d, J = 8.4 Hz | 115.6 | C-2, C-14 |
4 | 8.17, 1H, d, J = 8.7 Hz | 125.2 | C-3, C-10,C-13, C-14 | 7.89, 1H, d, J = 8.4 Hz | 121.0 | C-3, C-10, C-13, C-14 |
5 | 8.06, 1H, s | 126.9 | C-7, C-10, C-11 | 8.12, 1H, s | 127.8 | 6-CH3, C-10, C-11 |
6 | - | 144.6 | - | - | 146.2 | - |
7 | 7.58, 1H, dd, Jo = 7.8 Hz, Jm = 1.7 Hz | 134.7 | 6-CH3, C-8, C-12 | 7.61, 1H, d, J = 8.1 Hz | 134.6 | C-6,C-8 |
8 | 8.17, 1H, d, J = 7.8 Hz | 127.0 | C-6, C-9 | 8.23, 1H, d, J = 8.1 Hz | 127.1 | C-7, C-9, C-12 |
9 | - | 182.7 | - | - | 189.1 | - |
10 | - | 182.7 | - | - | 181.8 | - |
11 | - | 132.9 | - | - | 134.0 | - |
12 | - | 132.9 | - | - | 131.1 | - |
13 | - | 127.4 | - | - | 116.1 | - |
14 | - | 127.5 | - | - | 125.5 | - |
1-OH | - | - | - | 13.20,1H,s | - | |
1-OCH3 | 4.02, 3H, s | 61.3 | C-1 | - | - | - |
2-OCH3 | 4.02, 3H, s | 56.3 | C-1,C-2,C-3 | 4.04, 3H, s | 56.4 | C-1,C-3 |
6-CH3 | 2.53, 3H, s | 21.8 | C-5, C-6, C-7 | 2.56, 3H, s | 22.0 | C-5, C-6, C-7 |
Sample | IC50 (µM) |
---|---|
1 | 1.10 |
2 | na† |
3 | 72.46 |
4 | 0.63 |
5 | 51.28 |
6 | 2.10 |
7 | 0.34 |
8 | na† |
9 | nt‡ |
10 | na† |
11 | nt‡ |
Chloroquine diphosphate | 6.30* |
3. Experimental
3.1. Instrumentation
3.2. Chemicals and Reagents
3.3. Plant Material
3.4. Extraction and Isolation of Anthraquinones
3.5. Determination of Antiplasmodial Activity
4. Conclusions
Acknowledgements
References and Notes
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Osman, C.P.; Ismail, N.H.; Ahmad, R.; Ahmat, N.; Awang, K.; Jaafar, F.M. Anthraquinones with Antiplasmodial Activity from the Roots of Rennellia elliptica Korth. (Rubiaceae). Molecules 2010, 15, 7218-7226. https://doi.org/10.3390/molecules15107218
Osman CP, Ismail NH, Ahmad R, Ahmat N, Awang K, Jaafar FM. Anthraquinones with Antiplasmodial Activity from the Roots of Rennellia elliptica Korth. (Rubiaceae). Molecules. 2010; 15(10):7218-7226. https://doi.org/10.3390/molecules15107218
Chicago/Turabian StyleOsman, Che Puteh, Nor Hadiani Ismail, Rohaya Ahmad, Norizan Ahmat, Khalijah Awang, and Faridahanim Mohd Jaafar. 2010. "Anthraquinones with Antiplasmodial Activity from the Roots of Rennellia elliptica Korth. (Rubiaceae)" Molecules 15, no. 10: 7218-7226. https://doi.org/10.3390/molecules15107218